Current SPP1782 projects

Project PI Collaborators Institute
Cellular junctions as force anchors during epithelial shape transitions Dr. Anne-Kathrin Classen Ramya Balaji, Vanessa Weichselberger Biozentrum Martinsried
Mechanotransduction and signalling by the desmosome/keratin complex Prof. Dr. Thomas M. Magin Dr. Fanny Büchau, Katrin Rietscher Institute of Biology, Leipzig
Molecular Force Measurements in Epithelial Junctions Prof. Dr. Carsten Grashoff Dr. Anna-Lena Cost, Lukas Windgaße Max Planck Institute of Biochemistry, Martinsried
Mechano-sensing mechanisms in the desmosome from molecular simulations Prof. Dr. Frauke Gräter Dr. Csaba Daday, Dr. Fan Jin Heidelberg Institute for Theoretical Studies, Heidelberg
Interplay between mechanical tension and cytoskeletal organization in cell separation at compartment boundaries in Drosophila Prof. Dr. Christian Dahmann Jing Wang Institute of Genetics, Dresden
Molecular mechanisms patterning viscosity of the junctional network during Drosophila pupal wing morphogenesis Prof. Dr. Suzanne Eaton (†) Dr. Natalie Dye, Franz Gruber Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
Coupling intercellular adhesion and cell polarity signaling at epidermal junctions Prof. Dr. Sandra Iden Martim Gomes, Michael Saynisch CECAD, Köln
Coordinated dynamics of epithelial cells in the amnioserosa of Drosophila embryos Prof. Dr. Jörg Großhans, Prof. Dr. Fred Wolf Prachi Richa, Ankit Choudhury, Matthias Häring Philipps-Universität, Marburg / MPI für Dynamik und Selbstorganisation, Göttingen
Characterization of plakophilins as desmosomal signalling hubs controlling intercellular adhesion and proliferation in the epidermis Prof. Dr. Mechthild Hatzfeld Dr. Rene Keil, Lisa Müller Institute of Molecular Medicine, Halle
Tension Generation in Epithelial Cells – the Impact of Next Neighbors Prof. Dr. Andreas Janshoff Mark Skamrahl, Tanmaya Sethi Institute of Physical Chemistry, Göttingen
Role of the tight junction-associated protein Amotl2a in regulating the Hippo pathway and the size of the posterior lateral line primordium in zebrafish Prof. Dr. Virginie Lecaudey Constanze Heinzen, Alicia Lardennois Institut für Zellbiologie und Neurowissenschaft, Frankfurt
Mechanotransduction and cytoskeletal organization by cadherins in stratifying epithelia Prof. Dr. Carien Niessen Dr. Alexander Kyumurkov, Placido Pereira, Dr. Matthias Rübsam, Aishwarya Bhosale CECAD, Köln
Desmosome-cytoskeleton dynamics Prof. Dr. Rudolf Leube Dr. Marcin Moch MOCA, Aachen
Role of Dsg2-dependent adhesion and signalling in Crohn’s disease Prof. Dr. Nicolas Schlegel, Prof. Dr. Jens Waschke Hanna Ungewiss, Jessica Neubauer Universitätsklinikum Würzburg / Institute of Anatomy and Cell Biology, München
Probing tensed cell-cell adhesions Prof. Dr. Rudolf Merkel / Dr. Bernd Hoffmann Dave Ahrens, Lena Ramms, Robin Püllen Institute of Complex Systems, Jülich
New functions of Pals1 as a signaling hub at cell-cell contacts Prof. Dr. Michael Krahn / Prof. Dr. Thomas Weide Ann-Christin Groh, Simona Lüttgenau Universitätsklinikum Münster
Piezo mechanosensitive receptor interplay with tight junction proteins for maintenance of epithelial cell number and integrity Dr. Rocío López Posadas, Ph.D. Phuong Ngo Anh Universitätsklinikum Erlangen
Deciphering the role of mechanics for epithelia trans-differentiation Dr. Alba Diz-Muñoz Leanne Strauß European Molecular Biology Laboratory (EMBL), Heidelberg
Reconstructed cell-cell interfaces with spatially defined mechanical and molecular components: biomimetic microenvironments to elucidate how extracellular mechanochemical signals are sensed and transmitted at the intercellular junctions Prof. Dr. Aránzazu del Campo Bécares Ana Díaz Álvarez, Dr. Mitchell Han Leibniz-Institut für Neue Materialien (INM), Saarbrücken
LASP1 as a functional linker protein between cadherin and actin dynamics at epithelial adherens junctions Prof. Dr. Hans-Joachim Schnittler Nadine Klusmeier Universitätsklinikum Münster
Connecting intercellular cell junctions with Hippo/YAP pathway activity in hepatocytes and liver tumor cells Dr. Kai Breuhahn Lena Thiess Universitätsklinikum Heidelberg
Functional analysis of the LIM domain protein Smallish in regulation of actomyosin contractility and junctional dynamics at the ZA Prof. Dr. Andreas Wodarz Patrizia Kroll, Dr. Irina Peek Institut I für Anatomie, Köln

Members

Name Position Project Institute
Balaji,Ramya SPP funded collaborator Cellular junctions as force anchors during epithelial shape transitions Biozentrum Martinsried
Classen,Dr. Anne-Kathrin PI Cellular junctions as force anchors during epithelial shape transitions Biozentrum Martinsried
Büchau,Dr. Fanny SPP funded collaborator Mechanotransduction and signalling by the desmosome/keratin complex Institute of Biology, Leipzig
Magin,Prof. Dr. Thomas M. PI Mechanotransduction and signalling by the desmosome/keratin complex Institute of Biology, Leipzig
Rietscher,Katrin SPP associated collaborator Mechanotransduction and signalling by the desmosome/keratin complex Institute of Biology, Leipzig
Windgaße,Lukas SPP funded collaborator Molecular Force Measurements in Epithelial Junctions Max Planck Institute of Biochemistry, Martinsried
Cost,Dr. Anna-Lena SPP funded collaborator Molecular Force Measurements in Epithelial Junctions Max Planck Institute of Biochemistry, Martinsried
Grashoff,Prof. Dr. Carsten PI Molecular Force Measurements in Epithelial Junctions Max Planck Institute of Biochemistry, Martinsried
Fan Jin SPP funded collaborator Mechano-sensing mechanisms in the desmosome from molecular simulations Heidelberg Institute for Theoretical Studies, Heidelberg
Daday,Dr. Csaba SPP funded collaborator Mechano-sensing mechanisms in the desmosome from molecular simulations Heidelberg Institute for Theoretical Studies, Heidelberg
Gräter,Prof. Dr. Frauke PI Mechano-sensing mechanisms in the desmosome from molecular simulations Heidelberg Institute for Theoretical Studies, Heidelberg
Wang,Jing SPP funded collaborator Interplay between mechanical tension and cytoskeletal organization in cell separation at compartment boundaries in Drosophila Institute of Genetics, Dresden
Dahmann,Prof. Dr. Christian PI Interplay between mechanical tension and cytoskeletal organization in cell separation at compartment boundaries in Drosophila Institute of Genetics, Dresden
Dye,Dr. Natalie SPP funded collaborator Molecular mechanisms patterning viscosity of the junctional network during Drosophila pupal wing morphogenesis Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
Eaton,Prof. Dr. Suzanne (†) PI Molecular mechanisms patterning viscosity of the junctional network during Drosophila pupal wing morphogenesis Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
Gruber,Franz SPP funded collaborator Molecular mechanisms patterning viscosity of the junctional network during Drosophila pupal wing morphogenesis Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
Gomes,Martim SPP funded collaborator Coupling intercellular adhesion and cell polarity signaling at epidermal junctions CECAD, Köln
Iden,Prof. Dr. Sandra PI Coupling intercellular adhesion and cell polarity signaling at epidermal junctions CECAD, Köln
Saynisch,Michael SPP associated collaborator Coupling intercellular adhesion and cell polarity signaling at epidermal junctions CECAD, Köln
Großhans,Prof. Dr. Jörg PI Coordinated dynamics of epithelial cells in the amnioserosa of Drosophila embryos Philipps-Universität, Marburg
Choudhury, Ankit SPP funded collaborator Coordinated dynamics of epithelial cells in the amnioserosa of Drosophila embryos Philipps-Universität, Marburg
Richa,Prachi SPP funded collaborator Coordinated dynamics of epithelial cells in the amnioserosa of Drosophila embryos Universität, Göttingen
Häring, Matthias SPP funded collaborator Coordinated dynamics of epithelial cells in the amnioserosa of Drosophila embryos Max-Planck-Institut für Dynamik und Selbstorganisation, Göttingen
Wolf,Prof. Dr. Fred PI Coordinated dynamics of epithelial cells in the amnioserosa of Drosophila embryos Max-Planck-Institut für Dynamik und Selbstorganisation, Göttingen
Hatzfeld,Prof. Dr. Mechthild PI Characterization of plakophilins as desmosomal signalling hubs controlling intercellular adhesion and proliferation in the epidermis Institute of Molecular Medicine, Halle
Keil,Dr. Rene SPP associated collaborator Characterization of plakophilins as desmosomal signalling hubs controlling intercellular adhesion and proliferation in the epidermis Institute of Molecular Medicine, Halle
Müller,Lisa SPP funded collaborator Characterization of plakophilins as desmosomal signalling hubs controlling intercellular adhesion and proliferation in the epidermis Institute of Molecular Medicine, Halle
Janshoff,Prof. Dr. Andreas PI Tension Generation in Epithelial Cells – the Impact of Next Neighbors Institute of Physical Chemistry, Göttingen
Karsch,Susanne SPP funded collaborator Tension Generation in Epithelial Cells – the Impact of Next Neighbors Institute of Physical Chemistry, Göttingen
Sethi,Tanmaya SPP funded collaborator Tension Generation in Epithelial Cells – the Impact of Next Neighbors Institute of Physical Chemistry, Göttingen
Skamrahl,Mark SPP funded collaborator Tension Generation in Epithelial Cells – the Impact of Next Neighbors Institute of Physical Chemistry, Göttingen
Kleinhans,David SPP funded collaborator Role of the tight junction-associated protein Amotl2a in regulating the Hippo pathway and the size of the posterior lateral line primordium in zebrafish Institut für Zellbiologie und Neurowissenschaft, Frankfurt
Lecaudey,Prof. Dr. Virginie PI Role of the tight junction-associated protein Amotl2a in regulating the Hippo pathway and the size of the posterior lateral line primordium in zebrafish Institut für Zellbiologie und Neurowissenschaft, Frankfurt
Molenda,Christine SPP funded collaborator Role of the tight junction-associated protein Amotl2a in regulating the Hippo pathway and the size of the posterior lateral line primordium in zebrafish Institut für Zellbiologie und Neurowissenschaft, Frankfurt
Kyumurkov,Dr. Alexander SPP associated collaborator Mechanotransduction and cytoskeletal organization by cadherins in stratifying epithelia CECAD, Köln
Niessen,Prof. Dr. Carien PI Mechanotransduction and cytoskeletal organization by cadherins in stratifying epithelia CECAD, Köln
Pereira,Placido SPP funded collaborator Mechanotransduction and cytoskeletal organization by cadherins in stratifying epithelia CECAD, Köln
Rübsam,Dr. Matthias SPP associated collaborator Mechanotransduction and cytoskeletal organization by cadherins in stratifying epithelia CECAD, Köln
Leube,Prof. Dr. Rudolf PI Desmosome-cytoskeleton dynamics MOCA, Aachen
Moch,Dr. Marcin SPP funded collaborator Desmosome-cytoskeleton dynamics MOCA, Aachen
Schlegel,Prof. Dr. Nicolas PI Role of Dsg2-dependent adhesion and signalling in Crohn’s disease Klinik und Poliklinik für Allgemein-, Viszeral-, Gefähß-, und Kinderchirurgie, Würzburg
Ungewiss,Hanna SPP funded collaborator Role of Dsg2-dependent adhesion and signalling in Crohn’s disease Institute of Anatomy and Cell Biology, München
Neubauer,Jessica SPP funded collaborator Role of Dsg2-dependent adhesion and signalling in Crohn’s disease Institute of Anatomy and Cell Biology, München
Waschke,Prof. Dr. Jens PI Role of Dsg2-dependent adhesion and signalling in Crohn’s disease Institute of Anatomy and Cell Biology, München
Ahrens,Dave SPP funded collaborator Probing tensed cell-cell adhesions Institute of Complex Systems, Jülich
Merkel,Prof. Dr. Rudolf PI Probing tensed cell-cell adhesions Institute of Complex Systems, Jülich
Hoffmann,Dr. Bernd PI Probing tensed cell-cell adhesions Institute of Complex Systems, Jülich
Pfüllen, Robin SPP funded collaborator Probing tensed cell-cell adhesions Institute of Complex Systems, Jülich
Ramms,Lena SPP funded collaborator Probing tensed cell-cell adhesions Institute of Complex Systems, Jülich
Krahn,Prof. Dr. Michael PI New functions of Pals1 as a signaling hub at cell-cell contacts Universitätsklinikum Münster
Weide, Prof. Dr. Thomas PI New functions of Pals1 as a signaling hub at cell-cell contacts Universitätsklinikum Münster
Groh,Ann-Christin SPP funded collaborator New functions of Pals1 as a signaling hub at cell-cell contacts Universitätsklinikum Münster
Lüttgenau,Simona SPP funded collaborator New functions of Pals1 as a signaling hub at cell-cell contacts Universitätsklinikum Münster
Ngo Anh, Phuong SPP funded collaborator Piezo mechanosensitive receptor interplay with tight junction proteins for maintenance of epithelial cell number and integrity Universitätsklinikum Erlangen
López Posadas,Ph.D. Dr. Rocío PI Piezo mechanosensitive receptor interplay with tight junction proteins for maintenance of epithelial cell number and integrity Universitätsklinikum Erlangen
Thiess, Lena SPP funded collaborator Connecting intercellular cell junctions with Hippo/YAP pathway activity in hepatocytes and liver tumor cells Universitätsklinikum Heidelberg
Breuhahn,Dr. Kai PI Connecting intercellular cell junctions with Hippo/YAP pathway activity in hepatocytes and liver tumor cells Universitätsklinikum Heidelberg
Klusmeier,Nadine SPP funded collaborator LASP1 as a functional linker protein between cadherin and actin dynamics at epithelial adherens junctions Universitätsklinikum Münster
Schnittler,Prof. Dr. Hans-Joachim PI LASP1 as a functional linker protein between cadherin and actin dynamics at epithelial adherens junctions Universitätsklinikum Münster
Strauß, Leanne SPP funded collaborator Deciphering the role of mechanics for epithelia trans-differentiation European Molecular Biology Laboratory (EMBL), Heidelberg
Diz-Muñoz,Dr. Alba PI Deciphering the role of mechanics for epithelia trans-differentiation European Molecular Biology Laboratory (EMBL), Heidelberg
Han,Dr. Mitchell SPP funded collaborator Reconstructed cell-cell interfaces with spatially defined mechanical and molecular components: biomimetic microenvironments to elucidate how extracellular mechanochemical signals are sensed and transmitted at the intercellular junctions Leibniz-Institut für Neue Materialien (INM), Saarbrücken
Diaz,Ana SPP funded collaborator Reconstructed cell-cell interfaces with spatially defined mechanical and molecular components: biomimetic microenvironments to elucidate how extracellular mechanochemical signals are sensed and transmitted at the intercellular junctions Leibniz-Institut für Neue Materialien (INM), Saarbrücken
del Campo Bécares,Prof. Dr. Aránzazu PI Reconstructed cell-cell interfaces with spatially defined mechanical and molecular components: biomimetic microenvironments to elucidate how extracellular mechanochemical signals are sensed and transmitted at the intercellular junctions Leibniz-Institut für Neue Materialien (INM), Saarbrücken
Kroll,Patrizia SPP funded collaborator Functional analysis of the LIM domain protein Smallish in regulation of actomyosin contractility and junctional dynamics at the ZA Institut I für Anatomie, Köln
Peek,Irina SPP funded collaborator Functional analysis of the LIM domain protein Smallish in regulation of actomyosin contractility and junctional dynamics at the ZA Institut I für Anatomie, Köln
Wodarz,Prof. Dr. Andreas PI Functional analysis of the LIM domain protein Smallish in regulation of actomyosin contractility and junctional dynamics at the ZA Institut I für Anatomie, Köln

Completed SPP1782 projects [first funding period]

Project PI Collaborators Institute
Mechanobiological Analysis of Microtubule-Based Forces at Epithelial Adherens Junctions During Tissue Morphogenesis Dr. Maja Matis Amrita Singh Institute of Cell Biology, Münster
Consequences of desmosomal alterations in the intestinal epithelia PD Dr. Pavel Strnad Prof. Dr. Peter Boor, Dr. Sonja Djudjaj, Annika Gros Department of Internal Medicine III, Aachen Institute of Pathology, Aachen
Role of JAM family adhesion molecules in epithelial cell extrusion Prof. Dr. Klaus Ebnet Christian Hartmann Institute of Medical Biochemistry, Münster
SPP 1782 Grill/Knust Prof. Dr. Stephan Grill / Prof. Dr. Elisabeth Knust Dr. David Flores-Benitez Biotec, Dresden, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
SPP 1782 Grosse Prof. Dr. Robert Grosse Dr. Katharina Grikscheit, Hanna Grobe Institute of Pharmacology, Universität Marburg
SPP 1782 Spindler Associate Prof. Dr. med. Volker Spindler   Institute of Anatomy and Cell Biology, München