Complete list of publications (2016-2022) – SPP 1782
AG Breuhahn
1: Kittas A, Delobelle A, Schmitt S, Breuhahn K, Guziolowski C, Grabe N.
Directed random walks and constraint programming reveal active pathways in hepatocyte growth factor signaling.
FEBS J. 2016 Jan;283(2):350-60. doi: 10.1111/febs.13580. Epub 2015 Nov 26. PMID: 26518250.
2: Samarin J, Laketa V, Malz M, Roessler S, Stein I, Horwitz E, Singer S, Dimou E, Cigliano A, Bissinger M, Falk CS, Chen X, Dooley S, Pikarsky E, Calvisi DF,
Schultz C, Schirmacher P, Breuhahn K.
PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells.
Hepatology. 2016 Mar;63(3):813-26. doi: 10.1002/hep.28357. Epub 2016 Jan 14. PMID: 26901106; PMCID: PMC5262441.
3: Winkler J, Roessler S, Sticht C, DiGuilio AL, Drucker E, Holzer K, Eiteneuer E, Herpel E, Breuhahn K, Gretz N, Schirmacher P, Ori A, Singer S.
Cellular apoptosis susceptibility (CAS) is linked to integrin β1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC).
Oncotarget. 2016 Apr 19;7(16):22883-92. doi: 10.18632/oncotarget.8256. PMID: 27015362; PMCID: PMC5008409.
4: Holzer K, Drucker E, Roessler S, Dauch D, Heinzmann F, Waldburger N, Eiteneuer EM, Herpel E, Breuhahn K, Zender L, Schirmacher P, Ori A, Singer S.
Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer.
Am J Pathol. 2017 Feb;187(2):228-235. doi: 10.1016/j.ajpath.2016.09.022. Epub 2016 Dec 7. PMID: 27939741.
5: Stichel D, Middleton AM, Müller BF, Depner S, Klingmüller U, Breuhahn K, Matthäus F.
An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors.
NPJ Syst Biol Appl. 2017 Mar 3;3:5. doi: 10.1038/s41540-017-0006-3. PMID: 28649432; PMCID: PMC5460121.
6: Weiler SME, Pinna F, Wolf T, Lutz T, Geldiyev A, Sticht C, Knaub M, Thomann S, Bissinger M, Wan S, Rössler S, Becker D, Gretz N, Lang H, Bergmann F,
Ustiyan V, Kalin TV, Singer S, Lee JS, Marquardt JU, Schirmacher P, Kalinichenko VV, Breuhahn K.
Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer.
Gastroenterology. 2017 Jun;152(8):2037-2051.e22. doi: 10.1053/j.gastro.2017.02.018. Epub 2017 Feb 27. PMID: 28249813.
7: Pinna F, Bissinger M, Beuke K, Huber N, Longerich T, Kummer U, Schirmacher P, Sahle S, Breuhahn K.
A20/TNFAIP3 Discriminates Tumor Necrosis Factor (TNF)-Induced NF-κB from JNK Pathway Activation in Hepatocytes.
Front Physiol. 2017 Aug 23;8:610. doi: 10.3389/fphys.2017.00610. PMID: 28878689; PMCID: PMC5572400.
8: Wan S, Meyer AS, Weiler SME, Rupp C, Tóth M, Sticht C, Singer S, Thomann S, Roessler S, Schorpp-Kistner M, Schmitt J, Gretz N, Angel P,
Tschaharganeh DF, Marquardt J, Schirmacher P, Pinna F, Breuhahn K.
Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness. Hepatology.
2018 May;67(5):1842-1856. doi: 10.1002/hep.29669. Epub 2018 Apr 1. PMID: 29152770.
9: Waly AA, El-Ekiaby N, Assal RA, Abdelrahman MM, Hosny KA, El Tayebi HM, Esmat G, Breuhahn K, Abdelaziz AI.
Methylation in MIRLET7A3 Gene Induces the Expression of IGF-II and Its mRNA Binding Proteins IGF2BP-2 and 3 in Hepatocellular Carcinoma.
Front Physiol. 2019 Jan 24;9:1918. doi: 10.3389/fphys.2018.01918. PMID: 30733684; PMCID: PMC6353855.
10: Holzer K, Ori A, Cooke A, Dauch D, Drucker E, Riemenschneider P, Andres-Pons A, DiGuilio AL, Mackmull MT, Baßler J, Roessler S, Breuhahn K, Zender
L, Glavy JS, Dombrowski F, Hurt E, Schirmacher P, Beck M, Singer S.
Nucleoporin Nup155 is part of the p53 network in liver cancer.
Nat Commun. 2019 May 14;10(1):2147. doi: 10.1038/s41467-019-10133-z. PMID: 31089132; PMCID: PMC6517424.
11: Longerich T, Endris V, Neumann O, Rempel E, Kirchner M, Abadi Z, Uhrig S, Kriegsmann M, Weiss KH, Breuhahn K, Mehrabi A, Weber TF, Wilkens L,
Straub BK, Rosenwald A, Schulze F, Brors B, Froehling S, Pellegrino R, Budczies J, Schirmacher P, Stenzinger A.
RSPO2 gene rearrangement: a powerful driver of β-catenin activation in liver tumours. Gut.
2019 Jul;68(7):1287-1296. doi: 10.1136/gutjnl-2018-317632. Epub 2019 Feb 2. PMID: 30901310.
12: Wei T, Weiler SME, Tóth M, Sticht C, Lutz T, Thomann S, De La Torre C, Straub B, Merker S, Ruppert T, Marquardt J, Singer S, Gretz N, Schirmacher P,
Breuhahn K.
YAP-dependent induction of UHMK1 supports nuclear enrichment of the oncogene MYBL2 and proliferation in liver cancer cells.
Oncogene. 2019 Jul;38(27):5541-5550. doi: 10.1038/s41388-019-0801-y. Epub 2019 Apr 1. PMID: 30936457.
13: Drucker E, Holzer K, Pusch S, Winkler J, Calvisi DF, Eiteneuer E, Herpel E, Goeppert B, Roessler S, Ori A, Schirmacher P, Breuhahn K, Singer S.
Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer. Cell Commun Signal.
2019 Nov 29;17(1):159. doi: 10.1186/s12964-019-0456-x. PMID: 31783876; PMCID: PMC6883611.
14: Weiler SME, Lutz T, Bissinger M, Sticht C, Knaub M, Gretz N, Schirmacher P, Breuhahn K.
TAZ target gene ITGAV regulates invasion and feeds back positively on YAP and TAZ in liver cancer cells.
Cancer Lett. 2020 Mar 31;473:164-175. doi: 10.1016/j.canlet.2019.12.044. Epub 2020 Jan 3. PMID: 31904487.
15: Marquard S, Thomann S, Weiler SME, Bissinger M, Lutz T, Sticht C, Tóth M, de la Torre C, Gretz N, Straub BK, Marquardt J, Schirmacher P, Breuhahn K.
Yes- associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in
hepatocarcinogenesis.
Cell Commun Signal. 2020 Oct 23;18(1):166. doi: 10.1186/s12964-020-00634-6. PMID: 33097058; PMCID: PMC7583285.
16: Thomann S, Weiler SME, Marquard S, Rose F, Ball CR, Tóth M, Wei T, Sticht C, Fritzsche S, Roessler S, De La Torre C, Ryschich E, Ermakova O, Mogler C,
Kazdal D, Gretz N, Glimm H, Rempel E, Schirmacher P, Breuhahn K.
YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis.
Cancer Res. 2020 Dec 15;80(24):5502-5514. doi: 10.1158/0008-5472.CAN-20-0242. Epub 2020 Oct 21. PMID: 33087321.
17: Tóth M, Wehling L, Thiess L, Rose F, Schmitt J, Weiler SME, Sticht C, De La Torre C, Rausch M, Albrecht T, Grabe N, Duwe L, Andersen JB, Köhler BC,
Springfeld C, Mehrabi A, Kulu Y, Schirmacher P, Roessler S, Goeppert B, Breuhahn K.
Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma.
BMC Cancer. 2021 Oct 6;21(1):1079. doi: 10.1186/s12885-021-08794-5. PMID: 34615513; PMCID: PMC8496054.
18: Thomann S, Weiler SME, Wei T, Sticht C, De La Torre C, Tóth M, Rose F, Tang Y, Ritz T, Ball C, Glimm H, Ryschich E, Schirmacher P, Breuhahn K.
YAP-induced Ccl2 expression is associated with a switch in hepatic macrophage identity and vascular remodelling in liver cancer.
Liver Int. 2021 Dec;41(12):3011-3023. doi: 10.1111/liv.15048. Epub 2021 Sep 27. PMID: 34459091.
19: Castven D, Czauderna C, Becker D, Pereira S, Schmitt J, Weinmann A, Shah V, Hajduk J, Keggenhoff F, Binder H, Keck T, Heilmann-Heimbach S, Wörns
MA, Thorgeirsson SS, Breuhahn K, Galle PR, Marquardt JU.
Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes- Associated Protein 1 Activation and Transient Expansion
of Stem-Like Cancer Cells.
Hepatol Commun. 2022 May;6(5):1140-1156. doi: 10.1002/hep4.1869. Epub 2021 Nov 24. PMID: 34817932; PMCID: PMC9035566.
20: Pellegrino R, Castoldi M, Ticconi F, Skawran B, Budczies J, Rose F, Schwab C, Breuhahn K, Neumann UP, Gaisa NT, Loosen SH, Luedde T, Costa IG,
Longerich T.
LINC00152 Drives a Competing Endogenous RNA Network in Human Hepatocellular Carcinoma. Cells.
2022 May 3;11(9):1528. doi: 10.3390/cells11091528. PMID: 35563834; PMCID: PMC9103153.
21: Revia S, Seretny A, Wendler L, Banito A, Eckert C, Breuer K, Mayakonda A, Lutsik P, Evert M, Ribback S, Gallage S, Chikh Bakri I, Breuhahn K,
Schirmacher P, Heinrich S, Gaida MM, Heikenwälder M, Calvisi DF, Plass C, Lowe SW, Tschaharganeh DF.
Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer.
Gut. 2022 Aug;71(8):1613-1628. doi:10.1136/gutjnl-2021-325405. Epub 2021 Sep 11. PMID: 34509979; PMCID: PMC9279849.
22: Gerber TS, Ridder DA, Schindeldecker M, Weinmann A, Duret D, Breuhahn K, Galle PR, Schirmacher P, Roth W, Lang H, Straub BK.
Constitutive Occurrence of E:N-cadherin Heterodimers in Adherens Junctions of Hepatocytes and Derived Tumors.
Cells. 2022 Aug 12;11(16):2507. doi: 10.3390/cells11162507. PMID: 36010583; PMCID: PMC9406782.
23: Wehling L, Keegan L, Fernández-Palanca P, Hassan R, Ghallab A, Schmitt J, Tang Y, Le Marois M, Roessler S, Schirmacher P, Kummer U, Hengstler JG,
Sahle S, Breuhahn K.
Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury.
Elife. 2022 Oct 18;11:e78540. doi: 10.7554/eLife.78540. PMID: 36255405; PMCID: PMC9578710.
AG Classen
1: Bielmeier C, Alt S, Weichselberger V, La Fortezza M, Harz H, Jülicher F, Salbreux G, Classen AK.
Interface Contractility between Differently Fated Cells Drives Cell Elimination and Cyst Formation.
Curr Biol. 2016 Mar 7;26(5):563-74. doi: 10.1016/j.cub.2015.12.063. Epub 2016 Feb 4. PMID: 26853359; PMCID: PMC5282066.
2: La Fortezza M, Schenk M, Cosolo A, Kolybaba A, Grass I, Classen AK.
JAK/STAT signalling mediates cell survival in response to tissue stress.
Development. 2016 Aug 15;143(16):2907-19. doi: 10.1242/dev.132340. Epub 2016 Jul 6. PMID: 27385008.
3: Balaji R, Bielmeier C, Harz H, Bates J, Stadler C, Hildebrand A, Classen AK.
Calcium spikes, waves and oscillations in a large, patterned epithelial tissue.
Sci Rep. 2017 Feb 20;7:42786. doi: 10.1038/srep42786. PMID: 28218282; PMCID: PMC5317010.
4: Schunter S, Villa R, Flynn V, Heidelberger JB, Classen AK, Beli P, Becker PB.
Ubiquitylation of the acetyltransferase MOF in Drosophila melanogaster.
PLoS One. 2017 May 16;12(5):e0177408. doi: 10.1371/journal.pone.0177408. PMID: 28510597; PMCID: PMC5433716.
5: La Fortezza M, Grigolon G, Cosolo A, Pindyurin A, Breimann L, Blum H, van Steensel B, Classen AK.
DamID profiling of dynamic Polycomb-binding sites in Drosophila imaginal disc development and tumorigenesis.
Epigenetics Chromatin. 2018 Jun 5;11(1):27. doi: 10.1186/s13072-018-0196-y. Erratum in: Epigenetics Chromatin. 2018 Jul 3;11(1):38.
PMID: 29871666; PMCID: PMC5987561.
6: La Fortezza M, Grigolon G, Cosolo A, Pindyurin A, Breimann L, Blum H, van Steensel B, Classen AK.
Correction to: DamID profiling of dynamic Polycomb- binding sites in Drosophila imaginal disc development and tumorigenesis.
Epigenetics Chromatin. 2018 Jul 3;11(1):38. doi: 10.1186/s13072-018-0206-0. Erratum for: Epigenetics Chromatin. 2018 Jun 5;11(1):27.
PMID: 29970137; PMCID: PMC6029416.
7: Cosolo A, Jaiswal J, Csordás G, Grass I, Uhlirova M, Classen AK.
JNK- dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress.
Elife. 2019 Feb 8;8:e41036. doi: 10.7554/eLife.41036. PMID: 30735120; PMCID: PMC6389326.
8: Balaji R, Weichselberger V, Classen AK.
Response of Drosophila epithelial cell and tissue shape to external forces in vivo. Development.
2019 Sep 6;146(17):dev171256. doi: 10.1242/dev.171256. PMID: 31399470.
9: Dahmann C, Classen AK.
Charting the unknown currents of cellular flows and forces.
Development. 2020 Dec 21;147(24):dev186403. doi: 10.1242/dev.186403. PMID: 33355242.
10: Weichselberger V, Dondl P, Classen AK.
Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis.
Nat Commun. 2022 Oct 26;13(1):6377. doi: 10.1038/s41467-022-33845-1. PMID: 36289235; PMCID: PMC9605976.
11: Crucianelli C, Jaiswal J, Vijayakumar Maya A, Nogay L, Cosolo A, Grass I, Classen AK.
Distinct signaling signatures drive compensatory proliferation via S-phase acceleration.
PLoS Genet. 2022 Dec 15;18(12):e1010516. doi: 10.1371/journal.pgen.1010516. PMID: 36520882; PMCID: PMC9799308.
AG Dahmann
1: Michel M, Dahmann C.
Memorizing Shape to Orient Cell Division.
Dev Cell. 2016 Mar 21;36(6):589-90. doi: 10.1016/j.devcel.2016.03.005. PMID: 27003930.
2: Aurich F, Dahmann C.
A Mutation in fat2 Uncouples Tissue Elongation from Global Tissue Rotation.
Cell Rep. 2016 Mar 22;14(11):2503-10. doi: 10.1016/j.celrep.2016.02.044. Epub 2016 Mar 10. PMID: 26972006.
3: Michel M, Aliee M, Rudolf K, Bialas L, Jülicher F, Dahmann C.
The Selector Gene apterous and Notch Are Required to Locally Increase Mechanical Cell Bond Tension at the Drosophila Dorsoventral Compartment
Boundary.
PLoS One. 2016 Aug 23;11(8):e0161668. doi: 10.1371/journal.pone.0161668. PMID: 27552097; PMCID: PMC4995041.
4: Michel M, Dahmann C.
Regulating mechanical tension at compartment boundaries in Drosophila.
Fly (Austin). 2016 Oct;10(4):204-9. doi: 10.1080/19336934.2016.1207028. Epub 2016 Jun 30. PMID: 27362651; PMCID: PMC5036931.
5: Dahmann C.
MoD Special Issue on the roles of physical forces in animal development.
Mech Dev. 2017 Apr;144(Pt A):1. doi: 10.1016/j.mod.2017.02.002. PMID: 28332982.
6: Michel M, Dahmann C.
Tissue mechanical properties modulate cell extrusion in the Drosophila abdominal epidermis.
Development. 2020 Mar 11;147(5):dev179606. doi: 10.1242/dev.179606. PMID: 32161061.
7: Sui L, Dahmann C.
Wingless counteracts epithelial folding by increasing mechanical tension at basal cell edges in Drosophila.
Development. 2020 Mar 11;147(5):dev184713. doi: 10.1242/dev.184713. PMID: 32161062.
8: Wang J, Dahmann C.
Establishing compartment boundaries in Drosophila wing imaginal discs: An interplay between selector genes, signaling pathways and cell
mechanics.
Semin Cell Dev Biol. 2020 Nov;107:161-169. doi: 10.1016/j.semcdb.2020.07.008. Epub 2020 Jul 27. PMID: 32732129.
9: Sui L, Dahmann C.
Increased lateral tension is sufficient for epithelial folding in Drosophila.
Development. 2020 Dec 4;147(23):dev194316. doi: 10.1242/dev.194316. PMID: 33277300.
10: Dahmann C, Classen AK.
Charting the unknown currents of cellular flows and forces.
Development. 2020 Dec 21;147(24):dev186403. doi: 10.1242/dev.186403. PMID: 33355242.
11: Töpfer U, Guerra Santillán KY, Fischer-Friedrich E, Dahmann C.
Distinct contributions of ECM proteins to basement membrane mechanical properties in Drosophila.
Development. 2022 May 15;149(10):dev200456. doi: 10.1242/dev.200456. Epub 2022 May 16. PMID: 35575071.
AG Del Campo
1: Xu J, Cui J, Del Campo A, Shin CH.
Four and a Half LIM Domains 1b (Fhl1b) Is Essential for Regulating the Liver versus Pancreas Fate Decision and for β-Cell Regeneration.
PLoS Genet. 2016 Feb 4;12(2):e1005831. doi: 10.1371/journal.pgen.1005831. PMID: 26845333; PMCID: PMC4741517.
2: Farrukh A, Paez JI, Salierno M, del Campo A.
Bioconjugating Thiols to Poly(acrylamide) Gels for Cell Culture Using Methylsulfonyl Co-monomers.
Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2092-6. doi: 10.1002/anie.201509986. Epub 2016 Jan 6. PMID: 26836343.
3: Salierno MJ, García-Fernandez L, Carabelos N, Kiefer K, García AJ, del Campo A.
Phototriggered fibril-like environments arbitrate cell escapes and migration from endothelial monolayers.
Biomaterials. 2016 Mar;82:113-23. doi: 10.1016/j.biomaterials.2015.12.001. Epub 2015 Dec 17. PMID: 26757258.
4: Xue L, Pham JT, Iturri J, Del Campo A.
Stick-Slip Friction of PDMS Surfaces for Bioinspired Adhesives.
Langmuir. 2016 Mar 15;32(10):2428-35. doi: 10.1021/acs.langmuir.6b00513. Epub 2016 Mar 3. PMID: 26903477.
5: Pham JT, Xue L, Del Campo A, Salierno M.
Guiding cell migration with microscale stiffness patterns and undulated surfaces.
Acta Biomater. 2016 Jul 1;38:106-15. doi: 10.1016/j.actbio.2016.04.031. Epub 2016 Apr 19. PMID: 27109767.
6: Neubauer JW, Xue L, Erath J, Drotlef DM, Campo AD, Fery A.
Monitoring the Contact Stress Distribution of Gecko-Inspired Adhesives Using Mechano-Sensitive Surface Coatings.
ACS Appl Mater Interfaces. 2016 Jul 20;8(28):17870-7. doi: 10.1021/acsami.6b05327. Epub 2016 Jul 7. PMID: 27327111.
7: Iacomino M, Paez JI, Avolio R, Carpentieri A, Panzella L, Falco G, Pizzo E, Errico ME, Napolitano A, Del Campo A, d'Ischia M.
Multifunctional Thin Films and Coatings from Caffeic Acid and a Cross-Linking Diamine.
Langmuir. 2017 Mar 7;33(9):2096-2102. doi: 10.1021/acs.langmuir.6b04079. Epub 2017 Feb 17. PMID: 28191981.
8: Farrukh A, Paez JI, Salierno M, Fan W, Berninger B, Del Campo A.
Bifunctional Poly(acrylamide) Hydrogels through Orthogonal Coupling Chemistries.
Biomacromolecules. 2017 Mar 13;18(3):906-913. doi: 10.1021/acs.biomac.6b01784. Epub 2017 Feb 17. PMID: 28147484.
9: Włodarczyk-Biegun MK, Del Campo A.
3D bioprinting of structural proteins.
Biomaterials. 2017 Jul;134:180-201. doi: 10.1016/j.biomaterials.2017.04.019. Epub 2017 Apr 12. PMID: 28477541.
10: Xue L, Sanz B, Luo A, Turner KT, Wang X, Tan D, Zhang R, Du H, Steinhart M, Mijangos C, Guttmann M, Kappl M, Del Campo A.
Hybrid Surface Patterns Mimicking the Design of the Adhesive Toe Pad of Tree Frog.
ACS Nano. 2017 Oct 24;11(10):9711-9719. doi: 10.1021/acsnano.7b04994. Epub 2017 Sep 8. PMID: 28885831; PMCID: PMC5656980.
11: Feng J, Ton XA, Zhao S, Paez JI, Del Campo A.
Mechanically Reinforced Catechol-Containing Hydrogels with Improved Tissue Gluing Performance.
Biomimetics (Basel). 2017 Nov 13;2(4):23. doi: 10.3390/biomimetics2040023. PMID: 31105184; PMCID: PMC6352675.
12: Paez JI, Farrukh A, Ustahüseyin O, Del Campo A.
Biofunctionalization of Poly(acrylamide) Gels.
Methods Mol Biol. 2018;1758:101-114. doi: 10.1007/978-1-4939-7741-3_8. PMID: 29679325.
13: Zhao S, Fan W, Guo X, Xue L, Berninger B, Salierno MJ, Del Campo A.
Microenvironments to study migration and somal translocation in cortical neurons.
Biomaterials. 2018 Feb;156:238-247. doi: 10.1016/j.biomaterials.2017.11.042. Epub 2017 Nov 28. PMID: 29207324.
14: Farrukh A, Fan W, Zhao S, Salierno M, Paez JI, Del Campo A.
Photoactivatable Adhesive Ligands for Light-Guided Neuronal Growth.
Chembiochem. 2018 Jun 18;19(12):1271-1279. doi: 10.1002/cbic.201800118. Epub 2018 May 15. PMID: 29633466.
15: Nair RV, Farrukh A, Del Campo A.
A Photoactivatable α<sub>5</sub> β<sub>1</sub> -Specific Integrin Ligand.
Chembiochem. 2018 Jun 18;19(12):1280-1287. doi: 10.1002/cbic.201800180. Epub 2018 May 30. PMID: 29774654.
16: Sankaran S, Zhao S, Muth C, Paez J, Del Campo A.
Toward Light-Regulated Living Biomaterials.
Adv Sci (Weinh). 2018 Jun 29;5(8):1800383. doi: 10.1002/advs.201800383. PMID: 30128245; PMCID: PMC6097140.
17: Latorre E, Kale S, Casares L, Gómez-González M, Uroz M, Valon L, Nair RV, Garreta E, Montserrat N, Del Campo A, Ladoux B, Arroyo M, Trepat X.
Active superelasticity in three-dimensional epithelia of controlled shape.
Nature. 2018 Nov;563(7730):203-208. doi: 10.1038/s41586-018-0671-4. Epub 2018 Oct 31. Erratum in: Nature. 2021 Apr;592(7856):E30.
PMID: 30401836; PMCID: PMC6520229.
18: Zheng Y, Farrukh A, Del Campo A.
Optoregulated Biointerfaces to Trigger Cellular Responses.
Langmuir. 2018 Dec 4;34(48):14459-14471. doi: 10.1021/acs.langmuir.8b02634. Epub 2018 Nov 20. PMID: 30392367.
19: Farrukh A, Zhao S, Paez JI, Kavyanifar A, Salierno M, Cavalié A, Del Campo A.
In Situ, Light-Guided Axon Growth on Biomaterials via Photoactivatable Laminin Peptidomimetic IK(HANBP)VAV.
ACS Appl Mater Interfaces. 2018 Dec 5;10(48):41129-41137. doi: 10.1021/acsami.8b15517. Epub 2018 Nov 20. PMID: 30387978.
20: Sankaran S, Becker J, Wittmann C, Del Campo A.
Optoregulated Drug Release from an Engineered Living Material: Self-Replenishing Drug Depots for Long-Term, Light-Regulated Delivery.
Small. 2019 Feb;15(5):e1804717. doi: 10.1002/smll.201804717. Epub 2018 Dec 27. PMID: 30589209.
21: Sankaran S, Del Campo A.
Optoregulated Protein Release from an Engineered Living Material.
Adv Biosyst. 2019 Feb;3(2):e1800312. doi: 10.1002/adbi.201800312. Epub 2018 Dec 17. PMID: 32627372.
22: Khan ES, Sankaran S, Paez JI, Muth C, Han MKL, Del Campo A.
Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly.
Adv Sci (Weinh). 2019 Feb 28;6(9):1801982. doi: 10.1002/advs.201801982. PMID: 31065523; PMCID: PMC6498102.
23: Çolak A , Li B , Blass J , Koynov K , Del Campo A , Bennewitz R .
The mechanics of single cross-links which mediate cell attachment at a hydrogel surface.
Nanoscale. 2019 Jun 28;11(24):11596-11604. doi: 10.1039/c9nr01784d. Epub 2019 Jun 6. PMID: 31169854.
24: Li B, Kappl M, Han L, Cui J, Zhou F, Del Campo A.
Goosebumps-Inspired Microgel Patterns with Switchable Adhesion and Friction.
Small. 2019 Aug;15(35):e1902376. doi: 10.1002/smll.201902376. Epub 2019 Jul 16. PMID: 31310426.
25: Oh YJ, Khan ES, Campo AD, Hinterdorfer P, Li B.
Nanoscale Characteristics and Antimicrobial Properties of (SI-ATRP)-Seeded Polymer Brush Surfaces.
ACS Appl Mater Interfaces. 2019 Aug 14;11(32):29312-29319. doi: 10.1021/acsami.9b09885. Epub 2019 Jul 11. PMID: 31259525.
26: Hetmanski JHR, de Belly H, Busnelli I, Waring T, Nair RV, Sokleva V, Dobre O, Cameron A, Gauthier N, Lamaze C, Swift J, Del Campo A, Starborg T,
Zech T, Goetz JG, Paluch EK, Schwartz JM, Caswell PT.
Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration.
Dev Cell. 2019 Nov 18;51(4):460-475.e10. doi: 10.1016/j.devcel.2019.09.006. Epub 2019 Oct 10. PMID: 31607653; PMCID: PMC6863396.
27: Mora-Boza A , Włodarczyk-Biegun MK , Del Campo A , Vázquez-Lasa B , Román JS
Glycerylphytate as an ionic crosslinker for 3D printing of multi-layered scaffolds with improved shape fidelity and biological features.
Biomater Sci. 2019 Dec 17;8(1):506-516. doi: 10.1039/c9bm01271k. PMID: 31764919.
28: Paez JI, Farrukh A, Valbuena-Mendoza R, Włodarczyk-Biegun MK, Del Campo A.
Thiol-Methylsulfone-Based Hydrogels for 3D Cell Encapsulation.
ACS Appl Mater Interfaces. 2020 Feb 19;12(7):8062-8072. doi: 10.1021/acsami.0c00709. Epub 2020 Feb 10. PMID: 31999422.
29: Han L, Zheng Y, Luo H, Feng J, Engstler R, Xue L, Jing G, Deng X, Del Campo A, Cui J.
Macroscopic Self-Evolution of Dynamic Hydrogels to Create Hollow Interiors.
Angew Chem Int Ed Engl. 2020 Mar 27;59(14):5611-5615. doi: 10.1002/anie.201913574. Epub 2020 Jan 29. PMID: 31840399; PMCID: PMC7154692.
30: Khan ES, Sankaran S, Llontop L, Del Campo A.
Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro.
BMC Mol Cell Biol. 2020 Mar 30;21(1):22. doi: 10.1186/s12860-020-00267-0. PMID: 32228452; PMCID: PMC7106624.
31: Włodarczyk-Biegun MK, Paez JI, Villiou M, Feng J, Del Campo A.
Printability study of metal ion crosslinked PEG-catechol based inks.
Biofabrication. 2020 Apr 29;12(3):035009. doi: 10.1088/1758-5090/ab673a. PMID: 31899910.
32: Feng J, Jiang Q, Rogin P, de Oliveira PW, Del Campo A.
Printed Soft Optical Waveguides of PLA Copolymers for Guiding Light into Tissue.
ACS Appl Mater Interfaces. 2020 May 6;12(18):20287-20294. doi: 10.1021/acsami.0c03903. Epub 2020 Apr 23. PMID: 32285657.
33: Weinberg F, Han MKL, Dahmke IN, Del Campo A, de Jonge N.
Anti-correlation of HER2 and focal adhesion complexes in the plasma membrane.
PLoS One. 2020 Jun 8;15(6):e0234430. doi: 10.1371/journal.pone.0234430. PMID: 32511274; PMCID: PMC7279600.
34: Zheng Y , Chen Z , Jiang Q , Feng J , Wu S , Del Campo A .
Near-infrared- light regulated angiogenesis in a 4D hydrogel.
Nanoscale. 2020 Jul 2;12(25):13654-13661. doi: 10.1039/d0nr02552f. PMID: 32567640.
35: Villiou M, Paez JI, Del Campo A.
Photodegradable Hydrogels for Cell Encapsulation and Tissue Adhesion.
ACS Appl Mater Interfaces. 2020 Aug 26;12(34):37862-37872. doi: 10.1021/acsami.0c08568. Epub 2020 Aug 14. PMID: 32805969.
36: Puertas-Bartolomé M, Włodarczyk-Biegun MK, Del Campo A, Vázquez-Lasa B, San Román J.
3D Printing of a Reactive Hydrogel Bio-Ink Using a Static Mixing Tool.
Polymers (Basel). 2020 Aug 31;12(9):1986. doi: 10.3390/polym12091986. PMID: 32878273; PMCID: PMC7564821.
37: Dumitru AC, Mohammed D, Maja M, Yang J, Verstraeten S, Del Campo A, Mingeot- Leclercq MP, Tyteca D, Alsteens D.
Label-Free Imaging of Cholesterol Assemblies Reveals Hidden Nanomechanics of Breast Cancer Cells.
Adv Sci (Weinh). 2020 Oct 8;7(22):2002643. doi: 10.1002/advs.202002643. PMID: 33240781; PMCID: PMC7675049.
38: Zhang J, Zhao R, Li B, Farrukh A, Hoth M, Qu B, Del Campo A.
Micropatterned soft hydrogels to study the interplay of receptors and forces in T cell activation.
Acta Biomater. 2021 Jan 1;119:234-246. doi: 10.1016/j.actbio.2020.10.028. Epub 2020 Oct 21. PMID: 33099024.
39: Escolano JC, Taubenberger AV, Abuhattum S, Schweitzer C, Farrukh A, Del Campo A, Bryant CE, Guck J.
Compliant Substrates Enhance Macrophage Cytokine Release and NLRP3 Inflammasome Formation During Their Pro-Inflammatory Response.
Front Cell Dev Biol. 2021 Mar 29;9:639815. doi: 10.3389/fcell.2021.639815. PMID: 33855019; PMCID: PMC8039395.
40: Latorre E, Kale S, Casares L, Gómez-González M, Uroz M, Valon L, Nair RV, Garreta E, Montserrat N, Del Campo A, Ladoux B, Arroyo M, Trepat X.
Addendum: Active superelasticity in three-dimensional epithelia of controlled shape.
Nature. 2021 Apr;592(7856):E30. doi: 10.1038/s41586-021-03281-0. Erratum for: Nature. 2018 Nov;563(7730):203-208. PMID: 33846613.
41: Zheng Y, Han MKL, Zhao R, Blass J, Zhang J, Zhou DW, Colard-Itté JR, Dattler D, Çolak A, Hoth M, García AJ, Qu B, Bennewitz R, Giuseppone N,
Del Campo A.
Optoregulated force application to cellular receptors using molecular motors.
Nat Commun. 2021 Jun 11;12(1):3580. doi: 10.1038/s41467-021-23815-4. PMID: 34117256; PMCID: PMC8196032.
42: Nair RV, Farrukh A, Del Campo A.
Light-Regulated Angiogenesis via a Phototriggerable VEGF Peptidomimetic.
Adv Healthc Mater. 2021 Jul;10(14):e2100488. doi: 10.1002/adhm.202100488. Epub 2021 Jun 10. PMID: 34110713.
43: Paez JI, de Miguel-Jiménez A, Valbuena-Mendoza R, Rathore A, Jin M, Gläser A, Pearson S, Del Campo A.
Thiol-Methylsulfone-Based Hydrogels for Cell Encapsulation: Reactivity Optimization of Aryl-Methylsulfone Substrate for Fine- Tunable Gelation Rate
and Improved Stability.
Biomacromolecules. 2021 Jul 12;22(7):2874-2886. doi: 10.1021/acs.biomac.1c00256. Epub 2021 Jun 6. PMID: 34096259.
44: Zhao R, Zhou X, Khan ES, Alansary D, Friedmann KS, Yang W, Schwarz EC, Del Campo A, Hoth M, Qu B.
Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices.
Front Immunol. 2021 Aug 17;12:729820. doi: 10.3389/fimmu.2021.729820. PMID: 34484240; PMCID: PMC8416057.
45: Puertas-Bartolomé M, Włodarczyk-Biegun MK, Del Campo A, Vázquez-Lasa B, San Román J.
Development of bioactive catechol functionalized nanoparticles applicable for 3D bioprinting.
Mater Sci Eng C Mater Biol Appl. 2021 Dec;131:112515. doi: 10.1016/j.msec.2021.112515. Epub 2021 Oct 29. PMID: 34857294.
46: Alhayek A, Khan ES, Schönauer E, Däinghaus T, Shafiei R, Voos K, Han MKL, Ducho C, Posselt G, Wessler S, Brandstetter H, Haupenthal J, Del Campo
A, Hirsch AKH.
Inhibition of Collagenase Q1 of <i>Bacillus cereus</i> as a Novel Antivirulence Strategy for the Treatment of Skin-Wound Infections.
Adv Ther (Weinh). 2022 Mar;5(3):2100222. doi: 10.1002/adtp.202100222. Epub 2022 Jan 15. PMID: 35310821; PMCID: PMC7612511.
47: Bhusari S, Sankaran S, Del Campo A.
Regulating Bacterial Behavior within Hydrogels of Tunable Viscoelasticity.
Adv Sci (Weinh). 2022 Jun;9(17):e2106026. doi: 10.1002/advs.202106026. Epub 2022 Apr 11. PMID: 35404519; PMCID: PMC9189655.
48: Li B, Çolak A, Blass J, Han M, Zhang J, Zheng Y, Jiang Q, Bennewitz R, Campo AD.
Molecular stiffness cues of an interpenetrating network hydrogel for cell adhesion.
Mater Today Bio. 2022 Jun 17;15:100323. doi: 10.1016/j.mtbio.2022.100323. PMID: 35782598; PMCID: PMC9243155.
49: Włodarczyk-Biegun MK, Villiou M, Koch M, Muth C, Wang P, Ott J, Del Campo A.
Melt Electrowriting of Graded Porous Scaffolds to Mimic the Matrix Structure of the Human Trabecular Meshwork.
ACS Biomater Sci Eng. 2022 Sep 12;8(9):3899-3911. doi: 10.1021/acsbiomaterials.2c00623. Epub 2022 Aug 19. PMID: 35984428;
PMCID: PMC9472227.
50: de Miguel-Jiménez A, Ebeling B, Paez JI, Fink-Straube C, Pearson S, Del Campo A.
Gelation Kinetics and Mechanical Properties of Thiol-Tetrazole Methylsulfone Hydrogels Designed for Cell Encapsulation.
Macromol Biosci. 2022 Dec 1:e2200419. doi: 10.1002/mabi.202200419. Epub ahead of print. PMID: 36457236.
51: Bhusari S, Kim J, Polizzi K, Sankaran S, Del Campo A.
Encapsulation of bacteria in bilayer Pluronic thin film hydrogels: A safe format for engineered living materials.
Biomater Adv. 2023 Feb;145:213240. doi: 10.1016/j.bioadv.2022.213240. Epub 2022 Dec 20. PMID: 36577192.
AG Diz-Munoz
1: Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD.
Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration.
PLoS Biol. 2016 Jun 9;14(6):e1002474. doi: 10.1371/journal.pbio.1002474. PMID: 27280401; PMCID: PMC4900667.
2: Diz-Muñoz A, Romanczuk P, Yu W, Bergert M, Ivanovitch K, Salbreux G, Heisenberg CP, Paluch EK.
Steering cell migration by alternating blebs and actin-rich protrusions.
BMC Biol. 2016 Sep 2;14(1):74. doi: 10.1186/s12915-016-0294-x. PMID: 27589901; PMCID: PMC5010735.
3: Crest J, Diz-Muñoz A, Chen DY, Fletcher DA, Bilder D.
Organ sculpting by patterned extracellular matrix stiffness.
Elife. 2017 Jun 27;6:e24958. doi: 10.7554/eLife.24958. PMID: 28653906; PMCID: PMC5503509.
4: Diz-Muñoz A, Weiner OD, Fletcher DA.
In pursuit of the mechanics that shape cell surfaces.
Nat Phys. 2018 Jul;14(7):648-652. doi: 10.1038/s41567-018-0187-8. Epub 2018 Jul 4. PMID: 31007706; PMCID: PMC6469718.
5: Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck R, Balmer J, Fiocchi A, Kreutzfeldt M, Merkler D, Iannacone M, Ariga A, Stoffel MH,
Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV.
The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8<sup>+</sup> T cells.
J Exp Med. 2018 Jul 2;215(7):1869-1890. doi: 10.1084/jem.20170896. Epub 2018 Jun 6. PMID: 29875261; PMCID: PMC6028505.
6: Bevilacqua C, Sánchez-Iranzo H, Richter D, Diz-Muñoz A, Prevedel R.
Imaging mechanical properties of sub-micron ECM in live zebrafish using Brillouin microscopy.
Biomed Opt Express. 2019 Feb 25;10(3):1420-1431. doi: 10.1364/BOE.10.001420. PMID: 30891356; PMCID: PMC6420298.
7: Chan CJ, Costanzo M, Ruiz-Herrero T, Mönke G, Petrie RJ, Bergert M, Diz-Muñoz A, Mahadevan L, Hiiragi T.
Hydraulic control of mammalian embryo size and cell fate.
Nature. 2019 Jul;571(7763):112-116. doi: 10.1038/s41586-019-1309-x. Epub 2019 Jun 12. PMID: 31189957.
8: Prevedel R, Diz-Muñoz A, Ruocco G, Antonacci G.
Brillouin microscopy: an emerging tool for mechanobiology.
Nat Methods. 2019 Oct;16(10):969-977. doi: 10.1038/s41592-019-0543-3. Epub 2019 Sep 23. PMID: 31548707.
9: Graziano BR, Town JP, Sitarska E, Nagy TL, Fošnarič M, Penič S, Iglič A, Kralj-Iglič V, Gov NS, Diz-Muñoz A, Weiner OD.
Cell confinement reveals a branched-actin independent circuit for neutrophil polarity.
PLoS Biol. 2019 Oct 10;17(10):e3000457. doi: 10.1371/journal.pbio.3000457. PMID: 31600188; PMCID: PMC6805013.
10: Ficht X, Ruef N, Stolp B, Samson GPB, Moalli F, Page N, Merkler D, Nichols BJ, Diz-Muñoz A, Legler DF, Niggli V, Stein JV.
In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8<sup>+</sup> T Cell-Mediated Host Surveillance.
J Immunol. 2019 Nov 1;203(9):2377-2387. doi: 10.4049/jimmunol.1900075. Epub 2019 Sep 23. PMID: 31548330; PMCID: PMC6820809.
11: Sánchez-Iranzo H, Bevilacqua C, Diz-Muñoz A, Prevedel R.
A 3D Brillouin microscopy dataset of the <i>in-vivo</i> zebrafish eye.
Data Brief. 2020 Mar 17;30:105427. doi: 10.1016/j.dib.2020.105427. PMID: 32274409; PMCID: PMC7132165.
12: Shen Y, Wang X, Lu J, Salfenmoser M, Wirsik NM, Schleussner N, Imle A, Freire Valls A, Radhakrishnan P, Liang J, Wang G, Muley T, Schneider M, Ruiz
de Almodovar C, Diz-Muñoz A, Schmidt T.
Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer.
Cancer Cell. 2020 Jun 8;37(6):800-817.e7. doi: 10.1016/j.ccell.2020.05.005. PMID: 32516590.
13: Sitarska E, Diz-Muñoz A.
Pay attention to membrane tension: Mechanobiology of the cell surface.
Curr Opin Cell Biol. 2020 Oct;66:11-18. doi: 10.1016/j.ceb.2020.04.001. Epub 2020 May 13. PMID: 32416466; PMCID: PMC7594640.
14: Gross-Thebing S, Truszkowski L, Tenbrinck D, Sánchez-Iranzo H, Camelo C, Westerich KJ, Singh A, Maier P, Prengel J, Lange P, Hüwel J, Gaede F,
Sasse R, Vos BE, Betz T, Matis M, Prevedel R, Luschnig S, Diz-Muñoz A, Burger M, Raz E.
Using migrating cells as probes to illuminate features in live embryonic tissues.
Sci Adv. 2020 Dec 4;6(49):eabc5546. doi: 10.1126/sciadv.abc5546. PMID: 33277250; PMCID: PMC7821905.
15: Shen Y, Schmidt T, Diz-Muñoz A.
Protocol on Tissue Preparation and Measurement of Tumor Stiffness in Primary and Metastatic Colorectal Cancer Samples with an Atomic Force
Microscope.
STAR Protoc. 2020 Nov 16;1(3):100167. doi: 10.1016/j.xpro.2020.100167. PMID: 33377061; PMCID: PMC7757366.
16: Bergert M, Lembo S, Sharma S, Russo L, Milovanović D, Gretarsson KH, Börmel M, Neveu PA, Hackett JA, Petsalaki E, Diz-Muñoz A.
Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation.
Cell Stem Cell. 2021 Feb 4;28(2):209-216.e4. doi: 10.1016/j.stem.2020.10.017. Epub 2020 Nov 17. PMID: 33207217; PMCID: PMC7875094.
17: Leithner A, Altenburger LM, Hauschild R, Assen FP, Rottner K, Stradal TEB, Diz-Muñoz A, Stein JV, Sixt M.
Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse.
J Cell Biol. 2021 Apr 5;220(4):e202006081. doi: 10.1083/jcb.202006081. PMID: 33533935; PMCID: PMC7863705.
18: Venkova L, Vishen AS, Lembo S, Srivastava N, Duchamp B, Ruppel A, Williart A, Vassilopoulos S, Deslys A, Garcia Arcos JM, Diz-Muñoz A, Balland M,
Joanny JF, Cuvelier D, Sens P, Piel M.
A mechano-osmotic feedback couples cell volume to the rate of cell deformation.
Elife. 2022 Apr 13;11:e72381. doi: 10.7554/eLife.72381. PMID: 35416768; PMCID: PMC9090331.
19: Kaplan C, Kenny SJ, Chen X, Schöneberg J, Sitarska E, Diz-Muñoz A, Akamatsu M, Xu K, Drubin DG.
Load adaptation by endocytic actin networks.
Mol Biol Cell. 2022 May 15;33(6):ar50. doi: 10.1091/mbc.E21-11-0589. Epub 2022 Apr 7. PMID: 35389747; PMCID: PMC9265150.
20: Sánchez-Iranzo H, Halavatyi A, Diz-Muñoz A.
Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord.
Elife. 2022 Jun 6;11:e75429. doi: 10.7554/eLife.75429. PMID: 35658971; PMCID: PMC9170247.
21: Clark AG, Maitra A, Jacques C, Bergert M, Pérez-González C, Simon A, Lederer L, Diz-Muñoz A, Trepat X, Voituriez R, Vignjevic DM.
Self-generated gradients steer collective migration on viscoelastic collagen networks.
Nat Mater. 2022 Oct;21(10):1200-1210. doi: 10.1038/s41563-022-01259-5. Epub 2022 May 30. PMID: 35637338.
22: Bergert M, Diz-Muñoz A.
Quantification of Apparent Membrane Tension and Membrane-to-Cortex Attachment in Animal Cells Using Atomic Force Microscopy-
Based Force Spectroscopy.
Methods Mol Biol. 2023;2600:45-62. doi: 10.1007/978-1-0716-2851-5_3. PMID: 36587089.
23: Li JH, Trivedi V, Diz-Muñoz A.
Understanding the interplay of membrane trafficking, cell surface mechanics, and stem cell differentiation.
Semin Cell Dev Biol. 2023 Jan 15;133:123-134. doi: 10.1016/j.semcdb.2022.05.010. Epub 2022 May 28. PMID: 35641408; PMCID: PMC9703995.
AG Eaton
1: Aigouy B, Umetsu D, Eaton S.
Segmentation and Quantitative Analysis of Epithelial Tissues.
Methods Mol Biol. 2016;1478:227-239. doi: 10.1007/978-1-4939-6371-3_13. PMID: 27730585.
2: Çiçek IÖ, Karaca S, Brankatschk M, Eaton S, Urlaub H, Shcherbata HR.
Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet.
Genetics. 2016 Mar;202(3):1167-83. doi: 10.1534/genetics.115.185371. Epub 2016 Jan 22. PMID: 26801178; PMCID: PMC4788116.
3: Etournay R, Merkel M, Popović M, Brandl H, Dye NA, Aigouy B, Salbreux G, Eaton S, Jülicher F.
TissueMiner: A multiscale analysis toolkit to quantify how cellular processes create tissue dynamics.
Elife. 2016 May 26;5:e14334. doi: 10.7554/eLife.14334. PMID: 27228153; PMCID: PMC4946903.
4: Bilgin M, Born P, Fezza F, Heimes M, Mastrangelo N, Wagner N, Schultz C, Maccarrone M, Eaton S, Nadler A, Wilm M, Shevchenko A.
Lipid Discovery by Combinatorial Screening and Untargeted LC-MS/MS.
Sci Rep. 2016 Jun 17;6:27920. doi: 10.1038/srep27920. PMID: 27312775; PMCID: PMC4911551.
5: Jülicher F, Eaton S.
Emergence of tissue shape changes from collective cell behaviours.
Semin Cell Dev Biol. 2017 Jul;67:103-112. doi: 10.1016/j.semcdb.2017.04.004. Epub 2017 Apr 25. PMID: 28454767.
6: Blasse C, Saalfeld S, Etournay R, Sagner A, Eaton S, Myers EW.
PreMosa: extracting 2D surfaces from 3D microscopy mosaics.
Bioinformatics. 2017 Aug 15;33(16):2563-2569. doi: 10.1093/bioinformatics/btx195. PMID: 28383656.
7: Dye NA, Popović M, Spannl S, Etournay R, Kainmüller D, Ghosh S, Myers EW, Jülicher F, Eaton S.
Cell dynamics underlying oriented growth of the [Drosophila wing imaginal disc.
Development. 2017 Dec 1;144(23):4406-4421. doi: 10.1242/dev.155069. Epub 2017 Oct 16. PMID: 29038308.
8: Sui L, Alt S, Weigert M, Dye N, Eaton S, Jug F, Myers EW, Jülicher F, Salbreux G, Dahmann C.
Differential lateral and basal tension drive folding of Drosophila wing discs through two distinct mechanisms.
Nat Commun. 2018 Nov 5;9(1):4620. doi: 10.1038/s41467-018-06497-3. PMID: 30397306; PMCID: PMC6218478.
9: Prince E, Kroeger B, Gligorov D, Wilson C, Eaton S, Karch F, Brankatschk M, Maeda RK.
Rab-mediated trafficking in the secondary cells of Drosophila male accessory glands and its role in fecundity.
Traffic. 2019 Feb;20(2):137-151. doi: 10.1111/tra.12622. Epub 2018 Dec 26. PMID: 30426623; PMCID: PMC6492190.
10: Iyer KV, Piscitello-Gómez R, Paijmans J, Jülicher F, Eaton S.
Epithelial Viscoelasticity Is Regulated by Mechanosensitive E-cadherin Turnover.
Curr Biol. 2019 Feb 18;29(4):578-591.e5. doi: 10.1016/j.cub.2019.01.021. Epub 2019 Feb 7. PMID: 30744966.
11: Spannl S, Buhl T, Nellas I, Zeidan SA, Iyer KV, Khaliullina H, Schultz C, Nadler A, Dye NA, Eaton S.
Glycolysis regulates Hedgehog signalling via the plasma membrane potential.
EMBO J. 2020 Nov 2;39(21):e101767. doi: 10.15252/embj.2019101767. Epub 2020 Oct 6. Erratum in: EMBO J. 2021 Apr 1;40(7):e107925.
PMID: 33021744; PMCID: PMC7604625.
12: Mateska I, Nanda K, Dye NA, Alexaki VI, Eaton S.
Range of SHH signaling in adrenal gland is limited by membrane contact to cells with primary cilia.
J Cell Biol. 2020 Dec 7;219(12):e201910087. doi: 10.1083/jcb.201910087. PMID: 33090184; PMCID: PMC7588141.
13: Iyer KV, Taubenberger A, Zeidan SA, Dye NA, Eaton S, Jülicher F.
Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues.
Nat Commun. 2021 Mar 25;12(1):1756. doi: 10.1038/s41467-021-22010-9. PMID: 33767161; PMCID: PMC7994818.
14: Dye NA, Popović M, Iyer KV, Fuhrmann JF, Piscitello-Gómez R, Eaton S, Jülicher F.
Self-organized patterning of cell morphology via mechanosensitive feedback.
Elife. 2021 Mar 26;10:e57964. doi: 10.7554/eLife.57964. PMID: 33769281; PMCID: PMC8133777.
15: Ghosh S, Leng W, Wilsch-Bräuninger M, Barrera-Velázquez M, Léopold P, Eaton S.
A local insulin reservoir in Drosophila alpha cell homologs ensuresdevelopmental progression under nutrient shortage.
Curr Biol. 2022 Apr 25;32(8):1788-1797.e5. doi: 10.1016/j.cub.2022.02.068. Epub 2022 Mar 21. PMID: 35316653.
16: Spannl S, Buhl T, Nellas I, Zeidan SA, Venkatesan Iyer K, Khaliullina H, Schultz C, Nadler A, Dye NA, Eaton S.
Glycolysis regulates Hedgehog signalling via the plasma membrane potential.
EMBO J. 2021 Apr 1;40(7):e107925. doi: 10.15252/embj.2021107925. Erratum for: EMBO J. 2020 Nov 2;39(21):e101767. PMID: 33792087;
PMCID: PMC8013834.
17: Nellas I, Iyer KV, Iglesias-Artola JM, Pippel M, Nadler A, Eaton S, Dye NA.
Hedgehog signaling can enhance glycolytic ATP production in the Drosophila wing disc.
EMBO Rep. 2022 Nov 7;23(11):e54025. doi: 10.15252/embr.202154025. Epub 2022 Sep 22. PMID: 36134875; PMCID: PMC9638854.
AG Ebnet
1: Franz J, Brinkmann BF, König M, Hüve J, Stock C, Ebnet K, Riethmüller C.
Nanoscale Imaging Reveals a Tetraspanin-CD9 Coordinated Elevation of Endothelial ICAM-1 Clusters.
PLoS One. 2016 Jan 5;11(1):e0146598. doi: 10.1371/journal.pone.0146598. PMID: 26731655; PMCID: PMC4701507.
2: Squarr AJ, Brinkmann K, Chen B, Steinbacher T, Ebnet K, Rosen MK, Bogdan S.
Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation.
J Cell Biol. 2016 Feb 29;212(5):591-603. doi: 10.1083/jcb.201508081. Epub 2016 Feb 22. Erratum in: J Cell Biol. 2016 Mar 28;212(7):883.
PMID: 26903538; PMCID: PMC4772498.
3: Tuncay H, Ebnet K.
Cell adhesion molecule control of planar spindle orientation.
Cell Mol Life Sci. 2016 Mar;73(6):1195-207. doi: 10.1007/s00018-015-2116-7. Epub 2015 Dec 23. PMID: 26698907.
4: Brinkmann BF, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, Nakayama M, Weide T, Gerke V, Ebnet K.
VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation.
Mol Biol Cell. 2016 Sep 15;27(18):2811-21. doi: 10.1091/mbc.E16-02-0127. Epub 2016 Jul 27. PMID: 27466317; PMCID: PMC5025268.
5: Fededa JP, Esk C, Mierzwa B, Stanyte R, Yuan S, Zheng H, Ebnet K, Yan W, Knoblich JA, Gerlich DW.
MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development.
EMBO J. 2016 Nov 15;35(22):2386-2398. doi: 10.15252/embj.201694056. Epub 2016 Oct 5. PMID: 27707753; PMCID: PMC5109238.
6: Ebnet K.
Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With Pleiotropic Functions in Cell Physiology and Development.
Physiol Rev. 2017 Oct 1;97(4):1529-1554. doi: 10.1152/physrev.00004.2017. PMID: 28931565.
7: Kummer D, Ebnet K.
Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection.
Cells. 2018 Mar 26;7(4):25. doi: 10.3390/cells7040025. PMID: 29587442; PMCID: PMC5946102.
8: Steinbacher T, Kummer D, Ebnet K.
Junctional adhesion molecule-A: functional diversity through molecular promiscuity.
Cell Mol Life Sci. 2018 Apr;75(8):1393-1409. doi: 10.1007/s00018-017-2729-0. Epub 2017 Dec 14. PMID: 29238845.
9: Ebnet K, Kummer D, Steinbacher T, Singh A, Nakayama M, Matis M.
Regulation of cell polarity by cell adhesion receptors.
Semin Cell Dev Biol. 2018 Sep;81:2-12. doi: 10.1016/j.semcdb.2017.07.032. Epub 2017 Jul 22. PMID: 28739340.
10: Steinbacher T, Ebnet K.
The regulation of junctional actin dynamics by cell adhesion receptors.
Histochem Cell Biol. 2018 Oct;150(4):341-350. doi: 10.1007/s00418-018-1691-8. Epub 2018 Jul 5. PMID: 29978321.
11: Riddell M, Nakayama A, Hikita T, Mirzapourshafiyi F, Kawamura T, Pasha A, Li M, Masuzawa M, Looso M, Steinbacher T, Ebnet K, Potente M, Hirose T,
Ohno S, Fleming I, Gattenlöhner S, Aung PP, Phung T, Yamasaki O, Yanagi T, Umemura H, Nakayama M.
aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA- binding ability.
Nat Commun. 2018 Dec 17;9(1):5357. doi: 10.1038/s41467-018-07739-0. PMID: 30559384; PMCID: PMC6297234.
12: Otani T, Nguyen TP, Tokuda S, Sugihara K, Sugawara T, Furuse K, Miura T, Ebnet K, Furuse M.
Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity.
J Cell Biol. 2019 Oct 7;218(10):3372-3396. doi: 10.1083/jcb.201812157. Epub 2019 Aug 29. PMID: 31467165; PMCID: PMC6781433.
13: Merlen G, Kahale N, Ursic-Bedoya J, Bidault-Jourdainne V, Simerabet H, Doignon I, Tanfin Z, Garcin I, Péan N, Gautherot J, Davit-Spraul A, Guettier C,
Humbert L, Rainteau D, Ebnet K, Ullmer C, Cassio D, Tordjmann T.
TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function.
Gut. 2020 Jan;69(1):146-157. doi: 10.1136/gutjnl-2018-316975. Epub 2019 Feb 5. PMID: 30723104.
14: Hartmann C, Schwietzer YA, Kummer D, Kirschnick N, Hoppe E, Thüring EM, Glaesner-Ebnet M, Brinkmann F, Gerke V, Reuter S, Nakayama M,
Ebnet K.
The mitochondrial outer membrane protein SYNJ2BP interacts with the cell adhesion molecule TMIGD1 and can recruit it to mitochondria.
BMC Mol Cell Biol. 2020 Apr 17;21(1):30. doi: 10.1186/s12860-020-00274-1. PMID: 32303178; PMCID: PMC7164261.
15: Haas AJ, Zihni C, Ruppel A, Hartmann C, Ebnet K, Tada M, Balda MS, Matter K.
Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly.
Cell Rep. 2020 Jul 21;32(3):107924. doi: 10.1016/j.celrep.2020.107924. PMID: 32697990; PMCID: PMC7383227.
16: Kummer D, Steinbacher T, Schwietzer MF, Thölmann S, Ebnet K.
Tetraspanins: integrating cell surface receptors to functional microdomains in homeostasis and disease.
Med Microbiol Immunol. 2020 Aug;209(4):397-405. doi: 10.1007/s00430-020-00673-3. Epub 2020 Apr 9. PMID: 32274581; PMCID: PMC7395057.
17: Hartmann C, Schwietzer YA, Otani T, Furuse M, Ebnet K.
Physiological functions of junctional adhesion molecules (JAMs) in tight junctions.
Biochim Biophys Acta Biomembr. 2020 Sep 1;1862(9):183299. doi: 10.1016/j.bbamem.2020.183299. Epub 2020 Apr 2. PMID: 32247783.
18: Thölmann S, Seebach J, Otani T, Florin L, Schnittler H, Gerke V, Furuse M, Ebnet K.
JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells.
Cell Mol Life Sci. 2022 Jan 24;79(2):88. doi: 10.1007/s00018-022-04140-5. PMID: 35067832; PMCID: PMC8784505.
19: Kummer D, Steinbacher T, Thölmann S, Schwietzer MF, Hartmann C, Horenkamp S, Demuth S, Peddibhotla SSD, Brinkmann F, Kemper B,
Schnekenburger J, Brandt M, Betz T, Liashkovich I, Kouzel IU, Shahin V, Corvaia N, Rottner K, Tarbashevich K, Raz E, Greune L, Schmidt MA, Gerke V,
Ebnet K.
A JAM-A-tetraspanin-αvβ5 integrin complex regulates contact inhibition of locomotion.
J Cell Biol. 2022 Apr 4;221(4):e202105147. doi: 10.1083/jcb.202105147. Epub 2022 Mar 16. PMID: 35293964; PMCID: PMC8931538.
20: Ebnet K, Gerke V.
Rho and Rab Family Small GTPases in the Regulation of Membrane Polarity in Epithelial Cells.
Front Cell Dev Biol. 2022 Jul 4;10:948013. doi: 10.3389/fcell.2022.948013. PMID: 35859901; PMCID: PMC9289151.
21: Hartmann C, Thüring EM, Greune L, Michels BE, Pajonczyk D, Leußink S, Brinkmann F, Glaesner-Ebnet M, Wardelmann E, Zobel T, Schmidt MA,
Janssen KP, Gerke V, Ebnet K.
Intestinal brush border formation requires a TMIGD1-based intermicrovillar adhesion complex.
Sci Signal. 2022 Sep 13;15(751):eabm2449. doi: 10.1126/scisignal.abm2449. Epub 2022 Sep 13. PMID: 36099341.
22: Schwietzer MF, Thölmann S, Kummer D, Kaschler A, Greune L, Thüring EM, Schmidt MA, Gerke V, Ebnet K.
Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfment.
iScience. 2022 Sep 16;25(10):105144. doi: 10.1016/j.isci.2022.105144. PMID: 36185363; PMCID: PMC9519618.
AG Graeter
1: Lippok S, Kolšek K, Löf A, Eggert D, Vanderlinden W, Müller JP, König G, Obser T, Röhrs K, Schneppenheim S, Budde U, Baldauf C, Aponte-Santamaría
C, Gräter F, Schneppenheim R, Rädler JO, Brehm MA.
von Willebrand factor is dimerized by protein disulfide isomerase.
Blood. 2016 Mar 3;127(9):1183-91. doi: 10.1182/blood-2015-04-641902. Epub 2015 Dec 15. PMID: 26670633.
2: Tursch A, Mercadante D, Tennigkeit J, Gräter F, Özbek S.
Minicollagen cysteine-rich domains encode distinct modes of polymerization to form stable nematocyst capsules.
Sci Rep. 2016 May 11;6:25709. doi: 10.1038/srep25709. PMID: 27166560; PMCID: PMC4863159.
3: Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm MA, Gruber HJ, Netz RR, Baldauf C,
Schneppenheim R, Tampé R, Hinterdorfer P.
Single molecule force spectroscopy data and BD- and MD simulations on the blood protein von Willebrand factor.
Data Brief. 2016 Jul 21;8:1080-7. doi: 10.1016/j.dib.2016.07.031. PMID: 27508268; PMCID: PMC4970544.
4: Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm MA, Gruber HJ, Netz RR, Baldauf C,
Schneppenheim R, Tampé R, Hinterdorfer P.
Mutual A domain interactions in the force sensing protein von Willebrand factor.
J Struct Biol. 2017 Jan;197(1):57-64. doi: 10.1016/j.jsb.2016.04.012. Epub 2016 Apr 23. PMID: 27113902.
5: Costescu BI, Sturm S, Gräter F.
Dynamic disorder can explain non-exponential kinetics of fast protein mechanical unfolding.
J Struct Biol. 2017 Jan;197(1):43-49. doi: 10.1016/j.jsb.2016.10.003. Epub 2016 Oct 19. PMID: 27771331.
6: Aponte-Santamaría C, Lippok S, Mittag JJ, Obser T, Schneppenheim R, Baldauf C, Gräter F, Budde U, Rädler JO.
Mutation G1629E Increases von Willebrand Factor Cleavage via a Cooperative Destabilization Mechanism.
Biophys J. 2017 Jan 10;112(1):57-65. doi: 10.1016/j.bpj.2016.11.3202. PMID: 28076816; PMCID: PMC5232862.
7: Zhou B, Hogg PJ, Gräter F.
One-Way Allosteric Communication between the Two Disulfide Bonds in Tissue Factor.
Biophys J. 2017 Jan 10;112(1):78-86. doi: 10.1016/j.bpj.2016.12.003. PMID: 28076818; PMCID: PMC5232894.
8: Cruz-Chú ER, Xiao S, Patil SP, Gkagkas K, Gräter F.
Organic Filling Mitigates Flaw-Sensitivity of Nanoscale Aragonite.
ACS Biomater Sci Eng. 2017 Mar 13;3(3):260-268. doi: 10.1021/acsbiomaterials.6b00504. Epub 2017 Jan 20. PMID: 33465925.
9: Fuertes G, Banterle N, Ruff KM, Chowdhury A, Mercadante D, Koehler C, Kachala M, Estrada Girona G, Milles S, Mishra A, Onck PR, Gräter F, Esteban-
Martín S, Pappu RV, Svergun DI, Lemke EA.
Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements.
Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6342-E6351. doi: 10.1073/pnas.1704692114. Epub 2017 Jul 17. PMID: 28716919; PMCID: PMC5547626.
10: Kolšek K, Aponte-Santamaría C, Gräter F.
Accessibility explains preferred thiol-disulfide isomerization in a protein domain.
Sci Rep. 2017 Aug 29;7(1):9858. doi: 10.1038/s41598-017-07501-4. PMID: 28851879; PMCID: PMC5575259.
11: Mercadante D, Wagner JA, Aramburu IV, Lemke EA, Gräter F.
Sampling Long- versus Short-Range Interactions Defines the Ability of Force Fields To Reproduce the Dynamics of Intrinsically Disordered Proteins.
J Chem Theory Comput. 2017 Sep 12;13(9):3964-3974. doi: 10.1021/acs.jctc.7b00143. Epub 2017 Aug 28. PMID: 28805390.
12: Daday C, Kolšek K, Gräter F.
The mechano-sensing role of the unique SH3 insertion in plakin domains revealed by Molecular Dynamics simulations.
Sci Rep. 2017 Sep 15;7(1):11669. doi: 10.1038/s41598-017-11017-2. PMID: 28916774; PMCID: PMC5601466.
13: Aponte-Santamaría C, Brunken J, Gräter F.
Stress Propagation through Biological Lipid Bilayers in Silico.
J Am Chem Soc. 2017 Oct 4;139(39):13588-13591. doi: 10.1021/jacs.7b04724. Epub 2017 Sep 25. PMID: 28853287.
14: Wagner JA, Patil SP, Greving I, Lämmel M, Gkagkas K, Seydel T, Müller M, Markert B, Gräter F.
Stress-induced long-range ordering in spider silk.
Sci Rep. v2017 Nov 10;7(1):15273. doi: 10.1038/s41598-017-15384-8. PMID: 29127324; PMCID: PMC5681667.
15: Ray A , Gräter F , Thukral L .
Probing molecular forces in multi-component physiological membranes.
Phys Chem Chem Phys. 2018 Jan 24;20(4):2155-2161. doi: 10.1039/c7cp05981g. PMID: 29177331.
16: Imber M, Huyen NTT, Pietrzyk-Brzezinska AJ, Loi VV, Hillion M, Bernhardt J, Thärichen L, Kolšek K, Saleh M, Hamilton CJ, Adrian L, Gräter F, Wahl
MC, Antelmann H.
Protein S-Bacillithiolation Functions in Thiol Protection and Redox Regulation of the Glyceraldehyde-3-Phosphate Dehydrogenase Gap in Staphylococcus
aureus Under Hypochlorite Stress.
Antioxid Redox Signal. 2018 Feb 20;28(6):410-430. doi: 10.1089/ars.2016.6897. Epub 2017 Jan 18. PMID: 27967218; PMCID: PMC5791933.
17: Butera D, Passam F, Ju L, Cook KM, Woon H, Aponte-Santamaría C, Gardiner E, Davis AK, Murphy DA, Bronowska A, Luken BM, Baldauf C, Jackson S,
Andrews R, Gräter F, Hogg PJ.
Autoregulation of von Willebrand factor function by a disulfide bond switch.
Sci Adv. 2018 Feb 28;4(2):eaaq1477. doi: 10.1126/sciadv.aaq1477. PMID: 29507883; PMCID: PMC5834005.
18: Mercadante D, Gräter F, Daday C.
CONAN: A Tool to Decode Dynamical Information from Molecular Interaction Maps.
Biophys J. 2018 Mar 27;114(6):1267-1273. doi: 10.1016/j.bpj.2018.01.033. PMID: 29590584; PMCID: PMC5883949.
19: Passam F, Chiu J, Ju L, Pijning A, Jahan Z, Mor-Cohen R, Yeheskel A, Kolšek K, Thärichen L, Aponte-Santamaría C, Gräter F, Hogg PJ.
Mechano-redox control of integrin de-adhesion.
Elife. 2018 Jun 22;7:e34843. doi: 10.7554/eLife.34843. PMID: 29932420; PMCID: PMC6054529.
20: Gräter F, Li W.
Studying Functional Disulphide Bonds by Computer Simulations.
Methods Mol Biol. 2019;1967:87-113. doi: 10.1007/978-1-4939-9187-7_6. PMID: 31069766.
21: Xu ER, von Bülow S, Chen PC, Lenting PJ, Kolšek K, Aponte-Santamaría C, Simon B, Foot J, Obser T, Schneppenheim R, Gräter F, Denis CV, Wilmanns
M, Hennig J.
Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor.
Blood. 2019 Jan 24;133(4):366-376. doi: 10.1182/blood-2018-04-843615. Epub 2018 Oct 10. PMID: 30305279; PMCID: PMC6450055.
22: Daday C, Mateyka LM, Gräter F.
How ARVC-Related Mutations Destabilize Desmoplakin: An MD Study.
Biophys J. 2019 Mar 5;116(5):831-835. doi: 10.1016/j.bpj.2019.01.023. Epub 2019 Jan 30. PMID: 30773294; PMCID: PMC6403075.
23: Bauer MS, Baumann F, Daday C, Redondo P, Durner E, Jobst MA, Milles LF, Mercadante D, Pippig DA, Gaub HE, Gräter F, Lietha D.
Structural and mechanistic insights into mechanoactivation of focal adhesion kinase.
Proc Natl Acad Sci U S 6774. 2019 Apr 2;116(14):6766-6774. doi: 10.1073/pnas.1820567116. Epub 2019 Mar 15. PMID: 30877242; PMCID: PMC6452671.
24: Sheridan S, Gräter F, Daday C.
How Fast Is Too Fast in Force-Probe Molecular Dynamics Simulations?
J Phys Chem B. 2019 May 2;123(17):3658-3664. doi: 10.1021/acs.jpcb.9b01251. Epub 2019 Apr 22. PMID: 30970209.
25: Herrera-Rodríguez AM, Miletić V, Aponte-Santamaría C, Gräter F.
Molecular Dynamics Simulations of Molecules in Uniform Flow.
Biophys J. 2019 May 7;116(9):1579-1585. doi: 10.1016/j.bpj.2018.12.025. Epub 2019 Feb 8. PMID: 30975453; PMCID: PMC6506623.
26: Zhang Y , Xia K , Cao Z , Gräter F , Xia F .
A new method for the construction of coarse-grained models of large biomolecules from low-resolution cryo-electron microscopy data.
Phys Chem Chem Phys. 2019 May 15;21(19):9720-9727. doi: 10.1039/c9cp01370a. PMID: 31025999.
27: Caetano-Anollés G, Aziz MF, Mughal F, Gräter F, Koç I, Caetano-Anollés K, Caetano-Anollés D.
Emergence of Hierarchical Modularity in Evolving Networks Uncovered by Phylogenomic Analysis.
Evol Bioinform Online. 2019 Sep 5;15:1176934319872980. doi: 10.1177/1176934319872980. PMID: 31523127; PMCID: PMC6728656.
28: Suman SK, Daday C, Ferraro T, Vuong-Brender T, Tak S, Quintin S, Robin F, Gräter F, Labouesse M.
The plakin domain of C. elegans VAB-10/plectin acts as a hub in a mechanotransduction pathway to promote morphogenesis.
Development. 2019 Dec 13;146(24):dev183780. doi: 10.1242/dev.183780. PMID: 31784459; PMCID: PMC7375825.
29: Rennekamp B, Kutzki F, Obarska-Kosinska A, Zapp C, Gräter F. Hybrid Kinetic
Monte Carlo/Molecular Dynamics Simulations of Bond Scissions in Proteins.
J Chem Theory Comput. 2020 Jan 14;16(1):553-563. doi: 10.1021/acs.jctc.9b00786. Epub 2019 Dec 4. PMID: 31738552.
30: Franz F, Daday C, Gräter F.
Advances in molecular simulations of protein mechanical properties and function.
Curr Opin Struct Biol. 2020 Apr;61:132-138. doi: 10.1016/j.sbi.2019.12.015. Epub 2020 Jan 15. PMID: 31954324.
31: Zapp C, Obarska-Kosinska A, Rennekamp B, Kurth M, Hudson DM, Mercadante D, Barayeu U, Dick TP, Denysenkov V, Prisner T, Bennati M, Daday C,
Kappl R, Gräter F.
Mechanoradicals in tensed tendon collagen as a source of oxidative stress.
Nat Commun. 2020 May 8;11(1):2315. doi: 10.1038/s41467-020-15567-4. PMID: 32385229; PMCID: PMC7210969.
32: Acebrón I, Righetto RD, Schoenherr C, de Buhr S, Redondo P, Culley J, Rodríguez CF, Daday C, Biyani N, Llorca O, Byron A, Chami M, Gräter F,
Boskovic J, Frame MC, Stahlberg H, Lietha D.
Structural basis of Focal Adhesion Kinase activation on lipid membranes.
EMBO J. 2020 Oct 1;39(19):e104743. doi: 10.15252/embj.2020104743. Epub 2020 Aug 11. PMID: 32779739; PMCID: PMC7527928.
33: Zha J, Zhang Y, Xia K, Gräter F, Xia F.
Coarse-Grained Simulation of Mechanical Properties of Single Microtubules With Micrometer Length.
Front Mol Biosci. 2021 Feb 15;7:632122. doi: 10.3389/fmolb.2020.632122. PMID: 33659274; PMCID: PMC7917235.
34: Jin F, Gräter F.
How multisite phosphorylation impacts the conformations of intrinsically disordered proteins.
PLoS Comput Biol. 2021 May 4;17(5):e1008939. doi: 10.1371/journal.pcbi.1008939. PMID: 33945530; PMCID: PMC8148376.
35: Banterle N, Nievergelt AP, de Buhr S, Hatzopoulos GN, Brillard C, Andany S, Hübscher T, Sorgenfrei FA, Schwarz US, Gräter F, Fantner GE, Gönczy P.
Kinetic and structural roles for the surface in guiding SAS-6 self-assembly to direct centriole architecture.
Nat Commun. 2021 Oct 26;12(1):6180. doi: 10.1038/s41467-021-26329-1. PMID: 34702818; PMCID: PMC8548535.
36: Michelarakis N, Franz F, Gkagkas K, Gräter F.
Longitudinal strand ordering leads to shear thinning in Nafion.
Phys Chem Chem Phys. 2021 Nov 24;23(45):25901-25910. doi: 10.1039/d1cp02024b. PMID: 34779459.
37: Maag D, Putzu M, Gómez-Flores CL, Gräter F, Elstner M, Kubař T.
Electrostatic interactions contribute to the control of intramolecular thiol- disulfide isomerization in a protein.
Phys Chem Chem Phys. 2021 Dec 1;23(46):26366-26375. doi: 10.1039/d1cp03129e. PMID: 34792054.
38: Martin IM, Aponte-Santamaría C, Schmidt L, Hedtfeld M, Iusupov A, Musacchio A, Gräter F.
Phosphorylation tunes elongation propensity and cohesiveness of INCENP's intrinsically disordered region.
J Mol Biol. 2022 Jan 15;434(1):167387. doi: 10.1016/j.jmb.2021.167387. Epub 2021 Dec 6. PMID: 34883116.
39: Huck V, Chen PC, Xu ER, Tischer A, Klemm U, Aponte-Santamaría C, Mess C, Obser T, Kutzki F, König G, Denis CV, Gräter F, Wilmanns M, Auton M,
Schneider SW, Schneppenheim R, Hennig J, Brehm MA.
Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics.
Thromb Haemost. 2022 Feb;122(2):226-239. doi: 10.1055/a-1344-4405. Epub 2021 Apr 14. PMID: 33385180; PMCID: PMC8828397.
40: Gómez-Flores CL, Maag D, Kansari M, Vuong VQ, Irle S, Gräter F, Kubař T, Elstner M.
Accurate Free Energies for Complex Condensed-Phase Reactions Using an Artificial Neural Network Corrected DFTB/MM Methodology.
J Chem Theory Comput. 2022 Feb 8;18(2):1213-1226. doi: 10.1021/acs.jctc.1c00811. Epub 2022 Jan 3. PMID: 34978438.
41: Daday C, de Buhr S, Mercadante D, Gräter F.
Mechanical force can enhance c-Src kinase activity by impairing autoinhibition.
Biophys J. 2022 Mar 1;121(5):684-691. doi: 10.1016/j.bpj.2022.01.028. Epub 2022 Feb 2. PMID: 35120901; PMCID: PMC8943751.
42: Martin IM, Nava MM, Wickström SA, Gräter F.
ATP allosterically stabilizes integrin-linked kinase for efficient force generation.
Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2106098119. doi: 10.1073/pnas.2106098119. Epub 2022 Mar 8. PMID: 35259013; PMCID: PMC8933812.
43: Brosz M, Michelarakis N, Bunz UHF, Aponte-Santamaría C, Gräter F.
Martini 3 coarse-grained force field for poly(para-phenylene ethynylene)s.
Phys Chem Chem Phys. 2022 May 4;24(17):9998-10010. doi: 10.1039/d1cp04237h. PMID: 35412534.
44: Gruber S, Löf A, Hausch A, Kutzki F, Jöhr R, Obser T, König G, Schneppenheim R, Aponte-Santamaría C, Gräter F, Brehm MA, Benoit M, Lipfert J.
A conformational transition of the D'D3 domain primes von Willebrand factor for multimerization.
Blood Adv. 2022 Sep 13;6(17):5198-5209. doi: 10.1182/bloodadvances.2022006978. PMID: 36069828; PMCID: PMC9631632.
45: Chen PC, Kutzki F, Mojzisch A, Simon B, Xu ER, Aponte-Santamaría C, Horny K, Jeffries C, Schneppenheim R, Wilmanns M, Brehm MA, Gräter F,
Hennig J.
Structure and dynamics of the von Willebrand Factor C6 domain.
J Struct Biol. 2022 Dec;214(4):107923. doi: 10.1016/j.jsb.2022.107923. Epub 2022 Nov 18. PMID: 36410652.
46: Treyde W, Riedmiller K, Gräter F.
Bond dissociation energies of X-H bonds in proteins.
RSC Adv. 2022 Dec 1;12(53):34557-34564. doi: 10.1039/d2ra04002f. PMID: 36545577; PMCID: PMC9713614.
AG Grashoff
1: Freikamp A, Cost AL, Grashoff C.
The Piconewton Force Awakens: Quantifying Mechanics in Cells.
Trends Cell Biol. 2016 Nov;26(11):838-847. doi: 10.1016/j.tcb.2016.07.005. Epub 2016 Aug 17. PMID: 27544876.
2: Freikamp A, Mehlich A, Klingner C, Grashoff C.
Investigating piconewton forces in cells by FRET-based molecular force microscopy.
J Struct Biol. 2017 Jan;197(1):37-42. doi: 10.1016/j.jsb.2016.03.011. Epub 2016 Mar 12. PMID: 26980477.
3: Ringer P, Weißl A, Cost AL, Freikamp A, Sabass B, Mehlich A, Tramier M, Rief M, Grashoff C.
Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1.
Nat Methods. 2017 Nov;14(11):1090-1096. doi: 10.1038/nmeth.4431. Epub 2017 Sep 18. PMID: 28945706.
4: Ringer P, Colo G, Fässler R, Grashoff C.
Sensing the mechano-chemical properties of the extracellular matrix.
Matrix Biol. 2017 Dec;64:6-16. doi: 10.1016/j.matbio.2017.03.004. Epub 2017 Apr 4. PMID: 28389162.
5: Price AJ, Cost AL, Ungewiß H, Waschke J, Dunn AR, Grashoff C.
Mechanical loading of desmosomes depends on the magnitude and orientation of external stress.
Nat Commun. 2018 Dec 11;9(1):5284. doi: 10.1038/s41467-018-07523-0. PMID: 30538252; PMCID: PMC6290003.
6: Lemke SB, Weidemann T, Cost AL, Grashoff C, Schnorrer F.
A small proportion of Talin molecules transmit forces at developing muscle attachments in vivo.
PLoS Biol. 2019 Mar 27;17(3):e3000057. doi: 10.1371/journal.pbio.3000057. PMID: 30917109; PMCID: PMC6453563.
7: Kanoldt V, Fischer L, Grashoff C.
Unforgettable force - crosstalk and memory of mechanosensitive structures.
Biol Chem. 2019 May 27;400(6):687-698. doi: 10.1515/hsz-2018-0328. PMID: 30465711.
8: Cost AL, Khalaji S, Grashoff C.
Genetically Encoded FRET-Based Tension Sensors.
Curr Protoc Cell Biol. 2019 Jun;83(1):e85. doi: 10.1002/cpcb.85. Epub 2019 Mar 13. PMID: 30865383.
9: Kanoldt V, Kluger C, Barz C, Schweizer AL, Ramanujam D, Windgasse L, Engelhardt S, Chrostek-Grashoff A, Grashoff C.
Metavinculin modulates force transduction in cell adhesion sites.
Nat Commun. 2020 Dec 17;11(1):6403. doi: 10.1038/s41467-020-20125-z. PMID: 33335089; PMCID: PMC7747745.
10: Fischer LS, Klingner C, Schlichthaerle T, Strauss MT, Böttcher R, Fässler R, Jungmann R, Grashoff C.
Quantitative single-protein imaging reveals molecular complex formation of integrin, talin, and kindlin during cell adhesion.
Nat Commun. 2021 Feb 10;12(1):919. doi: 10.1038/s41467-021-21142-2. PMID: 33568673; PMCID: PMC7876120.
11: Arif N, Zinnhardt M, Nyamay'Antu A, Teber D, Brückner R, Schaefer K, Li YT, Trappmann B, Grashoff C, Vestweber D.
PECAM-1 supports leukocyte diapedesis by tension-dependent dephosphorylation of VE-cadherin.
EMBO J. 2021 May 3;40(9):e106113. doi: 10.15252/embj.2020106113. Epub 2021 Feb 19. PMID: 33604918; PMCID: PMC8090850.
12: Fischer LS, Rangarajan S, Sadhanasatish T, Grashoff C.
Molecular Force Measurement with Tension Sensors.
Annu Rev Biophys. 2021 May 6;50:595-616. doi: 10.1146/annurev-biophys-101920-064756. Epub 2021 Mar 12. PMID: 33710908.
13: Fischer LS, Schlichthaerle T, Chrostek-Grashoff A, Grashoff C.
Peptide-PAINT Enables Investigation of Endogenous Talin with Molecular Scale Resolution in Cells and Tissues. Chembiochem.
2021 Oct 1;22(19):2872-2879. doi: 10.1002/cbic.202100301. Epub 2021 Jul 30. PMID: 34286903; PMCID: PMC8518977.
14: Glogowska E, Arhatte M, Chatelain FC, Lesage F, Xu A, Grashoff C,
Discher DE, Patel A, Honoré E. Piezo1 and Piezo2 foster mechanical gating of K<sub>2P</sub> channels.
Cell Rep. 2021 Nov 30;37(9):110070. doi: 10.1016/j.celrep.2021.110070. PMID: 34852225.
15: Windgasse L, Grashoff C.
Multiplexed Molecular Tension Sensor Measurements Using PIE-FLIM.
Methods Mol Biol. 2023;2600:221-237. doi: 10.1007/978-1-0716-2851-5_15. PMID: 36587101.
16: Bauer N, Maisuls I, Pereira da Graça A, Reinhardt D, Erapaneedi R, Kirschnick N, Schäfers M, Grashoff C, Landfester K, Vestweber D, Strassert CA,
Kiefer F.
Genetically encoded dual fluorophore reporters for graded oxygen- sensing in light microscopy.
Biosens Bioelectron. 2023 Feb 1;221:114917. doi: 10.1016/j.bios.2022.114917. Epub 2022 Nov 17. PMID: 36450170.
AG Grill/Knust
1: Naganathan SR, Middelkoop TC, Fürthauer S, Grill SW.
Actomyosin-driven left- right asymmetry: from molecular torques to chiral self organization.
Curr Opin Cell Biol. 2016 Feb;38:24-30. doi: 10.1016/j.ceb.2016.01.004. Epub 2016 Jan 30. PMID: 26829488.
2: Saha A, Nishikawa M, Behrndt M, Heisenberg CP, Jülicher F, Grill SW.
Determining Physical Properties of the Cell Cortex.
Biophys J. 2016 Mar 29;110(6):1421-9. doi: 10.1016/j.bpj.2016.02.013. PMID: 27028651; PMCID: PMC4816702.
3: Reymann AC, Staniscia F, Erzberger A, Salbreux G, Grill SW.
Cortical flow aligns actin filaments to form a furrow.
Elife. 2016 Oct 10;5:e17807. doi: 10.7554/eLife.17807. PMID: 27719759; PMCID: PMC5117871.
4: Nishikawa M, Naganathan SR, Jülicher F, Grill SW.
Controlling contractile instabilities in the actomyosin cortex.
Elife. 2017 Jan 28;6:e19595. doi: 10.7554/eLife.19595. Erratum in: Elife. 2017 Jul 19;6: PMID: 28117665; PMCID: PMC5354522.
5: Acharya BR, Wu SK, Lieu ZZ, Parton RG, Grill SW, Bershadsky AD, Gomez GA, Yap AS.
Mammalian Diaphanous 1 Mediates a Pathway for E-cadherin to Stabilize Epithelial Barriers through Junctional Contractility.
Cell Rep. 2017 Mar 21;18(12):2854-2867. doi: 10.1016/j.celrep.2017.02.078. PMID: 28329679.
6: Gross P, Kumar KV, Grill SW.
How Active Mechanics and Regulatory Biochemistry Combine to Form Patterns in Development.
Annu Rev Biophys. 2017 May 22;46:337-356. doi: 10.1146/annurev-biophys-070816-033602. PMID: 28532214.
7: Reuther C, Mittasch M, Naganathan SR, Grill SW, Diez S.
Highly-Efficient Guiding of Motile Microtubules on Non-Topographical Motor Patterns. Nano Lett.
2017 Sep 13;17(9):5699-5705. doi: 10.1021/acs.nanolett.7b02606. Epub 2017 Aug 23. PMID: 28819981.
8: Mittasch M, Gross P, Nestler M, Fritsch AW, Iserman C, Kar M, Munder M, Voigt A, Alberti S, Grill SW, Kreysing M.
Non-invasive perturbations of intracellular flow reveal physical principles of cell organization.
Nat Cell Biol. 2018 Mar;20(3):344-351. doi: 10.1038/s41556-017-0032-9. Epub 2018 Feb 5. PMID: 29403036.
9: Naganathan SR, Fürthauer S, Rodriguez J, Fievet BT, Jülicher F, Ahringer J, Cannistraci CV, Grill SW.
Morphogenetic degeneracies in the actomyosin cortex.
Elife. 2018 Oct 22;7:e37677. doi: 10.7554/eLife.37677. PMID: 30346273; PMCID: PMC6226289.
10: Klinkert K, Levernier N, Gross P, Gentili C, von Tobel L, Pierron M, Busso C, Herrman S, Grill SW, Kruse K, Gönczy P.
Aurora A depletion reveals centrosome-independent polarization mechanism in Caenorhabditis elegans.
Elife. 2019 Feb 26;8:e44552. doi: 10.7554/eLife.44552. PMID: 30801250; PMCID: PMC6417861.
11: Gross P, Kumar KV, Goehring NW, Bois JS, Hoege C, Jülicher F, Grill SW.
Guiding self-organized pattern formation in cell polarity establishment. Nat
Phys. 2019 Jul 2;15(3):293-300. doi: 10.1038/s41567-018-0358-7. Epub 2018 Dec 3. PMID: 31327978; PMCID: PMC6640039.
12: Pimpale LG, Middelkoop TC, Mietke A, Grill SW.
Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early Caenorhabditis elegans development.
Elife. 2020 Jul 9;9:e54930. doi: 10.7554/eLife.54930. PMID: 32644039; PMCID: PMC7394549.
13: Jain A, Ulman V, Mukherjee A, Prakash M, Cuenca MB, Pimpale LG, Münster S, Haase R, Panfilio KA, Jug F, Grill SW, Tomancak P, Pavlopoulos A.
Regionalized tissue fluidization is required for epithelial gap closure during insect gastrulation.
Nat Commun. 2020 Nov 5;11(1):5604. doi: 10.1038/s41467-020-19356-x. PMID: 33154375; PMCID: PMC7645651.
14: Renger R, Morin JA, Lemaitre R, Ruer-Gruss M, Jülicher F, Hermann A, Grill SW.
Co-condensation of proteins with single- and double-stranded DNA.
Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2107871119. doi: 10.1073/pnas.2107871119. Epub 2022 Mar 1. PMID: 35238639; PMCID: PMC8915884.
15: Najafabadi FR, Leaver M, Grill SW.
Orchestrating nonmuscle myosin II filament assembly at the onset of cytokinesis.
Mol Biol Cell. 2022 Jul 1;33(8):ar74. doi: 10.1091/mbc.E21-12-0599. Epub 2022 May 11. PMID: 35544301; PMCID: PMC9635286.
16: Yan VT, Narayanan A, Wiegand T, Jülicher F, Grill SW.
A condensate dynamic instability orchestrates actomyosin cortex activation.
Nature. 2022 Sep;609(7927):597-604. doi: 10.1038/s41586-022-05084-3. Epub 2022 Aug 17. PMID: 35978196; PMCID: PMC9477739.
17: Sarov M, Barz C, Jambor H, Hein MY, Schmied C, Suchold D, Stender B, Janosch S, K J VV, Krishnan RT, Krishnamoorthy A, Ferreira IR, Ejsmont RK,
Finkl K, Hasse S, Kämpfer P, Plewka N, Vinis E, Schloissnig S, Knust E, Hartenstein V, Mann M, Ramaswami M, VijayRaghavan K, Tomancak P, Schnorrer F.
A genome-wide resource for the analysis of protein localisation in Drosophila.
Elife. 2016 Feb 20;5:e12068. doi: 10.7554/eLife.12068. PMID: 26896675; PMCID: PMC4805545.
18: Flores-Benitez D, Knust E.
Dynamics of epithelial cell polarity in Drosophila: how to regulate the regulators?
Curr Opin Cell Biol. 2016 Oct;42:13-21. doi: 10.1016/j.ceb.2016.03.018. Epub 2016 Apr 14. PMID: 27085003.
19: Nemetschke L, Knust E.
Drosophila Crumbs prevents ectopic Notch activation in developing wings by inhibiting ligand-independent endocytosis.
Development. 2016 Dec 1;143(23):4543-4553. doi: 10.1242/dev.141762. PMID: 27899511.
20: Spannl S, Kumichel A, Hebbar S, Kapp K, Gonzalez-Gaitan M, Winkler S, Blawid R, Jessberger G, Knust E.
The Crumbs_C isoform of <i>Drosophila</i> shows tissue- and stage-specific expression and prevents light-dependent retinal
degeneration.
Biol Open. 2017 Feb 15;6(2):165-175. doi: 10.1242/bio.020040. PMID: 28202468; PMCID: PMC5312091.
21: Das S, Knust E.
Stardust, the Janus-faced partner of Crumbs.
J Cell Biol. 2017 May 1;216(5):1219-1221. doi: 10.1083/jcb.201704023. Epub 2017 Apr 17. PMID: 28416478; PMCID: PMC5412578.
22: Das S, Knust E.
A dual role of the extracellular domain of Drosophila Crumbs for morphogenesis of the embryonic neuroectoderm.
Biol Open. 2018 Jan 26;7(1):bio031435. doi: 10.1242/bio.031435. PMID: 29374056; PMCID: PMC5829512.
23: Tsoumpekos G, Nemetschke L, Knust E.
Drosophila Big bang regulates the apical cytocortex and wing growth through junctional tension.
J Cell Biol. 2018 Mar 5;217(3):1033-1045. doi: 10.1083/jcb.201705104. Epub 2018 Jan 11. PMID: 29326288; PMCID: PMC5839783.
24: Crespo C, Soroldoni D, Knust E.
A novel transgenic zebrafish line for red opsin expression in outer segments of photoreceptor cells.
Dev Dyn. 2018 Jul;247(7):951-959. doi: 10.1002/dvdy.24631. Epub 2018 Apr 23. PMID: 29603474; PMCID: PMC6099204.
25: Crespo C, Knust E.
Characterisation of maturation of photoreceptor cell subtypes during zebrafish retinal development.
Biol Open. 2018 Oct 31;7(11):bio036632. doi: 10.1242/bio.036632. PMID: 30237290; PMCID: PMC6262866.
26: Lehmann M, Knust E, Hebbar S.
Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa.
Methods Mol Biol. 2019;1834:221-249. doi: 10.1007/978-1-4939-8669-9_16. PMID: 30324448.
27: Mishra M, Knust E.
Analysis of the Drosophila Compound Eye with Light and Electron Microscopy.
Methods Mol Biol. 2019;1834:345-364. doi: 10.1007/978-1-4939-8669-9_22. PMID: 30324454.
28: Skouloudaki K, Papadopoulos DK, Tomancak P, Knust E.
The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation.
PLoS Genet. 2019 Jan 15;15(1):e1007852. doi: 10.1371/journal.pgen.1007852. PMID: 30645584; PMCID: PMC6333334.
29: Kujawski S, Sonawane M, Knust E.
penner/lgl2 is required for the integrity of the photoreceptor layer in the zebrafish retina.
Biol Open. 2019 Apr 23;8(4):bio041830. doi: 10.1242/bio.041830. PMID: 31015218; PMCID: PMC6503998.
30: Skouloudaki K, Christodoulou I, Khalili D, Tsarouhas V, Samakovlis C, Tomancak P, Knust E, Papadopoulos DK.
Yorkie controls tube length and apical barrier integrity during airway development.
J Cell Biol. 2019 Aug 5;218(8):2762-2781. doi: 10.1083/jcb.201809121. Epub 2019 Jul 17. PMID: 31315941; PMCID: PMC6683733.
31: Bajur AT, Iyer KV, Knust E.
Cytocortex-dependent dynamics of Drosophila Crumbs controls junctional stability and tension during germ band retraction.
J Cell Sci. 2019 Aug 7;132(15):jcs228338. doi: 10.1242/jcs.228338. PMID: 31300472.
32: Hartenstein V, Yuan M, Younossi-Hartenstein A, Karandikar A, Bernardo-Garcia FJ, Sprecher S, Knust E.
Serial electron microscopic reconstruction of the drosophila larval eye: Photoreceptors with a rudimentary rhabdomere of microvillar-like processes.
Dev Biol. 2019 Sep 1;453(1):56-67. doi: 10.1016/j.ydbio.2019.05.017. Epub 2019 May 31. PMID: 31158364; PMCID: PMC6667290.
33: Lattner J, Leng W, Knust E, Brankatschk M, Flores-Benitez D.
Crumbs organizes the transport machinery by regulating apical levels of PI(4,5)P<sub>2</sub> in Drosophila.
Elife. 2019 Nov 7;8:e50900. doi: 10.7554/eLife.50900. PMID: 31697234; PMCID: PMC6881148.
34: Kraut RS, Knust E.
Changes in endolysosomal organization define a pre- degenerative state in the crumbs mutant Drosophila retina.
PLoS One. 2019 Dec 13;14(12):e0220220. doi: 10.1371/journal.pone.0220220. PMID: 31834921; PMCID: PMC6910688.
35: Kujawski S, Crespo C, Luz M, Yuan M, Winkler S, Knust E.
Loss of Crb2b-lf leads to anterior segment defects in old zebrafish.
Biol Open. 2020 Feb 11;9(2):bio047555. doi: 10.1242/bio.047555. PMID: 31988089; PMCID: PMC7044448.
36: Raghuraman BK, Hebbar S, Kumar M, Moon H, Henry I, Knust E, Shevchenko A.
Absolute Quantification of Proteins in the Eye of Drosophila melanogaster.
Proteomics. 2020 Dec;20(23):e1900049. doi: 10.1002/pmic.201900049. Epub 2020 Sep3. PMID: 32663363.
37: Hebbar S, Schuhmann K, Shevchenko A, Knust E.
Hydroxylated sphingolipid biosynthesis regulates photoreceptor apical domain morphogenesis.
J Cell Biol. 2020 Dec 7;219(12):e201911100. doi: 10.1083/jcb.201911100. PMID: 33048164; PMCID: PMC7557679.
38: Bhagavatula S, Knust E.
A putative stem-loop structure in Drosophila crumbs is required for mRNA localisation in epithelia and germline cells.
J Cell Sci. 2021 Jan 25;134(2):jcs236497. doi: 10.1242/jcs.236497. PMID: 33310910.
39: Hebbar S, Lehmann M, Behrens S, Hälsig C, Leng W, Yuan M, Winkler S, Knust E.
Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila.
Biol Open. 2021 Jan 25;10(1):bio052332. doi: 10.1242/bio.052332. PMID: 33495354; PMCID: PMC7860132.
40: Hebbar S, Knust E.
Reactive oxygen species (ROS) constitute an additional player in regulating epithelial development.
Bioessays. 2021 Aug;43(8):e2100096. doi: 10.1002/bies.202100096. Epub 2021 Jul 14. PMID: 34260754.
AG Grosse
1: Grikscheit K, Grosse R.
Formins at the Junction.
Trends Biochem Sci. 2016 Feb;41(2):148-159. doi: 10.1016/j.tibs.2015.12.002. Epub 2015 Dec 28. PMID: 26732401.
2: Melak M, Plessner M, Grosse R.
Actin visualization at a glance.
J Cell Sci. 2017 Feb 1;130(3):525-530. doi: 10.1242/jcs.189068. Epub 2017 Jan 12. Erratum in: J Cell Sci. 2017 May 1;130(9):1688. PMID: 28082420.
3: Brandt A, Grikscheit K, Siede R, Grosse R, Meixner MD, Büchler R.
Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin.
Sci Rep. 2017 Jul 5;7(1):4673. doi: 10.1038/s41598-017-04734-1. PMID: 28680118; PMCID: PMC5498664.
4: Hinojosa LS, Holst M, Baarlink C, Grosse R.
MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion.
J Cell Biol. 2017 Oct 2;216(10):3087-3095. doi: 10.1083/jcb.201702010. Epub 2017 Aug 3. PMID: 28774893; PMCID: PMC5626544.
5: Baarlink C, Plessner M, Sherrard A, Morita K, Misu S, Virant D, Kleinschnitz EM, Harniman R, Alibhai D, Baumeister S, Miyamoto K, Endesfelder U, Kaidi
A, Grosse R.
A transient pool of nuclear F-actin at mitotic exit controls chromatin organization.
Nat Cell Biol. 2017 Dec;19(12):1389-1399. doi: 10.1038/ncb3641. Epub 2017 Nov 13. PMID: 29131140.
6: Grobe H, Wüstenhagen A, Baarlink C, Grosse R, Grikscheit K.
A Rac1-FMNL2 signaling module affects cell-cell contact formation independent of Cdc42 and membrane protrusions.
PLoS One. 2018 Mar 26;13(3):e0194716. doi: 10.1371/journal.pone.0194716. PMID: 29579104; PMCID: PMC5868805.
7: Dorn T, Kornherr J, Parrotta EI, Zawada D, Ayetey H, Santamaria G, Iop L, Mastantuono E, Sinnecker D, Goedel A, Dirschinger RJ, My I, Laue S, Bozoglu
T, Baarlink C, Ziegler T, Graf E, Hinkel R, Cuda G, Kääb S, Grace AA, Grosse R, Kupatt C, Meitinger T, Smith AG, Laugwitz KL, Moretti A.
Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity.
EMBO J. 2018 Jun 15;37(12):e98133. doi: 10.15252/embj.201798133. Epub 2018 May 15. PMID: 29764980; PMCID: PMC6003642.
8: Plessner M, Grosse R.
Dynamizing nuclear actin filaments.
Curr Opin Cell Biol. 2019 Feb;56:1-6. doi: 10.1016/j.ceb.2018.08.005. Epub 2018 Sep 5. PMID: 30193156.
9: Plessner M, Knerr J, Grosse R.
Centrosomal Actin Assembly Is Required for Proper Mitotic Spindle Formation and Chromosome Congression.
iScience. 2019 May 31;15:274-281. doi: 10.1016/j.isci.2019.04.022. Epub 2019 Apr 28. PMID: 31096079; PMCID: PMC6520610.
10: Caridi CP, Plessner M, Grosse R, Chiolo I.
Nuclear actin filaments in DNA repair dynamics.
Nat Cell Biol. 2019 Sep;21(9):1068-1077. doi: 10.1038/s41556-019-0379-1. Epub 2019 Sep 3. PMID: 31481797; PMCID: PMC6736642.
11: Almonacid M, Al Jord A, El-Hayek S, Othmani A, Coulpier F, Lemoine S, Miyamoto K, Grosse R, Klein C, Piolot T, Mailly P, Voituriez R, Genovesio A,
Verlhac MH.
Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes.
Dev Cell. 2019 Oct 21;51(2):145-157.e10. doi: 10.1016/j.devcel.2019.09.010. Epub 2019 Oct 10. PMID: 31607652.
12: Wang Y, Sherrard A, Zhao B, Melak M, Trautwein J, Kleinschnitz EM, Tsopoulidis N, Fackler OT, Schwan C, Grosse R.
GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics.
Nat Commun. 2019 Nov 21;10(1):5271. doi: 10.1038/s41467-019-13322-y. PMID: 31754104; PMCID: PMC6872576.
13: Yamazaki S, Gerhold C, Yamamoto K, Ueno Y, Grosse R, Miyamoto K, Harata M.
The Actin-Family Protein Arp4 Is a Novel Suppressor for the Formation and Functions of Nuclear F-Actin.
Cells. 2020 Mar 19;9(3):758. doi: 10.3390/cells9030758. PMID: 32204557; PMCID: PMC7140684.
14: Taskinen ME, Närvä E, Conway JRW, Hinojosa LS, Lilla S, Mai A, De Franceschi N, Elo LL, Grosse R, Zanivan S, Norman JC, Ivaska J.
MASTL promotes cell contractility and motility through kinase-independent signaling.
J Cell Biol. 2020 Jun 1;219(6):e201906204. doi: 10.1083/jcb.201906204. PMID: 32311005; PMCID: PMC7265322.
15: Okuno T, Li WY, Hatano Y, Takasu A, Sakamoto Y, Yamamoto M, Ikeda Z, Shindo T, Plessner M, Morita K, Matsumoto K, Yamagata K, Grosse R,
Miyamoto K. Zygotic
Nuclear F-Actin Safeguards Embryonic Development.
Cell Rep. 2020 Jun 30;31(13):107824. doi: 10.1016/j.celrep.2020.107824. PMID: 32610125.
16: Schiavon CR, Zhang T, Zhao B, Moore AS, Wales P, Andrade LR, Wu M, Sung TC, Dayn Y, Feng JW, Quintero OA, Shadel GS, Grosse R, Manor U.
Actin chromobody imaging reveals sub-organellar actin dynamics.
Nat Methods. 2020 Sep;17(9):917-921. doi: 10.1038/s41592-020-0926-5. Epub 2020 Aug 10. PMID: 32778832; PMCID: PMC7746311.
17: Krippner S, Winkelmeier J, Knerr J, Brandt DT, Virant D, Schwan C, Endesfelder U, Grosse R.
Postmitotic expansion of cell nuclei requires nuclear actin filament bundling by α-actinin 4.
EMBO Rep. 2020 Nov 5;21(11):e50758. doi: 10.15252/embr.202050758. Epub 2020 Sep 22. PMID: 32959960; PMCID: PMC7645226.
18: Schwan C, Grosse R.
A tight grip on differentiation: Nuclear constriction by microtubules regulates hematopoietic stem cells.
EMBO J. 2020 Dec 1;39(23):e107086. doi: 10.15252/embj.2020107086. Epub 2020 Nov 19. PMID: 33210291; PMCID: PMC7705448.
19: Kepser LJ, Khudayberdiev S, Hinojosa LS, Macchi C, Ruscica M, Marcello E, Culmsee C, Grosse R, Rust MB.
Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts.
Sci Rep. 2021 Feb 26;11(1):4789. doi: 10.1038/s41598-021-84213-w. PMID: 33637797; PMCID: PMC7910472.
20: Ulferts S, Prajapati B, Grosse R, Vartiainen MK.
Emerging Properties and Functions of Actin and Actin Filaments Inside the Nucleus.
Cold Spring Harb Perspect Biol. 2021 Mar 1;13(3):a040121. doi: 10.1101/cshperspect.a040121. PMID: 33288541; PMCID: PMC7919393.
21: Safaralizade M, Fuderer R, Grosse R, Zhao B.
Measuring nuclear calcium and actin assembly in living cells.
J Biochem. 2021 Apr 18;169(3):287-294. doi: 10.1093/jb/mvab002. PMID: 33479753.
22: Zhao B, Grosse R.
Optogenetic Control of Myocardin-Related Transcription Factor A Subcellular Localization and Transcriptional Activity Steers Membrane Blebbing and
Invasive Cancer Cell Motility.
Adv Biol (Weinh). 2021 May;5(5):e2000208. doi: 10.1002/adbi.202000208. Epub 2021 Feb 8. PMID: 34028209.
23: Trefzer R, Elpeleg O, Gabrusskaya T, Stepensky P, Mor-Shaked H, Grosse R, Brandt DT.
Characterization of a L136P mutation in Formin-like 2 (FMNL2) from a patient with chronic inflammatory bowel disease.
PLoS One. 2021 May 27;16(5):e0252428. doi: 10.1371/journal.pone.0252428. PMID: 34043722; PMCID: PMC8158924.
24: Liang P, Schmitz C, Lace B, Ditengou FA, Su C, Schulze E, Knerr J, Grosse R, Keller J, Libourel C, Delaux PM, Ott T.
Formin-mediated bridging of cell wall, plasma membrane, and cytoskeleton in symbiotic infections of Medicago truncatula.
Curr Biol. 2021 Jun 21;31(12):2712-2719.e5. doi: 10.1016/j.cub.2021.04.002. Epub 2021 Apr 29. PMID: 33930305; PMCID: PMC8231094.
25: Kowarschik S, Schöllkopf J, Müller T, Tian S, Knerr J, Bakker H, Rein S, Dong M, Weber S, Grosse R, Schmidt G.
Yersinia pseudotuberculosis cytotoxic necrotizing factor interacts with glycosaminoglycans.
FASEB J. 2021 Jul;35(7):e21647. doi: 10.1096/fj.202001630R. PMID: 34165206.
26: Weigang S, Fuchs J, Zimmer G, Schnepf D, Kern L, Beer J, Luxenburger H, Ankerhold J, Falcone V, Kemming J, Hofmann M, Thimme R, Neumann-
Haefelin C, Ulferts S, Grosse R, Hornuss D, Tanriver Y, Rieg S, Wagner D, Huzly D, Schwemmle M, Panning M, Kochs G.
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants. Nat Commun. 2021 Nov
4;12(1):6405. doi: 10.1038/s41467-021-26602-3. PMID: 34737266; PMCID: PMC8568958.
27: Frank D, Moussie JC, Ulferts S, Lorenzen L, Schwan C, Grosse R.
Vesicle- Associated Actin Assembly by Formins Promotes TGFβ-Induced ANGPTL4 Trafficking, Secretion and Cell Invasion. Adv Sci (Weinh).
2023 Jan 24:e2204896. doi: 10.1002/advs.202204896. Epub ahead of print. PMID: 36691769.
AGs Grosshans/Wolf
1: Lv Z, Großhans J.
A Radial Actin Network in Apical Constriction.
Dev Cell. 2016 Nov 7;39(3):280-282. doi: 10.1016/j.devcel.2016.10.017. PMID: 27825436.
2: Liu B, Grosshans J.
Link of Zygotic Genome Activation and Cell Cycle Control.
Methods Mol Biol. 2017;1605:11-30. doi: 10.1007/978-1-4939-6988-3_2. PMID: 28456955.
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PLoS Biol. 2017 Dec 4;15(12):e2003315. doi: 10.1371/journal.pbio.2003315. PMID: 29206227; PMCID: PMC5730382.
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Biophys J. 2017 Dec 19;113(12):2601-2608. doi: 10.1016/j.bpj.2017.10.025. Epub 2017 Nov 10. PMID: 29129266; PMCID: PMC5770989.
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Biophys J. 2017 Dec 19;113(12):2796-2804. doi: 10.1016/j.bpj.2017.08.061. PMID: 29262372; PMCID: PMC5770988.
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Nucleus. 2018 Jan 1;9(1):104-118. doi: 10.1080/19491034.2017.1412028. PMID: 29210315; PMCID: PMC5973253.
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Development. 2018 Jan 26;145(2):dev157909. doi: 10.1242/dev.157909. PMID: 29361564.
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Overexpression of the lamina proteins Lamin and Kugelkern induces specific ultrastructural alterations in the morphology of the nuclear envelope of
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A Link between Deoxyribonucleotide Metabolites and Embryonic Cell-Cycle Control.
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Dynamic Gain Analysis Reveals Encoding Deficiencies in Cortical Neurons That Recover from Hypoxia-Induced Spreading Depolarizations.
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Tipping the Scales: Peptide- Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer's Disease.
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The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma.
J Exp Med. 2017 Feb;214(2):339-358. doi: 10.1084/jem.20160596. Epub 2017 Jan 17. PMID: 28096290; PMCID: PMC5294851.
4: Rahn E, Thier K, Petermann P, Rübsam M, Staeheli P, Iden S, Niessen CM, Knebel-Mörsdorf D.
Epithelial Barriers in Murine Skin during Herpes Simplex Virus 1 Infection: The Role of Tight Junction Formation.
J Invest Dermatol. 2017 Apr;137(4):884-893. doi: 10.1016/j.jid.2016.11.027. Epub 2016 Dec 6. PMID: 27939379.
5: Vorhagen S, Kleefisch D, Persa OD, Graband A, Schwickert A, Saynisch M, Leitges M, Niessen CM, Iden S.
Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis.
Oncogene. 2018 Sep;37(37):5136-5146. doi: 10.1038/s41388-018-0313-1. Epub 2018 May 23. PMID: 29789715; PMCID: PMC6137026.
6: Dias Gomes M, Letzian S, Saynisch M, Iden S.
Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity.
Nat Commun. 2019 Jul 29;10(1):3362. doi: 10.1038/s41467-019-11325-3. PMID: 31358743; PMCID: PMC6662827.
7: Li M, Knapp SK, Iden S.
Mechanisms of melanocyte polarity and differentiation: What can we learn from other neuroectoderm-derived lineages?
Curr Opin Cell Biol. 2020 Dec;67:99-108. doi: 10.1016/j.ceb.2020.09.001. Epub 2020 Oct 21. PMID: 33099084.
8: Li M, Iden S.
Emerging Laminin-332‒Dependent and ‒Independent Roles for Integrin α3 in Protumorigenic Signaling.
J Invest Dermatol. 2021 Apr;141(4):713-716. doi: 10.1016/j.jid.2020.08.017. PMID: 33752808.
9: Dias Gomes M, Iden S.
Orchestration of tissue-scale mechanics and fate decisions by polarity signalling.
EMBO J. 2021 Jun 15;40(12):e106787. doi: 10.15252/embj.2020106787. Epub 2021 May 17. PMID: 33998017; PMCID: PMC8204866.
10: Jung P, Zhou X, Iden S, Bischoff M, Qu B.
T cell stiffness is enhanced upon formation of immunological synapse.
Elife. 2021 Jul 27;10:e66643. doi: 10.7554/eLife.66643. PMID: 34313220; PMCID: PMC8360652.
11: Koehler S, Odenthal J, Ludwig V, Unnersjö Jess D, Höhne M, Jüngst C, Grawe F, Helmstädter M, Janku JL, Bergmann C, Hoyer PF, Hagmann HH, Walz
G, Bloch W, Niessen C, Schermer B, Wodarz A, Denholm B, Benzing T, Iden S, Brinkkoetter PT.
Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to
maintain the kidney filtration barrier.
Kidney Int. 2022 Apr;101(4):733-751. doi: 10.1016/j.kint.2021.11.030. Epub 2021 Dec 17. PMID: 34929254.
12: Jung P, Zhou X, Iden S, Qu B, Bischoff M.
Characterization of the Elasticity of CD4<sup>+</sup> T Cells: An Approach Based on Peak Force Quantitative Nanomechanical Mapping.
Bio Protoc. 2022 Apr 20;12(8):e4383. doi: 10.21769/BioProtoc.4383. PMID: 35800101; PMCID: PMC9081480.
13: Baess SC, Burkhart AK, Cappello S, Graband A, Seré K, Zenke M, Niemann C, Iden S.
Lrig1- and Wnt-dependent niches dictate segregation of resident immune cells and melanocytes in murine tail epidermis. Development.
2022 Jul 15;149(14):dev200154. doi: 10.1242/dev.200154. Epub 2022 Jul 14. PMID: 35815643; PMCID: PMC9382897.
14: Friedmann KS, Kaschek L, Knörck A, Cappello S, Lünsmann N, Küchler N, Hoxha C, Schäfer G, Iden S, Bogeski I, Kummerow C, Schwarz EC, Hoth M.
Interdependence of sequential cytotoxic T lymphocyte and natural killer cell cytotoxicity against melanoma cells.
J Physiol. 2022 Dec;600(23):5027-5054. doi: 10.1113/JP283667. Epub 2022 Nov 3. PMID: 36226443.
AG Janshoff
1: Baronsky T, Dzementsei A, Oelkers M, Melchert J, Pieler T, Janshoff A.
Reduction in E-cadherin expression fosters migration of Xenopus laevis primordial germ cells.
Integr Biol (Camb). 2016 Mar 14;8(3):349-58. doi: 10.1039/c5ib00291e. PMID: 26907205.
2: Witt H, Savić F, Oelkers M, Awan SI, Werz DB, Geil B, Janshoff A.
Size, Kinetics, and Free Energy of Clusters Formed by Ultraweak Carbohydrate- Carbohydrate Bonds.
Biophys J. 2016 Apr 12;110(7):1582-1592. doi: 10.1016/j.bpj.2016.03.006. PMID: 27074683; PMCID: PMC4833834.
3: Savić F, Kliesch TT, Verbeek S, Bao C, Thiart J, Kros A, Geil B, Janshoff A.
Geometry of the Contact Zone between Fused Membrane-Coated Beads Mimicking Cell- Cell Fusion.
Biophys J. 2016 May 24;110(10):2216-28. doi: 10.1016/j.bpj.2016.04.026. PMID: 27224487; PMCID: PMC4880807.
4: Lambertz C, Martos A, Henkel A, Neiser A, Kliesch TT, Janshoff A, Schwille P, Sönnichsen C.
Single Particle Plasmon Sensors as Label-Free Technique To Monitor MinDE Protein Wave Propagation on Membranes.
Nano Lett. 2016 Jun 8;16(6):3540-4. doi: 10.1021/acs.nanolett.6b00507. Epub 2016 May 19. PMID: 27172130.
5: Gleisner M, Kroppen B, Fricke C, Teske N, Kliesch TT, Janshoff A, Meinecke M, Steinem C.
Epsin N-terminal Homology Domain (ENTH) Activity as a Function of Membrane Tension.
J Biol Chem. 2016 Sep 16;291(38):19953-61. doi: 10.1074/jbc.M116.731612. Epub 2016 Jul 27. PMID: 27466364; PMCID: PMC5025682.
6: Oelkers M, Witt H, Halder P, Jahn R, Janshoff A.
SNARE-mediated membrane fusion trajectories derived from force-clamp experiments.
Proc Natl Acad Sci U S 2016 Nov 15;113(46):13051-13056. doi: 10.1073/pnas.1615885113. Epub 2016 Nov 2. PMID: 27807132;
PMCID: PMC5135348.
7: Block J, Witt H, Candelli A, Peterman EJ, Wuite GJ, Janshoff A, Köster S.
Nonlinear Loading-Rate-Dependent Force Response of Individual Vimentin Intermediate Filaments to Applied Strain.
Phys Rev Lett. 2017 Jan 27;118(4):048101. doi: 10.1103/PhysRevLett.118.048101. Epub 2017 Jan 24. PMID: 28186786.
8: Brückner BR, Nöding H, Janshoff A.
Viscoelastic Properties of Confluent MDCK II Cells Obtained from Force Cycle Experiments.
Biophys J. 2017 Feb 28;112(4):724-735. doi: 10.1016/j.bpj.2016.12.032. PMID: 28256232; PMCID: PMC5340129.
9: Baronsky T, Ruhlandt D, Brückner BR, Schäfer J, Karedla N, Isbaner S, Hähnel D, Gregor I, Enderlein J, Janshoff A, Chizhik AI.
Cell-Substrate Dynamics of the Epithelial-to-Mesenchymal Transition.
Nano Lett. 2017 May 10;17(5):3320-3326. doi: 10.1021/acs.nanolett.7b01558. Epub 2017 Apr 27. PMID: 28440076.
10: Seiwert D, Witt H, Janshoff A, Paulsen H.
The non-bilayer lipid MGDG stabilizes the major light-harvesting complex (LHCII) against unfolding.
Sci Rep. 2017 Jul 11;7(1):5158. doi: 10.1038/s41598-017-05328-7. PMID: 28698661; PMCID: PMC5505961.
11: Schütte OM, Mey I, Enderlein J, Savić F, Geil B, Janshoff A, Steinem C.
Size and mobility of lipid domains tuned by geometrical constraints.
Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6064-E6071. doi: 10.1073/pnas.1704199114. Epub 2017 Jul 10. PMID: 28696315;
PMCID: PMC5544307.
12: Kliesch TT, Dietz J, Turco L, Halder P, Polo E, Tarantola M, Jahn R, Janshoff A.
Membrane tension increases fusion efficiency of model membranes in the presence of SNAREs.
Sci Rep. 2017 Sep 21;7(1):12070. doi: 10.1038/s41598-017-12348-w. PMID: 28935937; PMCID: PMC5608890.
13: Nehls S, Janshoff A.
Elastic Properties of Pore-Spanning Apical Cell Membranes Derived from MDCK II Cells.
Biophys J. 2017 Oct 17;113(8):1822-1830. doi: 10.1016/j.bpj.2017.08.038. PMID: 29045876; PMCID: PMC5647573.
14: Karsch S, Kong D, Großhans J, Janshoff A.
Single-Cell Defects Cause a Long- Range Mechanical Response in a Confluent Epithelial Cell Layer.
Biophys J. 2017 Dec 19;113(12):2601-2608. doi: 10.1016/j.bpj.2017.10.025. Epub 2017 Nov 10. PMID: 29129266; PMCID: PMC5770989.
15: Seiwert D, Witt H, Ritz S, Janshoff A, Paulsen H.
The Nonbilayer Lipid MGDG and the Major Light-Harvesting Complex (LHCII) Promote Membrane Stacking in Supported Lipid Bilayers.
Biochemistry. 2018 Apr 17;57(15):2278-2288. doi: 10.1021/acs.biochem.8b00118. Epub 2018 Apr 3. PMID: 29577715.
16: Nöding H, Schön M, Reinermann C, Dörrer N, Kürschner A, Geil B, Mey I, Heussinger C, Janshoff A, Steinem C.
Rheology of Membrane-Attached Minimal Actin Cortices.
J Phys Chem B. 2018 Apr 26;122(16):4537-4545. doi: 10.1021/acs.jpcb.7b11491. Epub 2018 Apr 13. PMID: 29589937.
17: Block J, Witt H, Candelli A, Danes JC, Peterman EJG, Wuite GJL, Janshoff A, Köster S.
Viscoelastic properties of vimentin originate from nonequilibrium conformational changes.
Sci Adv. 2018 Jun 13;4(6):eaat1161. doi: 10.1126/sciadv.aat1161. PMID: 29928696; PMCID: PMC6007166.
18: Brückner BR, Janshoff A.
Importance of integrity of cell-cell junctions for the mechanics of confluent MDCK II cells.
Sci Rep. 2018 Sep 20;8(1):14117. doi: 10.1038/s41598-018-32421-2. PMID: 30237412; PMCID: PMC6148251.
19: Kamprad N , Witt H , Schröder M , Kreis CT , Bäumchen O , Janshoff A , Tarantola M .
Adhesion strategies of Dictyostelium discoideum- a force spectroscopy study.
Nanoscale. 2018 Dec 21;10(47):22504-22519. doi: 10.1039/c8nr07107a. Epub 2018 Nov 27. PMID: 30480299.
20: Witt H, Janshoff A.
Using Force Spectroscopy to Probe Coiled-Coil Assembly and Membrane Fusion.
Methods Mol Biol. 2019;1860:145-159. doi: 10.1007/978-1-4939-8760-3_8. PMID: 30317502.
21: Nehls S, Nöding H, Karsch S, Ries F, Janshoff A.
Stiffness of MDCK II Cells Depends on Confluency and Cell Size.
Biophys J. 2019 Jun 4;116(11):2204-2211. doi: 10.1016/j.bpj.2019.04.028. Epub 2019 May 16. PMID: 31126583; PMCID: PMC6554486.
22: Brückner BR, Nöding H, Skamrahl M, Janshoff A.
Mechanical and morphological response of confluent epithelial cell layers to reinforcement and dissolution of the F-actin cytoskeleton.
Prog Biophys Mol Biol. 2019 Jul;144:77-90. doi: 10.1016/j.pbiomolbio.2018.08.010. Epub 2018 Sep 7. PMID: 30197289.
23: Forsting J, Kraxner J, Witt H, Janshoff A, Köster S.
Vimentin Intermediate Filaments Undergo Irreversible Conformational Changes during Cyclic Loading.
Nano Lett. 2019 Oct 9;19(10):7349-7356. doi: 10.1021/acs.nanolett.9b02972. Epub 2019 Sep 9. PMID: 31498648.
24: Selvaggio G, Chizhik A, Nißler R, Kuhlemann L, Meyer D, Vuong L, Preiß H, Herrmann N, Mann FA, Lv Z, Oswald TA, Spreinat A, Erpenbeck L,
Großhans J, Karius V, Janshoff A, Pablo Giraldo J, Kruss S.
Exfoliated near infrared fluorescent silicate nanosheets for (bio)photonics.
Nat Commun. 2020 Mar 20;11(1):1495. doi: 10.1038/s41467-020-15299-5. PMID: 32198383; PMCID: PMC7083911.
25: Witt H , Vache M , Cordes A , Janshoff A .
Detachment of giant liposomes - coupling of receptor mobility and membrane shape.
Soft Matter. 2020 Jul 21;16(27):6424-6433. doi: 10.1039/d0sm00863j. Epub 2020 Jun 26. PMID: 32588015.
26: Cordes A, Witt H, Gallemí-Pérez A, Brückner B, Grimm F, Vache M, Oswald T, Bodenschatz J, Flormann D, Lautenschläger F, Tarantola M, Janshoff A.
Prestress and Area Compressibility of Actin Cortices Determine the Viscoelastic Response of Living Cells.
Phys Rev Lett. 2020 Aug 7;125(6):068101. doi: 10.1103/PhysRevLett.125.068101. PMID: 32845697.
27: Hubrich H, Mey IP, Brückner BR, Mühlenbrock P, Nehls S, Grabenhorst L, Oswald T, Steinem C, Janshoff A.
Viscoelasticity of Native and Artificial Actin Cortices Assessed by Nanoindentation Experiments.
Nano Lett. 2020 Sep 9;20(9):6329-6335. doi: 10.1021/acs.nanolett.0c01769. Epub 2020 Aug 13. PMID: 32786944.
28: Karsch S, Büchau F, Magin TM, Janshoff A.
An intact keratin network is crucial for mechanical integrity and barrier function in keratinocyte cell sheets.
Cell Mol Life Sci. 2020 Nov;77(21):4397-4411. doi: 10.1007/s00018-019-03424-7. Epub 2020 Jan 7. PMID: 31912195.
29: Witt H, Savić F, Verbeek S, Dietz J, Tarantola G, Oelkers M, Geil B, Janshoff A.
Membrane fusion studied by colloidal probes.
Eur Biophys J. 2021 Mar;50(2):223-237. doi: 10.1007/s00249-020-01490-5. Epub 2021 Feb 18. PMID: 33599795; PMCID: PMC8071799.
30: Verbeek SF, Awasthi N, Teiwes NK, Mey I, Hub JS, Janshoff A.
How arginine derivatives alter the stability of lipid membranes: dissecting the roles of side chains, backbone and termini.
Eur Biophys J. 2021 Mar;50(2):127-142. doi: 10.1007/s00249-021-01503-x. Epub 2021 Mar 4. PMID: 33661339; PMCID: PMC8071801.
31: de Groot B, Janshoff A, Steinem C, Zweckstetter M.
Special issue: Multicomponent lipid membranes-how molecular organisation leads to function.
Eur Biophys J. 2021 Mar;50(2):107-108. doi: 10.1007/s00249-021-01535-3. PMID: 33860333; PMCID: PMC8071790.
32: Schepers AV, Lorenz C, Nietmann P, Janshoff A, Klumpp S, Köster S.
Multiscale mechanics and temporal evolution of vimentin intermediate filament networks.
Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2102026118. doi: 10.1073/pnas.2102026118. PMID: 34187892; PMCID: PMC8271578.
33: Skamrahl M, Pang H, Ferle M, Gottwald J, Rübeling A, Maraspini R, Honigmann A, Oswald TA, Janshoff A.
Tight Junction ZO Proteins Maintain Tissue Fluidity, Ensuring Efficient Collective Cell Migration.
Adv Sci (Weinh). 2021 Oct;8(19):e2100478. doi: 10.1002/advs.202100478. Epub 2021 Aug 12. PMID: 34382375; PMCID: PMC8498871.
34: Xu H, Wali R, Cheruiyot C, Bodenschatz J, Hasenfuss G, Janshoff A, Habeck M, Ebert A.
Non-negative blind deconvolution for signal processing in a CRISPR- edited iPSC-cardiomyocyte model of dilated cardiomyopathy.
FEBS Lett. 2021 Oct;595(20):2544-2557. doi: 10.1002/1873-3468.14189. Epub 2021 Sep 17. PMID: 34482543.
35: Janshoff A.
Viscoelasticity of basal plasma membranes and cortices derived from MDCK II cells.
Biophys Rep (N Y). 2021 Sep 14;1(2):100024. doi: 10.1016/j.bpr.2021.100024. PMID: 36425463; PMCID: PMC9680774.
36: Menck K, Heinrichs S, Wlochowitz D, Sitte M, Noeding H, Janshoff A, Treiber H, Ruhwedel T, Schatlo B, von der Brelie C, Wiemann S, Pukrop T,
Beißbarth T, Binder C, Bleckmann A.
WNT11/ROR2 signaling is associated with tumor invasion and poor survival in breast cancer.
J Exp Clin Cancer Res. 2021 Dec 15;40(1):395. doi: 10.1186/s13046-021-02187-z. PMID: 34911552; PMCID: PMC8672621.
37: Janshoff A.
Viscoelastic properties of epithelial cells. Biochem Soc Trans.
2021 Dec 17;49(6):2687-2695. doi: 10.1042/BST20210476. PMID: 34854895.
38: Selvaggio G, Nißler R, Nietmann P, Patra A, Patalag LJ, Janshoff A, Werz DB, Kruss S.
NIR-emitting benzene-fused oligo-BODIPYs for bioimaging.
Analyst. 2022 Jan 17;147(2):230-237. doi: 10.1039/d1an01850g. PMID: 34897304.
39: Nietmann P, Bodenschatz JEF, Cordes AM, Gottwald J, Rother-Nöding H, Oswald T, Janshoff A.
Epithelial cells fluidize upon adhesion but display mechanical homeostasis in the adherent state.
Biophys J. 2022 Feb 1;121(3):361-373. doi: 10.1016/j.bpj.2021.12.042. Epub 2022 Jan 5. PMID: 34998827; PMCID: PMC8822618.
40: Dietz J, Oelkers M, Hubrich R, Pérez-Lara A, Jahn R, Steinem C, Janshoff A.
Forces, Kinetics, and Fusion Efficiency Altered by the Full-Length Synaptotagmin-1 -PI(4,5)P<sub>2</sub> Interaction in Constrained Geometries.
Nano Lett. 2022 Feb 9;22(3):1449-1455. doi: 10.1021/acs.nanolett.1c02491. Epub 2021 Dec 2. PMID: 34855407.
41: Bodenschatz JFE, Ajmail K, Skamrahl M, Vache M, Gottwald J, Nehls S, Janshoff A.
Epithelial cells sacrifice excess area to preserve fluidity in response to external mechanical stress.
Commun Biol. 2022 Aug 22;5(1):855. doi: 10.1038/s42003-022-03809-8. PMID: 35995827; PMCID: PMC9395404.
42: Kramer K, Sari M, Schulze K, Flegel H, Stehr M, Mey I, Janshoff A, Steinem C.
From LUVs to GUVs─How to Cover Micrometer-Sized Pores with Membranes.
J Phys Chem B. 2022 Oct 20;126(41):8233-8244. doi: 10.1021/acs.jpcb.2c05685. Epub 2022 Oct 10. PMID: 36210780
AGs Krahn/Weide
1: Cidlinsky N, Dogliotti G, Pukrop T, Jung R, Weber F, Krahn MP.
Inactivation of the LKB1-AMPK signaling pathway does not contribute to salivary gland tumor development - a short report.
Cell Oncol (Dordr). 2016 Aug;39(4):389-96. doi: 10.1007/s13402-016-0290-8. Epub 2016 Aug 1. PMID: 27480082.
2: Koch L, Feicht S, Sun R, Sen A, Krahn MP.
Domain-specific functions of Stardust in Drosophila embryonic development.
R Soc Open Sci. 2016 Nov 16;3(11):160776. doi: 10.1098/rsos.160776. PMID: 28018665; PMCID: PMC5180163.
3: Dogliotti G, Kullmann L, Dhumale P, Thiele C, Panichkina O, Mendl G, Houben R, Haferkamp S, Püschel AW, Krahn MP.
Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.
Nat Commun. 2017 Jun 26;8:15747. doi: 10.1038/ncomms15747. Erratum in: Nat Commun. 2022 Mar 8;13(1):1283.
PMID: 28649994; PMCID: PMC5490199.
4: Weide T, Vollenbröker B, Schulze U, Djuric I, Edeling M, Bonse J, Hochapfel F, Panichkina O, Wennmann DO, George B, Kim S, Daniel C, Seggewiß J,
Amann K, Kriz W, Krahn MP,
Pavenstädt H. Pals1 Haploinsufficiency Results in Proteinuria and Cyst Formation.
J Am Soc Nephrol. 2017 Jul;28(7):2093-2107. doi: 10.1681/ASN.2016040474. Epub 2017 Feb 2. PMID: 28154200; PMCID: PMC5491275.
5: Hochapfel F, Denk L, Mendl G, Schulze U, Maaßen C, Zaytseva Y, Pavenstädt H, Weide T, Rachel R, Witzgall R, Krahn MP.
Distinct functions of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes.
Cell Mol Life Sci. 2017 Dec;74(24):4573-4586. doi: 10.1007/s00018-017-2593-y. Epub 2017 Jul 17. PMID: 28717874.
6: Renschler FA, Bruekner SR, Salomon PL, Mukherjee A, Kullmann L, Schütz- Stoffregen MC, Henzler C, Pawson T, Krahn MP, Wiesner S.
Structural basis for the interaction between the cell polarity proteins Par3 and Par6.
Sci Signal. 2018 Feb 13;11(517):eaam9899. doi: 10.1126/scisignal.aam9899. PMID: 29440511.
7: Kullmann L, Krahn MP.
Controlling the master-upstream regulation of the tumor suppressor LKB1.
Oncogene. 2018 Jun;37(23):3045-3057. doi: 10.1038/s41388-018-0145-z. Epub 2018 Mar 15. PMID: 29540834.
8: Pürckhauer K, Weymouth AJ, Pfeffer K, Kullmann L, Mulvihill E, Krahn MP, Müller DJ, Giessibl FJ.
Imaging in Biologically-Relevant Environments with AFM Using Stiff qPlus Sensors.
Sci Rep. 2018 Jun 19;8(1):9330. doi: 10.1038/s41598-018-27608-6. PMID: 29921947; PMCID: PMC6008343.
9: Kullmann L, Krahn MP.
Redundant regulation of localization and protein stability of DmPar3.
Cell Mol Life Sci. 2018 Sep;75(17):3269-3282. doi: 10.1007/s00018-018-2792-1. Epub 2018 Mar 10. PMID: 29523893.
10: Hochapfel F, Denk L, Maaßen C, Zaytseva Y, Rachel R, Witzgall R, Krahn MP.
Electron microscopy of Drosophila garland cell nephrocytes: Optimal preparation, immunostaining and STEM tomography.
J Cell Biochem. 2018 Nov;119(10):8011-8021. doi: 10.1002/jcb.26702. Epub 2018 Jun 20. PMID: 29380411.
11: Schütte-Nütgen K, Edeling M, Mendl G, Krahn MP, Edemir B, Weide T, Kremerskothen J, Michgehl U, Pavenstädt H.
Getting a Notch closer to renal dysfunction: activated Notch suppresses expression of the adaptor protein Disabled-2 in tubular epithelial cells.
FASEB J. 2019 Jan;33(1):821-832. doi: 10.1096/fj.201800392RR. Epub 2018 Jul 27. PMID: 30052485.
12: Moschall R, Rass M, Rossbach O, Lehmann G, Kullmann L, Eichner N, Strauss D, Meister G, Schneuwly S, Krahn MP, Medenbach J.
Drosophila Sister-of-Sex-lethal reinforces a male-specific gene expression pattern by controlling Sex-lethal alternative splicing.
Nucleic Acids Res. 2019 Mar 18;47(5):2276-2288. doi: 10.1093/nar/gky1284. PMID: 30590805; PMCID: PMC6411925.
13: Krahn MP.
Phospholipids of the Plasma Membrane - Regulators or Consequence of Cell Polarity?
Front Cell Dev Biol. 2020 Apr 28;8:277. doi: 10.3389/fcell.2020.00277. PMID: 32411703; PMCID: PMC7198698.
14: Blazquez R, Rietkötter E, Wenske B, Wlochowitz D, Sparrer D, Vollmer E, Müller G, Seegerer J, Sun X, Dettmer K, Barrantes-Freer A, Stange L, Utpatel
K, Bleckmann A, Treiber H, Bohnenberger H, Lenz C, Schulz M, Reimelt C, Hackl C, Grade M, Büyüktas D, Siam L, Balkenhol M, Stadelmann C, Kube D,
Krahn MP, Proescholdt MA, Riemenschneider MJ, Evert M, Oefner PJ, Klein CA, Hanisch UK, Binder C, Pukrop T.
LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer.
Int J Cancer. 2020 Jun 1;146(11):3170-3183. doi: 10.1002/ijc.32742. Epub 2019 Nov 11. PMID: 31626715.
15: Bayraktar S, Nehrig J, Menis E, Karli K, Janning A, Struk T, Halbritter J, Michgehl U, Krahn MP, Schuberth CE, Pavenstädt H, Wedlich-Söldner R.
A Deregulated Stress Response Underlies Distinct INF2-Associated Disease Profiles.
J Am Soc Nephrol. 2020 Jun;31(6):1296-1313. doi: 10.1681/ASN.2019111174. PMID: 32444357; PMCID: PMC7269351.
16: Hermann A, Wu G, Nedvetsky PI, Brücher VC, Egbring C, Bonse J, Höffken V, Wennmann DO, Marks M, Krahn MP, Schöler H, Heiduschka P,
Pavenstädt H, Kremerskothen J.
The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice.
Cell Death Dis. 2021 Jan 22;12(1):117. doi: 10.1038/s41419-021-03409-0. PMID: 33483469; PMCID: PMC7822818.
17: Heiden S, Siwek R, Lotz ML, Borkowsky S, Schröter R, Nedvetsky P, Rohlmann A, Missler M, Krahn MP.
Apical-basal polarity regulators are essential for slit diaphragm assembly and endocytosis in Drosophila nephrocytes.
Cell Mol Life Sci. 2021 Apr;78(7):3657-3672. doi: 10.1007/s00018-021-03769-y. Epub 2021 Mar 2. PMID: 33651172; PMCID: PMC8038974.
18: Lüttgenau SM, Emming C, Wagner T, Harms J, Guske J, Weber K, Neugebauer U, Schröter R, Panichkina O, Pethő Z, Weber F, Schwab A, Wege AK,
Nedvetsky P, Krahn MP.
Pals1 prevents Rac1-dependent colorectal cancer cell metastasis by inhibiting Arf6.
Mol Cancer. 2021 May 4;20(1):74. doi: 10.1186/s12943-021-01354-2. PMID: 33941200; PMCID: PMC8094600.
19: Schwertner B, Lindner G, Toledo Stauner C, Klapproth E, Magnus C, Rohrhofer A, Gross S, Schuler-Thurner B, Öttl V, Feichtgruber N, Drexler K, Evert K,
Krahn MP, Berneburg M, Schmidt B, Schuster P, Haferkamp S.
Nectin-1 Expression Correlates with the Susceptibility of Malignant Melanoma to Oncolytic Herpes Simplex Virus In Vitro and In Vivo.
Cancers (Basel). 2021 Jun 19;13(12):3058. doi: 10.3390/cancers13123058. PMID: 34205379; PMCID: PMC8234279.
20: Marzano M, Herzmann S, Elsbroek L, Sanal N, Tarbashevich K, Raz E, Krahn MP, Rumpf S.
AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila.
Cell Rep. 2021 Nov 16;37(7):110024. doi: 10.1016/j.celrep.2021.110024. PMID: 34788610.
21: Dogliotti G, Kullmann L, Dhumale P, Thiele C, Panichkina O, Mendl G, Houben R, Haferkamp S, Püschel AW, Krahn MP.
Author Correction: Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.
Nat Commun. 2022 Mar 8;13(1):1283. doi: 10.1038/s41467-022-28923-3. Erratum for: Nat Commun. 2017 Jun 26;8:15747. PMID: 35260598;
PMCID: PMC8904824.
22: Maywald ML, Picciotto C, Lepa C, Bertgen L, Yousaf FS, Ricker A, Klingauf J, Krahn MP, Pavenstädt H, George B.
Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity.
Front Cell Dev Biol. 2022 Mar 18;10:790365. doi: 10.3389/fcell.2022.790365. PMID: 35372328; PMCID: PMC8972170.
23: Gass MM, Borkowsky S, Lotz ML, Siwek R, Schröter R, Nedvetsky P, Luschnig S, Rohlmann A, Missler M, Krahn MP.
PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes.
Cell Mol Life Sci. 2022 Apr 18;79(5):248. doi: 10.1007/s00018-022-04273-7. PMID: 35437696; PMCID: PMC9016003.
24: Harms J, Lüttgenau SM, Emming C, Guske J, Weber K, Wagner T, Schowe L, Nedvetsky P, Krahn MP.
Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion.
Cancer Gene Ther. 2022 Dec 9. doi: 10.1038/s41417-022-00570-2. Epub ahead of print. PMID: 36494580.
25: Krausel V, Pund L, Nüsse H, Bachir H, Ricker A, Klingauf J, Weide T, Pavenstädt H, Krahn MP, Braun DA.
The transcription factor ATF4 mediates endoplasmic reticulum stress-related podocyte injury and slit diaphragm defects.
Kidney Int. 2022 Dec 29:S0085-2538(22)01088-2. doi: 10.1016/j.kint.2022.11.024. Epub ahead of print. PMID: 36587794.
26: Schlevogt B, Schlieper V, Krader J, Schröter R, Wagner T, Weiand M, Zibert A, Schmidt HH, Bergmann C, Nedvetsky PI, Krahn MP.
A SEC61A1 variant is associated with autosomal dominant polycystic liver disease.
Liver Int. 2023 Feb;43(2):401-412. doi: 10.1111/liv.15493. Epub 2022 Dec 20. PMID: 36478640.
27: Schenk LK, Schulze U, Henke S, Weide T, Pavenstädt H.
TMEM16F Regulates Baseline Phosphatidylserine Exposure and Cell Viability in Human Embryonic Kidney Cells.
Cell Physiol Biochem. 2016;38(6):2452-63. doi: 10.1159/000445596. Epub 2016 Jun 13. PMID: 27287741.
28: Djuric I, Siebrasse JP, Schulze U, Granado D, Schlüter MA, Kubitscheck U, Pavenstädt H, Weide T.
The C-terminal domain controls the mobility of Crumbs 3 isoforms.
Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1208-17. doi: 10.1016/j.bbamcr.2016.03.008. Epub 2016 Mar 11. PMID: 26975581.
29: Siebrasse JP, Djuric I, Schulze U, Schlüter MA, Pavenstädt H, Weide T, Kubitscheck U.
Trajectories and single-particle tracking data of intracellular vesicles loaded with either SNAP-Crb3A or SNAP-Crb3B.
Data Brief. 2016 Apr 29;7:1665-9. doi: 10.1016/j.dib.2016.04.058. PMID: 27222870; PMCID: PMC4872679.
30: Schulze U, Vollenbröker B, Kühnl A, Granado D, Bayraktar S, Rescher U, Pavenstädt H, Weide T.
Cellular vacuolization caused by overexpression of the PIKfyve-binding deficient Vac14<sup>L156R</sup> is rescued by starvation and
inhibition of vacuolar-ATPase.
Biochim Biophys Acta Mol Cell Res. 2017 May;1864(5):749-759. doi: 10.1016/j.bbamcr.2017.02.012. Epub 2017 Feb 16. PMID: 28216340.
31: Granado D, Müller D, Krausel V, Kruzel-Davila E, Schuberth C, Eschborn M, Wedlich-Söldner R, Skorecki K, Pavenstädt H, Michgehl U, Weide T.
Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion.
J Am Soc Nephrol. 2017 Nov;28(11):3227-3238. doi: 10.1681/ASN.2016111220. Epub 2017 Jul 10. PMID: 28696248; PMCID: PMC5661279.
32: Schenk LK, Möller-Kerutt A, Klosowski R, Wolters D, Schaffner-Reckinger E, Weide T, Pavenstädt H, Vollenbröker B.
Angiotensin II regulates phosphorylation of actin-associated proteins in human podocytes.
FASEB J. 2017 Nov;31(11):5019-5035. doi: 10.1096/fj.201700142R. Epub 2017 Aug 2. PMID: 28768720.
33: Gromnitza S, Lepa C, Weide T, Schwab A, Pavenstädt H, George B.
Tropomyosin- related kinase C (TrkC) enhances podocyte migration by ERK-mediated WAVE2
activation. FASEB J. 2018 Mar;32(3):1665-1676. doi: 10.1096/fj.201700703R. Epub 2018 Jan 3. PMID: 29162704.
34: Hermann A, Wennmann DO, Gromnitza S, Edeling M, Van Marck V, Sudol M, Schaefer L, Duning K, Weide T, Pavenstädt H, Kremerskothen J.
WW and C2 domain- containing proteins regulate hepatic cell differentiation and tumorigenesis through the hippo signaling pathway.
Hepatology. 2018 Apr;67(4):1546-1559. doi: 10.1002/hep.29647. Epub 2018 Feb 18. PMID: 29116649.
35: Bonse J, Wennmann DO, Kremerskothen J, Weide T, Michgehl U, Pavenstädt H, Vollenbröker B.
Nuclear YAP localization as a key regulator of podocyte function.
Cell Death Dis. 2018 Aug 28;9(9):850. doi: 10.1038/s41419-018-0878-1. PMID: 30154411; PMCID: PMC6113334.
36: Michgehl U, Skryabin BV, Bayraktar S, Vollenbröker B, Ciarimboli G, Heitplatz B, Van Marck V, Gröne HJ, Pavenstädt H, Weide T.
Nephron-specific knockin of the PIKfyve-binding-deficient Vac14<sup>L156R</sup> mutant results in
albuminuria and mesangial expansion. Am J Physiol Renal Physiol. 2018 Nov
1;315(5):F1307-F1319. doi: 10.1152/ajprenal.00191.2018. Epub 2018 Aug 1. PMID: 30066585.
37: Dlugos CP, Picciotto C, Lepa C, Krakow M, Stöber A, Eddy ML, Weide T, Jeibmann A, P Krahn M, Van Marck V, Klingauf J, Ricker A, Wedlich-Söldner R,
Pavenstädt H, Klämbt C, George B.
Nephrin Signaling Results in Integrin <i>β</i>1 Activation.
J Am Soc Nephrol. 2019 Jun;30(6):1006-1019. doi: 10.1681/ASN.2018040362. Epub 2019 May 16. PMID: 31097607; PMCID: PMC6551783.
38: Lepa C, Möller-Kerutt A, Stölting M, Picciotto C, Eddy ML, Butt E, Kerjaschki D, Korb-Pap A, Vollenbröker B, Weide T, George B, Kremerskothen J,
Pavenstädt H.
LIM and SH3 protein 1 (LASP-1): A novel link between the slit membrane and actin cytoskeleton dynamics in podocytes.
FASEB J. 2020 Apr;34(4):5453-5464. doi: 10.1096/fj.201901443R. Epub 2020 Feb 21. PMID: 32086849.
39: Lepa C, Hoppe S, Stöber A, Skryabin BV, Sievers LK, Heitplatz B, Ciarimboli G, Neugebauer U, Lindenmeyer MT, Cohen CD, Drexler HCA, Boor P,
Weide T, Pavenstädt H, George B.
TrkC Is Essential for Nephron Function and Trans- Activates Igf1R Signaling.
J Am Soc Nephrol. 2021 Feb;32(2):357-374. doi: 10.1681/ASN.2020040424. Epub 2020 Dec 30. PMID: 33380522; PMCID: PMC8054883.
40: Möller-Kerutt A, Rodriguez-Gatica JE, Wacker K, Bhatia R, Siebrasse JP, Boon N, Van Marck V, Boor P, Kubitscheck U, Wijnholds J, Pavenstädt H,
Weide T.
Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier.
J Am Soc Nephrol. 2021 May 3;32(5):1053-1070. doi: 10.1681/ASN.2020040501. Epub 2021 Mar 9. PMID: 33687977; PMCID: PMC8259666.
41: Jehn U, Bayraktar S, Pollmann S, Van Marck V, Weide T, Pavenstädt H, Brand E, Lenders M.
α-Galactosidase a Deficiency in Fabry Disease Leads to Extensive Dysregulated Cellular Signaling Pathways in Human Podocytes.
Int J Mol Sci. 2021 Oct 20;22(21):11339. doi: 10.3390/ijms222111339. PMID: 34768768; PMCID: PMC8583658.
42: Müller D, Schmitz J, Fischer K, Granado D, Groh AC, Krausel V, Lüttgenau SM, Amelung TM, Pavenstädt H, Weide T.
Evolution of Renal-Disease Factor APOL1 Results in Cis and Trans Orientations at the Endoplasmic Reticulum That Both Show Cytotoxic Effects.
Mol Biol Evol. 2021 Oct 27;38(11):4962-4976. doi: 10.1093/molbev/msab220. PMID: 34323996; PMCID: PMC8557400.
43: Berghaus C, Groh AC, Breljak D, Ciarimboli G, Sabolić I, Pavenstädt H, Weide T.
Impact of Pals1 on Expression and Localization of Transporters Belonging to the Solute Carrier Family.
Front Mol Biosci. 2022 Feb 16;9:792829. doi: 10.3389/fmolb.2022.792829. PMID: 35252349; PMCID: PMC8888964.
44: Möller-Kerutt A, Schönhoff B, Rellmann Y, George B, Braun DA, Pavenstädt H, Weide T.
Loss of surface transport is a main cellular pathomechanism of CRB2 variants causing podocytopathies.
Life Sci Alliance. 2022 Dec 22;6(3):e202201649. doi: 10.26508/lsa.202201649. PMID: 36549870; PMCID: PMC9780758.
AG Lecaudey
1: Nakajima H, Yamamoto K, Agarwala S, Terai K, Fukui H, Fukuhara S, Ando K, Miyazaki T, Yokota Y, Schmelzer E, Belting HG, Affolter M, Lecaudey V,
Mochizuki N.
Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance.
Dev Cell. 2017 Mar 27;40(6):523-536.e6. doi: 10.1016/j.devcel.2017.02.019. PMID: 28350986.
2: Eckerle S, Ringler M, Lecaudey V, Nitschke R, Driever W.
Progesterone modulates microtubule dynamics and epiboly progression during zebrafish gastrulation.
Dev Biol. 2018 Feb 15;434(2):249-266. doi: 10.1016/j.ydbio.2017.12.016. Epub 2017 Dec 26. PMID: 29287832.
3: Yakulov TA, Todkar AP, Slanchev K, Wiegel J, Bona A, Groß M, Scholz A, Hess I, Wurditsch A, Grahammer F, Huber TB, Lecaudey V, Bork T, Hochrein J,
Boerries M, Leenders J, de Tullio P, Jouret F, Kramer-Zucker A, Walz G.
CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury.
Nat Commun. 2018 Sep 10;9(1):3660. doi: 10.1038/s41467-018-06094-4. PMID: 30202007; PMCID: PMC6131511.
4: Dingare C, Niedzwetzki A, Klemmt PA, Godbersen S, Fuentes R, Mullins MC, Lecaudey V.
The Hippo pathway effector Taz is required for cell morphogenesis and fertilization in zebrafish.
Development. 2018 Nov 22;145(22):dev167023. doi: 10.1242/dev.167023. PMID: 30327325; PMCID: PMC6262795.
5: Voltes A, Hevia CF, Engel-Pizcueta C, Dingare C, Calzolari S, Terriente J, Norden C, Lecaudey V, Pujades C.
Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation.
Development. 2019 Jul 22;146(14):dev176735. doi: 10.1242/dev.176735. PMID: 31273051.
6: Norden C, Lecaudey V.
Collective cell migration: general themes and newparadigms.
Curr Opin Genet Dev. 2019 Aug;57:54-60. doi: 10.1016/j.gde.2019.06.013. Epub 2019 Aug 18. PMID: 31430686.
7: Bornhorst D, Xia P, Nakajima H, Dingare C, Herzog W, Lecaudey V, Mochizuki N, Heisenberg CP, Yelon D, Abdelilah-Seyfried S.
Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions.
Nat Commun. 2019 Sep 11;10(1):4113. doi: 10.1038/s41467-019-12068-x. PMID: 31511517; PMCID: PMC6739419.
8: Kleinhans DS, Lecaudey V.
Standardized mounting method of (zebrafish) embryos using a 3D-printed stamp for high-content, semi-automated confocal imaging.
BMC Biotechnol. 2019 Oct 22;19(1):68. doi: 10.1186/s12896-019-0558-y. PMID: 31640669; PMCID: PMC6805687.
9: Bode E, Heinrich AK, Hirschmann M, Abebew D, Shi YN, Vo TD, Wesche F, Shi YM, Grün P, Simonyi S, Keller N, Engel Y, Wenski S, Bennet R, Beyer S,
Bischoff I, Buaya A, Brandt S, Cakmak I, Çimen H, Eckstein S, Frank D, Fürst R, Gand M, Geisslinger G, Hazir S, Henke M, Heermann R, Lecaudey V, Schäfer
W, Schiffmann S, Schüffler A, Schwenk R, Skaljac M, Thines E, Thines M, Ulshöfer T, Vilcinskas A, Wichelhaus TA, Bode HB.
Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing.
Angew Chem Int Ed Engl. 2019 Dec 19;58(52):18957-18963. doi: 10.1002/anie.201910563. Epub 2019 Dec 12. PMID: 31693786;
PMCID: PMC6972681.
10: Peralta M, Ortiz Lopez L, Jerabkova K, Lucchesi T, Vitre B, Han D, Guillemot L, Dingare C, Sumara I, Mercader N, Lecaudey V, Delaval B, Meilhac SM,
Vermot J.
Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis.
Cell Rep. 2020 Jul 21;32(3):107932. doi: 10.1016/j.celrep.2020.107932. PMID: 32698004.
11: Aguillon R, Madelaine R, Aguirrebengoa M, Guturu H, Link S, Dufourcq P, Lecaudey V, Bejerano G, Blader P, Batut J.
Morphogenesis is transcriptionally coupled to neurogenesis during peripheral olfactory organ development.
Development. 2020 Dec 21;147(24):dev192971. doi: 10.1242/dev.192971. PMID: 33144399.
12: Dingare C, Klemmt PA, Niedzwetzki A, Lecaudey V.
Labeling the Micropylar Cell in Zebrafish Whole-Mount and Cryo-sectioned Follicles.
Methods Mol Biol. 2021;2218:169-183. doi: 10.1007/978-1-0716-0970-5_14. PMID: 33606231.
AG Leube
1: Kant S, Krusche CA, Gaertner A, Milting H, Leube RE.
Loss of plakoglobin immunoreactivity in intercalated discs in arrhythmogenic right ventricular cardiomyopathy: protein mislocalization versus epitope
masking.
Cardiovasc Res. 2016 Feb 1;109(2):260-71. doi: 10.1093/cvr/cvv270. Epub 2015 Dec 16. PMID: 26676851.
2: Moch M, Windoffer R, Schwarz N, Pohl R, Omenzetter A, Schnakenberg U, Herb F, Chaisaowong K, Merhof D, Ramms L, Fabris G, Hoffmann B,
Merkel R, Leube RE.
Effects of Plectin Depletion on Keratin Network Dynamics and Organization.
PLoS One. 2016 Mar 23;11(3):e0149106. doi: 10.1371/journal.pone.0149106. PMID: 27007410; PMCID: PMC4805305.
3: Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller
S, Binder H, Löffler-Wirth H, Seibel P, Magin TM.
Correction: A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.
J Cell Biol. 2016 Mar 28;212(7):877. doi: 10.1083/jcb.20140414703042016c. Epub 2016 Mar 21. Erratum for: J Cell Biol. 2015 Dec 7;211(5):1057-75.
PMID: 27002167; PMCID: PMC4810296.
4: Coch RA, Leube RE.
Intermediate Filaments and Polarization in the Intestinal Epithelium.
Cells. 2016 Jul 15;5(3):32. doi: 10.3390/cells5030032. PMID: 27429003; PMCID: PMC5040974.
5: Geisler F, Gerhardus H, Carberry K, Davis W, Jorgensen E, Richardson C, Bossinger O, Leube RE.
A novel function for the MAP kinase SMA-5 in intestinal tube stability.
Mol Biol Cell. 2016 Dec 1;27(24):3855-3868. doi: 10.1091/mbc.E16-02-0099. Epub 2016 Oct 12. PMID: 27733627; PMCID: PMC5170608.
6: Gerçek M, Gerçek M, Kant S, Simsekyilmaz S, Kassner A, Milting H, Liehn EA, Leube RE, Krusche CA.
Cardiomyocyte Hypertrophy in Arrhythmogenic Cardiomyopathy.
Am J Pathol. 2017 Apr;187(4):752-766. doi: 10.1016/j.ajpath.2016.12.018. Epub 2017 Feb 7. PMID: 28183531.
7: Leube RE, Moch M, Windoffer R.
Intracellular Motility of Intermediate Filaments.
Cold Spring Harb Perspect Biol. 2017 Jun 1;9(6):a021980. doi: 10.1101/cshperspect.a021980. PMID: 28572456; PMCID: PMC5453390.
8: Quinlan RA, Schwarz N, Windoffer R, Richardson C, Hawkins T, Broussard JA, Green KJ, Leube RE.
A rim-and-spoke hypothesis to explain the biomechanical roles for cytoplasmic intermediate filament networks.
J Cell Sci. 2017 Oct 15;130(20):3437-3445. doi: 10.1242/jcs.202168. PMID: 29032358; PMCID: PMC6518161.
9: Sawant M, Schwarz N, Windoffer R, Magin TM, Krieger J, Mücke N, Obara B, Jankowski V, Jankowski J, Wally V, Lettner T, Leube RE.
Threonine 150 Phosphorylation of Keratin 5 Is Linked to Epidermolysis Bullosa Simplex and Regulates Filament Assembly and Cell Viability.
J Invest Dermatol. 2018 Mar;138(3):627-636. doi: 10.1016/j.jid.2017.10.011. Epub 2017 Dec 6. PMID: 29080682.
10: Buck VU, Hodecker M, Eisner S, Leube RE, Krusche CA, Classen-Linke I.
Ultrastructural changes in endometrial desmosomes of desmoglein 2 mutant mice.
Cell Tissue Res. 2018 Nov;374(2):317-327. doi: 10.1007/s00441-018-2869-z. Epub 2018 Jun 25. PMID: 29938327.
11: Gross A, Pack LAP, Schacht GM, Kant S, Ungewiss H, Meir M, Schlegel N, Preisinger C, Boor P, Guldiken N, Krusche CA, Sellge G, Trautwein C,
Waschke J, Heuser A, Leube RE, Strnad P.
Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury.
Mucosal Immunol. 2018 Nov;11(6):1630-1639. doi: 10.1038/s41385-018-0062-z. Epub 2018 Aug 16. PMID: 30115995.
12: Geisler F, Coch RA, Richardson C, Goldberg M, Denecke B, Bossinger O, Leube RE.
The intestinal intermediate filament network responds to and protects against microbial insults and toxins.
Development. 2019 Jan 23;146(2):dev169482. doi: 10.1242/dev.169482. PMID: 30630824.
13: Kant S, Freytag B, Herzog A, Reich A, Merkel R, Hoffmann B, Krusche CA, Leube RE.
Desmoglein 2 mutation provokes skeletal muscle actin expression and accumulation at intercalated discs in murine hearts.
J Cell Sci. 2019 Feb 18;132(5):jcs199612. doi: 10.1242/jcs.199612. PMID: 30659114.
14: Pora A, Yoon S, Windoffer R, Leube RE.
Hemidesmosomes and Focal Adhesions Treadmill as Separate but Linked Entities during Keratinocyte Migration.
J Invest Dermatol. 2019 Sep;139(9):1876-1888.e4. doi: 10.1016/j.jid.2019.03.1139. Epub 2019 Apr 2. PMID: 30951704.
15: Yoon S, Leube RE.
Keratin intermediate filaments: intermediaries of epithelial cell migration.
Essays Biochem. 2019 Oct 31;63(5):521-533. doi: 10.1042/EBC20190017. PMID: 31652439.
16: Moch M, Schwarz N, Windoffer R, Leube RE.
The keratin-desmosome scaffold: pivotal role of desmosomes for keratin network morphogenesis.
Cell Mol Life Sci. 2020 Feb;77(3):543-558. doi: 10.1007/s00018-019-03198-y. Epub 2019 Jun 26. PMID: 31243490; PMCID: PMC7010626.
17: Geisler F, Coch RA, Richardson C, Goldberg M, Bevilacqua C, Prevedel R, Leube RE.
Intestinal intermediate filament polypeptides in C. elegans: Common and isotype-specific contributions to intestinal ultrastructure and function.
Sci Rep. 2020 Feb 21;10(1):3142. doi: 10.1038/s41598-020-59791-w. PMID: 32081918; PMCID: PMC7035338.
18: Leube RE, Schwarz N.
Current mysteries of pachyonychia congenita.
Br J Dermatol. 2020 Mar;182(3):525-526. doi: 10.1111/bjd.18688. Epub 2019 Dec 8. PMID: 31814103.
19: Pora A, Yoon S, Dreissen G, Hoffmann B, Merkel R, Windoffer R, Leube RE.
Regulation of keratin network dynamics by the mechanical properties of the environment in migrating cells.
Sci Rep. 2020 Mar 12;10(1):4574. doi: 10.1038/s41598-020-61242-5. PMID: 32165652; PMCID: PMC7067805.
20: Schinner C, Erber BM, Yeruva S, Schlipp A, Rötzer V, Kempf E, Kant S, Leube RE, Mueller TD, Waschke J.
Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy.
JCI Insight. 2020 May 7;5(9):e130141. doi: 10.1172/jci.insight.130141. PMID: 32376797; PMCID: PMC7253015.
21: Lubos N, van der Gaag S, Gerçek M, Kant S, Leube RE, Krusche CA.
Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy.
Basic Res Cardiol. 2020 Jun 12;115(4):42. doi: 10.1007/s00395-020-0803-5. PMID: 32529556; PMCID: PMC7289786.
22: Haimov E, Windoffer R, Leube RE, Urbakh M, Kozlov MM.
Model for Bundling of Keratin Intermediate Filaments.
Biophys J. 2020 Jul 7;119(1):65-74. doi: 10.1016/j.bpj.2020.05.024. Epub 2020 Jun 2. PMID: 32533940; PMCID: PMC7335914.
23: Coch RA, Geisler F, Annibal A, Antebi A, Leube RE.
Identification of a Novel Link between the Intermediate Filament Organizer IFO-1 and Cholesterol Metabolism in the Caenorhabditis
elegans Intestine.
Int J Mol Sci. 2020 Nov 3;21(21):8219. doi: 10.3390/ijms21218219. PMID: 33153048; PMCID: PMC7672635.
24: Bornes L, Windoffer R, Leube RE, Morgner J, van Rheenen J.
Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytes.
Life Sci Alliance. 2020 Nov 30;4(1):e202000765. doi: 10.26508/lsa.202000765. PMID: 33257474; PMCID: PMC7723264.
25: Moch M, Leube RE.
Hemidesmosome-Related Keratin Filament Bundling and Nucleation.
Int J Mol Sci. 2021 Feb 21;22(4):2130. doi: 10.3390/ijms22042130. PMID: 33669958; PMCID: PMC7924876.
26: Remmelzwaal S, Geisler F, Stucchi R, van der Horst S, Pasolli M, Kroll JR, Jarosinska OD, Akhmanova A, Richardson CA, Altelaar M, Leube RE,
Ramalho JJ, Boxem M.
BBLN-1 is essential for intermediate filament organization and apical membrane morphology.
Curr Biol. 2021 Jun 7;31(11):2334-2346.e9. doi: 10.1016/j.cub.2021.03.069. Epub 2021 Apr 14. PMID: 33857431.
27: Sternberg AK, Buck VU, Classen-Linke I, Leube RE.
How Mechanical Forces Change the Human Endometrium during the Menstrual Cycle in Preparation for Embryo Implantation. Cells.
2021 Aug 6;10(8):2008. doi: 10.3390/cells10082008. PMID: 34440776; PMCID: PMC8391722.
28: Moazzen H, Venger K, Kant S, Leube RE, Krusche CA.
Desmoglein 2 regulates cardiogenesis by restricting hematopoiesis in the developing murine heart.
Sci Rep. 2021 Nov 4;11(1):21687. doi: 10.1038/s41598-021-00996-y. PMID: 34737300; PMCID: PMC8569146.
29: Pitsch M, Kant S, Mytzka C, Leube RE, Krusche CA.
Autophagy and Endoplasmic Reticulum Stress during Onset and Progression of Arrhythmogenic Cardiomyopathy.
Cells. 2021 Dec 29;11(1):96. doi: 10.3390/cells11010096. PMID: 35011658; PMCID: PMC8750195.
30: Gross A, Zhou B, Bewersdorf L, Schwarz N, Schacht GM, Boor P, Hoeft K, Hoffmann B, Fuchs E, Kramann R, Merkel R, Leube RE, Strnad P.
Desmoplakin Maintains Transcellular Keratin Scaffolding and Protects From Intestinal Injury.
Cell Mol Gastroenterol Hepatol. 2022;13(4):1181-1200. doi: 10.1016/j.jcmgh.2021.12.009. Epub 2021 Dec 17. PMID: 34929421;
PMCID: PMC8873596.
31: Windoffer R, Schwarz N, Yoon S, Piskova T, Scholkemper M, Stegmaier J, Bönsch A, Di Russo J, Leube RE.
Quantitative mapping of keratin networks in 3D.
Elife. 2022 Feb 18;11:e75894. doi: 10.7554/eLife.75894. PMID: 35179484; PMCID: PMC8979588.
32: Nahaboo W, Eski SE, Despin-Guitard E, Vermeersch M, Versaevel M, Saykali B, Monteyne D, Gabriele S, Magin TM, Schwarz N, Leube RE, Zwijsen A,
Perez-Morga D, Singh SP, Migeotte I.
Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo.
EMBO J. 2022 Apr 4;41(7):e108747. doi: 10.15252/embj.2021108747. Epub 2022 Mar 10. PMID: 35266581; PMCID: PMC8982622.
33: Yoon S, Windoffer R, Kozyrina AN, Piskova T, Di Russo J, Leube RE.
Combining Image Restoration and Traction Force Microscopy to Study Extracellular Matrix- Dependent Keratin Filament Network Plasticity.
Front Cell Dev Biol. 2022 May 11;10:901038. doi: 10.3389/fcell.2022.901038. PMID: 35646906; PMCID: PMC9131083.
34: Ratajczyk S, Drexler C, Windoffer R, Leube RE, Fuchs P.
A Ca<sup>2+</sup>-Mediated Switch of Epiplakin from a Diffuse to Keratin-Bound State Affects Keratin Dynamics.
Cells. 2022 Sep 30;11(19):3077. doi: 10.3390/cells11193077. PMID: 36231039; PMCID: PMC9563781.
35: Moch M, Schieren J, Leube RE.
Cortical tension regulates desmosomal morphogenesis.
Front Cell Dev Biol. 2022 Oct 4;10:946190. doi: 10.3389/fcell.2022.946190. PMID: 36268507; PMCID: PMC9577410.
36: Despin-Guitard E, Quenec'Hdu R, Nahaboo W, Schwarz N, Leube RE, Chazaud C, Migeotte I.
Regionally specific levels and patterns of keratin 8 expression in the mouse embryo visceral endoderm emerge upon anterior-posterior axis
determination.
Front Cell Dev Biol. 2022 Dec 1;10:1037041. doi: 10.3389/fcell.2022.1037041. PMID: 36531946; PMCID: PMC9751397.
37: Spindler V, Gerull B, Green KJ, Kowalczyk AP, Leube R, Marian AJ, Milting H, Müller EJ, Niessen C, Payne AS, Schlegel N, Schmidt E, Strnad P, Tikkanen
R, Vielmuth F, Waschke J.
Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting.
J Cell Sci. 2023 Jan 1;136(1):jcs260832. doi: 10.1242/jcs.260832. Epub 2023 Jan 3. PMID: 36594662.
AG Magin
1: Hering L, Bouameur JE, Reichelt J, Magin TM, Mayer G.
Novel origin of lamin- derived cytoplasmic intermediate filaments in tardigrades.
Elife. 2016 Feb 3;5:e11117. doi: 10.7554/eLife.11117. PMID: 26840051; PMCID: PMC4829535.
2: Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller
S, Binder H, Löffler-Wirth H, Seibel P, Magin TM.
Correction: A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.
J Cell Biol. 2016 Mar 28;212(7):877. doi: 10.1083/jcb.20140414703042016c. Epub 2016 Mar 21. Erratum for: J Cell Biol. 2015 Dec 7;211(5):1057-75.
PMID: 27002167; PMCID: PMC4810296.
3: Wallrath LL, Bohnekamp J, Magin TM.
Cross talk between the cytoplasm and nucleus during development and disease.
Curr Opin Genet Dev. 2016 Apr;37:129-136. doi: 10.1016/j.gde.2016.03.007. Epub 2016 Apr 23. PMID: 27110666.
4: Rietscher K, Wolf A, Hause G, Rother A, Keil R, Magin TM, Glass M, Niessen CM, Hatzfeld M.
Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo.
J Invest Dermatol. 2016 Jul;136(7):1471-1478. doi: 10.1016/j.jid.2016.03.021. Epub 2016 Mar 28. PMID: 27033150.
5: Kumar V, Behr M, Kiritsi D, Scheffschick A, Grahnert A, Homberg M, Schwieger- Briel A, Jakob T, Bruckner-Tuderman L, Magin TM.
Keratin-dependent thymic stromal lymphopoietin expression suggests a link between skin blistering and atopic disease.
J Allergy Clin Immunol. 2016 Nov;138(5):1461-1464.e6. doi: 10.1016/j.jaci.2016.04.046. Epub 2016 Jun 15. PMID: 27527262.
6: Bouameur JE, Magin TM.
Lessons from Animal Models of Cytoplasmic Intermediate Filament Proteins.
Subcell Biochem. 2017;82:171-230. doi: 10.1007/978-3-319-49674-0_7. PMID: 28101863.
7: Hatzfeld M, Keil R, Magin TM.
Desmosomes and Intermediate Filaments: Their Consequences for Tissue Mechanics.
Cold Spring Harb Perspect Biol. 2017 Jun 1;9(6):a029157. doi: 10.1101/cshperspect.a029157. PMID: 28096266; PMCID: PMC5453391.
8: Vielmuth F, Wanuske MT, Radeva MY, Hiermaier M, Kugelmann D, Walter E, Buechau F, Magin TM, Waschke J, Spindler V.
Keratins Regulate the Adhesive Properties of Desmosomal Cadherins through Signaling.
J Invest Dermatol. 2018 Jan;138(1):121-131. doi: 10.1016/j.jid.2017.08.033. Epub 2017 Sep 9. PMID: 28899688.
9: Sawant M, Schwarz N, Windoffer R, Magin TM, Krieger J, Mücke N, Obara B, Jankowski V, Jankowski J, Wally V, Lettner T, Leube RE.
Threonine 150 Phosphorylation of Keratin 5 Is Linked to Epidermolysis Bullosa Simplex and Regulates Filament Assembly and Cell Viability.
J Invest Dermatol. 2018 Mar;138(3):627-636. doi: 10.1016/j.jid.2017.10.011. Epub 2017 Dec 6. PMID: 29080682.
10: Vielmuth F, Walter E, Fuchs M, Radeva MY, Buechau F, Magin TM, Spindler V, Waschke J.
Keratins Regulate p38MAPK-Dependent Desmoglein Binding Properties in Pemphigus.
Front Immunol. 2018 Mar 19;9:528. doi: 10.3389/fimmu.2018.00528. PMID: 29616033; PMCID: PMC5868517.
11: Zarkoob H, Chinnathambi S, Halberg SA, Selby JC, Magin TM, Sander EA.
Mouse Keratinocytes Without Keratin Intermediate Filaments Demonstrate Substrate Stiffness Dependent Behaviors.
Cell Mol Bioeng. 2018 May 2;11(3):163-174. doi: 10.1007/s12195-018-0526-y. PMID: 31719883; PMCID: PMC6816603.
12: Büchau F, Munz C, Has C, Lehmann R, Magin TM.
KLHL16 Degrades Epidermal Keratins.
J Invest Dermatol. 2018 Aug;138(8):1871-1873. doi: 10.1016/j.jid.2018.02.017. Epub 2018 Feb 23. PMID: 29481904.
13: Ahrens D, Rubner W, Springer R, Hampe N, Gehlen J, Magin TM, Hoffmann B, Merkel R.
A Combined AFM and Lateral Stretch Device Enables Microindentation Analyses of Living Cells at High Strains.
Methods Protoc. 2019 May 24;2(2):43. doi: 10.3390/mps2020043. PMID: 31164622; PMCID: PMC6632168.
14: Spörrer M, Prochnicki A, Tölle RC, Nyström A, Esser PR, Homberg M, Athanasiou I, Zingkou E, Schilling A, Gerum R, Thievessen I, Winter L, Bruckner-
Tuderman L, Fabry B, Magin TM, Dengjel J, Schröder R, Kiritsi D.
Treatment of keratinocytes with 4-phenylbutyrate in epidermolysis bullosa: Lessons for therapies in keratin disorders.
EBioMedicine. 2019 Jun;44:502-515. doi: 10.1016/j.ebiom.2019.04.062. Epub 2019 May 9. PMID: 31078522; PMCID: PMC6603805.
15: Hatzfeld M, Magin TM.
Cross-Talk between Hemidesmosomes and Focal Adhesions: A Primer for Wound Healing, Blistering Skin Disease, and Skin Aging.
J Invest Dermatol. 2019 Sep;139(9):1854-1856. doi: 10.1016/j.jid.2019.04.010. PMID: 31445572.
16: Scheffschick A, Kiritsi D, Magin TM.
Keratin defects trigger the itch- inducing cytokine thymic stromal lymphopoietin through amphiregulin-epidermal growth factor receptor signaling.
J Allergy Clin Immunol. 2019 Dec;144(6):1719-1722.e3. doi: 10.1016/j.jaci.2019.07.041. Epub 2019 Aug 16. PMID: 31425777.
17: Vetter A, Jahn K, Bouameur JE, Kiritsi D, Magin TM.
Epidermolysis Bullosa Simplex Keratinocytes Show Disturbed Mitochondrial Positioning and Activity.
J Invest Dermatol. 2020 Jul;140(7):1438-1442.e5. doi: 10.1016/j.jid.2019.10.023. Epub 2020 Jan 18. PMID: 31958432.
18: Fujiwara S, Deguchi S, Magin TM.
Disease-associated keratin mutations reduce traction forces and compromise adhesion and collective migration.
J Cell Sci. 2020 Jul 29;133(14):jcs243956. doi: 10.1242/jcs.243956. PMID: 32616561.
19: Cogné B, Bouameur JE, Hayot G, Latypova X, Pattabiraman S, Caillaud A, Si- Tayeb K, Besnard T, Küry S, Chariau C, Gaignerie A, David L, Bordure P,
Kaganovich D, Bézieau S, Golzio C, Magin TM, Isidor B.
A dominant vimentin variant causes a rare syndrome with premature aging.
Eur J Hum Genet. 2020 Sep;28(9):1218-1230. doi: 10.1038/s41431-020-0583-2. Epub 2020 Feb 17. PMID: 32066935; PMCID: PMC7609319.
20: Bardhan A, Bruckner-Tuderman L, Chapple ILC, Fine JD, Harper N, Has C, Magin TM, Marinkovich MP, Marshall JF, McGrath JA, Mellerio JE, Polson R,
Heagerty AH.
Epidermolysis bullosa.
Nat Rev Dis Primers. 2020 Sep 24;6(1):78. doi: 10.1038/s41572-020-0210-0. PMID: 32973163.
21: Karsch S, Büchau F, Magin TM, Janshoff A.
An intact keratin network is crucial for mechanical integrity and barrier function in keratinocyte cell sheets.
Cell Mol Life Sci. 2020 Nov;77(21):4397-4411. doi: 10.1007/s00018-019-03424-7. Epub 2020 Jan 7. PMID: 31912195.
22: Weber MS, Eibauer M, Sivagurunathan S, Magin TM, Goldman RD, Medalia O.
Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo- electron microscopy.
Elife. 2021 Jul 29;10:e70307. doi: 10.7554/eLife.70307. PMID: 34323216; PMCID: PMC8360650.
23: Magin TM, Hatzfeld M.
Messages from Mutant Desmosomes.
J Invest Dermatol. 2022 Feb;142(2):272-274. doi: 10.1016/j.jid.2021.08.389. Epub 2021 Nov 17. PMID: 34799122.
24: Nahaboo W, Eski SE, Despin-Guitard E, Vermeersch M, Versaevel M, Saykali B, Monteyne D, Gabriele S, Magin TM, Schwarz N, Leube RE, Zwijsen A,
Perez-Morga D, Singh SP, Migeotte I.
Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo.
EMBO J. 2022 Apr 4;41(7):e108747. doi: 10.15252/embj.2021108747. Epub 2022 Mar 10. PMID: 35266581; PMCID: PMC8982622.
25: Büchau F, Vielmuth F, Waschke J, Magin TM.
Bidirectional regulation of desmosome hyperadhesion by keratin isotypes and desmosomal components.
Cell Mol Life Sci. 2022 Apr 5;79(5):223. doi: 10.1007/s00018-022-04244-y. PMID: 35380280; PMCID: PMC8983532.
26: Vetter A, Beier LS, Bouameur JE, Magin TM.
Keratins Modulate Cellular Reduction‒Oxidation Homeostasis and Mitochondrial Dynamics.
J Invest Dermatol. 2022 Aug;142(8):2264-2267.e6. doi: 10.1016/j.jid.2021.12.025. Epub 2021 Dec 31. PMID: 34974054.
27: Winkler R, Quaas M, Glasmacher S, Wolfrum U, Thalheim T, Galle J, Krohn K, Magin TM, Aust G.
The Adhesion G-Protein-Coupled Receptor GPR115/<i>ADGRF4</i> Regulates Epidermal Differentiation and Associates with Cytoskeletal KRT1.
Cells. 2022 Oct 7;11(19):3151. doi: 10.3390/cells11193151. PMID: 36231117; PMCID: PMC9563031.
28: Rietscher K, Jahnke HG, Rübsam M, Lin EW, Has C, Omary MB, Niessen CM, Magin TM.
Kinase Inhibition by PKC412 Prevents Epithelial Sheet Damage in Autosomal Dominant Epidermolysis Bullosa Simplex through Keratin and Cell Contact
Stabilization.
J Invest Dermatol. 2022 Dec;142(12):3282-3293. doi: 10.1016/j.jid.2022.05.1088. Epub 2022 Jun 9. PMID: 35691363.
AG Matis
1: Saha T, Rathmann I, Viplav A, Panzade S, Begemann I, Rasch C, Klingauf J, Matis M, Galic M.
Automated analysis of filopodial length and spatially resolved protein concentration via adaptive shape tracking.
Mol Biol Cell. 2016 Nov 7;27(22):3616-3626. doi: 10.1091/mbc.E16-06-0406. Epub 2016 Aug 17. PMID: 27535428; PMCID: PMC5221593.
2: Ebnet K, Kummer D, Steinbacher T, Singh A, Nakayama M, Matis M.
Regulation of cell polarity by cell adhesion receptors.
Semin Cell Dev Biol. 2018 Sep;81:2-12. doi: 10.1016/j.semcdb.2017.07.032. Epub 2017 Jul 22. PMID: 28739340.
3: Singh A, Saha T, Begemann I, Ricker A, Nüsse H, Thorn-Seshold O, Klingauf J, Galic M, Matis M.
Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis.
Nat Cell Biol. 2018 Oct;20(10):1126-1133. doi: 10.1038/s41556-018-0193-1. Epub 2018 Sep 10. PMID: 30202051.
4: Matis M.
The Mechanical Role of Microtubules in Tissue Remodeling. Bioessays.
2020 May;42(5):e1900244. doi: 10.1002/bies.201900244. Epub 2020 Apr 6. PMID: 32249455.
5: Gross-Thebing S, Truszkowski L, Tenbrinck D, Sánchez-Iranzo H, Camelo C, Westerich KJ, Singh A, Maier P, Prengel J, Lange P, Hüwel J, Gaede F, Sasse R,
Vos BE, Betz T, Matis M, Prevedel R, Luschnig S, Diz-Muñoz A, Burger M, Raz E.
Using migrating cells as probes to illuminate features in live embryonic tissues.
Sci Adv. 2020 Dec 4;6(49):eabc5546. doi: 10.1126/sciadv.abc5546. PMID: 33277250; PMCID: PMC7821905.
6: Smolič T, Tavčar P, Horvat A, Černe U, Halužan Vasle A, Tratnjek L, Kreft ME, Scholz N, Matis M, Petan T, Zorec R, Vardjan N.
Astrocytes in stress accumulate lipid droplets.
Glia. 2021 Jun;69(6):1540-1562. doi: 10.1002/glia.23978. Epub 2021 Feb 20. PMID: 33609060; PMCID: PMC8248329.
7: Panzade S, Matis M.
The Microtubule Minus-End Binding Protein Patronin Is Required for the Epithelial Remodeling in the Drosophila Abdomen.
Front Cell Dev Biol. 2021 Jul 21;9:682083. doi: 10.3389/fcell.2021.682083. PMID: 34368132; PMCID: PMC8335404.
AGs Merkel/Hoffmann
1: Hersch N, Wolters B, Ungvari Z, Gautam T, Deshpande D, Merkel R, Csiszar A, Hoffmann B, Csiszár A.
Biotin-conjugated fusogenic liposomes for high-quality cell purification.
J Biomater Appl. 2016 Jan;30(6):846-56. doi: 10.1177/0885328215603026. Epub 2015 Oct 15. PMID: 26475851.
2: Jahnel O, Hoffmann B, Merkel R, Bossinger O, Leube RE.
Mechanical Probing of the Intermediate Filament-Rich Caenorhabditis Elegans Intestine.
Methods Enzymol. 2016;568:681-706. doi: 10.1016/bs.mie.2015.08.030. Epub 2015 Nov 3. PMID: 26795489.
3: Braun T, Kleusch C, Naumovska E, Merkel R, Csiszár A.
A bioanalytical assay to distinguish cellular uptake routes for liposomes.
Cytometry A. 2016 Mar;89(3):301-8. doi: 10.1002/cyto.a.22792. Epub 2015 Nov 9. PMID: 26551759.
4: Moch M, Windoffer R, Schwarz N, Pohl R, Omenzetter A, Schnakenberg U, Herb F, Chaisaowong K, Merhof D, Ramms L, Fabris G, Hoffmann B, Merkel
R, Leube RE.
Effects of Plectin Depletion on Keratin Network Dynamics and Organization.
PLoS One. 2016 Mar 23;11(3):e0149106. doi: 10.1371/journal.pone.0149106. PMID: 27007410; PMCID: PMC4805305.
5: Monzel C, Schmidt D, Seifert U, Smith AS, Merkel R, Sengupta K.
Nanometric thermal fluctuations of weakly confined biomembranes measured with microsecond time-resolution.
Soft Matter. 2016 May 25;12(21):4755-68. doi: 10.1039/c6sm00412a. PMID: 27142463.
6: Leber Y, Ruparelia AA, Kirfel G, van der Ven PF, Hoffmann B, Merkel R, Bryson-Richardson RJ, Fürst DO.
Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage.
Hum Mol Genet. 2016 Jul 1;25(13):2776-2788. doi: 10.1093/hmg/ddw135. Epub 2016 May 19. PMID: 27206985.
7: Lämmel M, Jaschinski E, Merkel R, Kroy K.
Microstructure of Sheared Entangled Solutions of Semiflexible Polymers.
Polymers (Basel). 2016 Sep 28;8(10):353. doi: 10.3390/polym8100353. PMID: 30974627; PMCID: PMC6432445.
8: Soiné JR, Hersch N, Dreissen G, Hampe N, Hoffmann B, Merkel R, Schwarz US.
Measuring cellular traction forces on non-planar substrates.
Interface Focus. 2016 Oct 6;6(5):20160024. doi: 10.1098/rsfs.2016.0024. PMID: 27708757; PMCID: PMC4992736.
9: Sill C, Biehl R, Hoffmann B, Radulescu A, Appavou MS, Farago B, Merkel R, Richter D.
Structure and domain dynamics of human lactoferrin in solution and the influence of Fe(III)-ion ligand binding.
BMC Biophys. 2016 Nov 4;9:7. doi: 10.1186/s13628-016-0032-3. PMID: 27822363; PMCID: PMC5095980.
10: Kube S, Hersch N, Naumovska E, Gensch T, Hendriks J, Franzen A, Landvogt L, Siebrasse JP, Kubitscheck U, Hoffmann B, Merkel R, Csiszár A.
Fusogenic Liposomes as Nanocarriers for the Delivery of Intracellular Proteins.
Langmuir. 2017 Jan 31;33(4):1051-1059. doi: 10.1021/acs.langmuir.6b04304. Epub 2017 Jan 17. PMID: 28059515.
11: Marquardt C, Paulheim A, Rohbohm N, Merkel R, Sokolowski M.
A surface science compatible epifluorescence microscope for inspection of samples under ultra high vacuum and cryogenic conditions.
Rev Sci Instrum. 2017 Aug;88(8):083702. doi: 10.1063/1.4997953. PMID: 28863709.
12: Kolašinac R, Kleusch C, Braun T, Merkel R, Csiszár A.
Deciphering the Functional Composition of Fusogenic Liposomes.
Int J Mol Sci. 2018 Jan 24;19(2):346. doi: 10.3390/ijms19020346. PMID: 29364187; PMCID: PMC5855568.
13: Kugler EM, Michel K, Kirchenbüchler D, Dreissen G, Csiszár A, Merkel R, Schemann M, Mazzuoli-Weber G.
Sensitivity to Strain and Shear Stress of Isolated Mechanosensitive Enteric Neurons.
Neuroscience. 2018 Feb 21;372:213-224. doi: 10.1016/j.neuroscience.2017.12.052. Epub 2018 Jan 6. PMID: 29317262.
14: Heinrichs V, Dieluweit S, Stellbrink J, Pyckhout-Hintzen W, Hersch N, Richter D, Merkel R.
Chemically defined, ultrasoft PDMS elastomers with selectable elasticity for mechanobiology.
PLoS One. 2018 Apr 6;13(4):e0195180. doi: 10.1371/journal.pone.0195180. PMID: 29624610; PMCID: PMC5889068.
15: Zielinski A, Linnartz C, Pleschka C, Dreissen G, Springer R, Merkel R, Hoffmann B.
Reorientation dynamics and structural interdependencies of actin, microtubules and intermediate filaments upon cyclic stretch application.
Cytoskeleton (Hoboken). 2018 Sep;75(9):385-394. doi: 10.1002/cm.21470. Epub 2018 Oct 12. PMID: 30176121.
16: Noethel B, Ramms L, Dreissen G, Hoffmann M, Springer R, Rübsam M, Ziegler WH, Niessen CM, Merkel R, Hoffmann B.
Transition of responsive mechanosensitive elements from focal adhesions to adherens junctions on epithelial differentiation.
Mol Biol Cell. 2018 Sep 15;29(19):2317-2325. doi: 10.1091/mbc.E17-06-0387. Epub 2018 Jul 25. PMID: 30044710; PMCID: PMC6249805.
17: Fabris G, Lucantonio A, Hampe N, Noetzel E, Hoffmann B, DeSimone A, Merkel R.
Nanoscale Topography and Poroelastic Properties of Model Tissue Breast Gland Basement Membranes.
Biophys J. 2018 Nov 6;115(9):1770-1782. doi: 10.1016/j.bpj.2018.09.020. Epub 2018 Sep 29. PMID: 30322796; PMCID: PMC6224695.
18: Huang Y, Schell C, Huber TB, Şimşek AN, Hersch N, Merkel R, Gompper G, Sabass B.
Traction force microscopy with optimized regularization and automated Bayesian parameter selection for comparing cells.
Sci Rep. 2019 Jan 24;9(1):539. doi: 10.1038/s41598-018-36896-x. PMID: 30679578; PMCID: PMC6345967.
19: Kant S, Freytag B, Herzog A, Reich A, Merkel R, Hoffmann B, Krusche CA, Leube RE.
Desmoglein 2 mutation provokes skeletal muscle actin expression and accumulation at intercalated discs in murine hearts.
J Cell Sci. 2019 Feb 18;132(5):jcs199612. doi: 10.1242/jcs.199612. PMID: 30659114.
20: Litschko C, Brühmann S, Csiszár A, Stephan T, Dimchev V, Damiano-Guercio J, Junemann A, Körber S, Winterhoff M, Nordholz B, Ramalingam N,
Peckham M, Rottner K, Merkel R, Faix J.
Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins.
Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3594-3603. doi: 10.1073/pnas.1821638116. Epub 2019 Feb 11. PMID: 30808751; PMCID: PMC6397521.
21: Springer R, Zielinski A, Pleschka C, Hoffmann B, Merkel R.
Unbiased pattern analysis reveals highly diverse responses of cytoskeletal systems to cyclic straining.
PLoS One. 2019 Mar 13;14(3):e0210570. doi: 10.1371/journal.pone.0210570. PMID: 30865622; PMCID: PMC6415792.
22: Ahrens D, Rubner W, Springer R, Hampe N, Gehlen J, Magin TM, Hoffmann B, Merkel R.
A Combined AFM and Lateral Stretch Device Enables Microindentation Analyses of Living Cells at High Strains.
Methods Protoc. 2019 May 24;2(2):43. doi: 10.3390/mps2020043. PMID: 31164622; PMCID: PMC6632168.
23: Blaschke S, Vay SU, Pallast N, Rabenstein M, Abraham JA, Linnartz C, Hoffmann M, Hersch N, Merkel R, Hoffmann B, Fink GR, Rueger MA.
Substrate elasticity induces quiescence and promotes neurogenesis of primary neural stem cells-A biophysical in vitro model of the physiological cerebral
milieu.
J Tissue Eng Regen Med. 2019 Jun;13(6):960-972. doi: 10.1002/term.2838. Epub 2019 May 21. PMID: 30815982.
24: Abraham JA, Linnartz C, Dreissen G, Springer R, Blaschke S, Rueger MA, Fink GR, Hoffmann B, Merkel R.
Directing Neuronal Outgrowth and Network Formation of Rat Cortical Neurons by Cyclic Substrate Stretch.
Langmuir. 2019 Jun 11;35(23):7423-7431. doi: 10.1021/acs.langmuir.8b02003. Epub 2018 Aug 28. PMID: 30110535.
25: Tomasova L, Guttenberg Z, Hoffmann B, Merkel R.
Advanced 2D/3D cell migration assay for faster evaluation of chemotaxis of slow-moving cells.
PLoS One. 2019 Jul 17;14(7):e0219708. doi: 10.1371/journal.pone.0219708. PMID: 31314801; PMCID: PMC6636736.
26: Kolašinac R, Jaksch S, Dreissen G, Braeutigam A, Merkel R, Csiszár A.
Influence of Environmental Conditions on the Fusion of Cationic Liposomes with Living Mammalian Cells.
Nanomaterials (Basel). 2019 Jul 17;9(7):1025. doi: 10.3390/nano9071025. PMID: 31319557; PMCID: PMC6669649.
27: Kubo Y, Hoffmann B, Goltz K, Schnakenberg U, Jahr H, Merkel R, Schulze- Tanzil G, Pufe T, Tohidnezhad M.
Different Frequency of Cyclic Tensile Strain Relates to Anabolic/Catabolic Conditions Consistent with Immunohistochemical Staining Intensity in
Tenocytes.
Int J Mol Sci. 2020 Feb 6;21(3):1082. doi: 10.3390/ijms21031082. PMID: 32041254; PMCID: PMC7037470.
28: Pora A, Yoon S, Dreissen G, Hoffmann B, Merkel R, Windoffer R, Leube RE.
Regulation of keratin network dynamics by the mechanical properties of the environment in migrating cells.
Sci Rep. 2020 Mar 12;10(1):4574. doi: 10.1038/s41598-020-61242-5. PMID: 32165652; PMCID: PMC7067805.
29: Hoffmann M, Hersch N, Gerlach S, Dreissen G, Springer R, Merkel R, Csiszár A, Hoffmann B.
Complex Size and Surface Charge Determine Nucleic Acid Transfer by Fusogenic Liposomes.
Int J Mol Sci. 2020 Mar 24;21(6):2244. doi: 10.3390/ijms21062244. PMID: 32213928; PMCID: PMC7139958.
30: Keijdener H, Konrad J, Hoffmann B, Gerardo-Nava J, Rütten S, Merkel R, Vázquez-Jiménez J, Brook GA, Jockenhoevel S, Mela P.
A bench-top molding method for the production of cell-laden fibrin micro-fibers with longitudinal topography.
J Biomed Mater Res B Appl Biomater. 2020 May;108(4):1198-1212. doi: 10.1002/jbm.b.34469. Epub 2019 Aug 13. PMID: 31408584.
31: Stockhausen A, Bürgers J, Rodriguez-Gatica JE, Schweihoff J, Merkel R, Prigge JM, Schwarz MK, Kubitscheck U.
Hard-wired lattice light-sheet microscopy for imaging of expanded samples.
Opt Express. 2020 May 11;28(10):15587-15600. doi: 10.1364/OE.393728. PMID: 32403583.
32: Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, Hoffmann B, Merkel R, Niessen
CM, Dahl KN, Wickström SA.
Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage.
Cell. 2020 May 14;181(4):800-817.e22. doi: 10.1016/j.cell.2020.03.052. Epub 2020 Apr 16. PMID: 32302590; PMCID: PMC7237863.
33: Gaiko-Shcherbak A, Eschenbruch J, Kronenberg NM, Teske M, Wolters B, Springer R, Gather MC, Merkel R, Hoffmann B, Noetzel E.
Cell Force-Driven Basement Membrane Disruption Fuels EGF- and Stiffness-Induced Invasive Cell Dissemination from Benign Breast Gland Acini.
Int J Mol Sci. 2021 Apr 12;22(8):3962. doi: 10.3390/ijms22083962. PMID: 33921304; PMCID: PMC8070162.
34: Gögele C, Hoffmann C, Konrad J, Merkel R, Schwarz S, Tohidnezhad M, Hoffmann B, Schulze-Tanzil GG.
Correction to: Cyclically stretched ACL fibroblasts emigrating from spheroids adapt their cytoskeleton and ligament-related expression profile.
Cell Tissue Res. 2021 Jun;384(3):789. doi: 10.1007/s00441-021-03472-1. Erratum for: Cell Tissue Res. 2021 Jun;384(3):675-690. PMID: 33977325;
PMCID: PMC8496668.
35: Püllen R, Konrad J, Merkel R, Hoffmann B.
Skin under Strain: From Epithelial Model Tissues to Adult Epithelia.
Cells. 2021 Jul 20;10(7):1834. doi: 10.3390/cells10071834. PMID: 34360001; PMCID: PMC8304960.
36: Gögele C, Konrad J, Hahn J, Breier A, Schröpfer M, Meyer M, Merkel R, Hoffmann B, Schulze-Tanzil G.
Maintenance of Ligament Homeostasis of Spheroid- Colonized Embroidered and Functionalized Scaffolds after 3D Stretch.
Int J Mol Sci. 2021 Jul 30;22(15):8204. doi: 10.3390/ijms22158204. PMID: 34360970; PMCID: PMC8348491.
37: Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM,
Pokrzywa W, Rinschen MM, Wachten D, Warscheid B.
Maintaining proteostasis under mechanical stress.
EMBO Rep. 2021 Aug 4;22(8):e52507. doi: 10.15252/embr.202152507. Epub 2021 Jul 26. PMID: 34309183; PMCID: PMC8339670.
38: Eschenbruch J, Dreissen G, Springer R, Konrad J, Merkel R, Hoffmann B, Noetzel E.
From Microspikes to Stress Fibers: Actin Remodeling in Breast Acini Drives Myosin II-Mediated Basement Membrane Invasion.
Cells. 2021 Aug 4;10(8):1979. doi: 10.3390/cells10081979. PMID: 34440749; PMCID: PMC8394122.
39: Abraham JA, Blaschke S, Tarazi S, Dreissen G, Vay SU, Schroeter M, Fink GR, Merkel R, Rueger MA, Hoffmann B.
NSCs Under Strain-Unraveling the Mechanoprotective Role of Differentiating Astrocytes in a Cyclically Stretched Coculture With Differentiating Neurons.
Front Cell Neurosci. 2021 Sep 24;15:706585. doi: 10.3389/fncel.2021.706585. PMID: 34630042; PMCID: PMC8497758.
40: Lövenich L, Dreissen G, Hoffmann C, Konrad J, Springer R, Höhfeld J, Merkel R, Hoffmann B.
Strain-induced mechanoresponse depends on cell contractility and BAG3-mediated autophagy.
Mol Biol Cell. 2021 Oct 1;32(20):ar9. doi: 10.1091/mbc.E21-05-0254. Epub 2021 Aug 11. PMID: 34379447; PMCID: PMC8684750.
41: Gross A, Zhou B, Bewersdorf L, Schwarz N, Schacht GM, Boor P, Hoeft K, Hoffmann B, Fuchs E, Kramann R, Merkel R, Leube RE, Strnad P.
Desmoplakin Maintains Transcellular Keratin Scaffolding and Protects From Intestinal Injury.
Cell Mol Gastroenterol Hepatol. 2022;13(4):1181-1200. doi: 10.1016/j.jcmgh.2021.12.009. Epub 2021 Dec 17. PMID: 34929421; PMCID: PMC8873596.
42: Püllen R, Konrad J, Hoffmann B, Merkel R.
Cell Stretcher Assay to Analyze Mechanoresponses to Cyclic Stretching.
Methods Mol Biol. 2023;2600:91-105. doi: 10.1007/978-1-0716-2851-5_6. PMID: 36587092.
AG Niessen
1: Green KJ, Niessen CM.
Degrees of Freedom: Your Future in Biomedical Research.
J Invest Dermatol. 2016 Jun;136(6):1073-1076. doi: 10.1016/j.jid.2016.03.025. PMID: 27212644.
2: Rietscher K, Wolf A, Hause G, Rother A, Keil R, Magin TM, Glass M, Niessen CM, Hatzfeld M.
Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo.
J Invest Dermatol. 2016 Jul;136(7):1471-1478. doi: 10.1016/j.jid.2016.03.021. Epub 2016 Mar 28. PMID: 27033150.
3: Koehler S, Tellkamp F, Niessen CM, Bloch W, Kerjaschki D, Schermer B, Benzing T, Brinkkoetter PT.
Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.
Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F112-9. doi: 10.1152/ajprenal.00171.2016. Epub 2016 Apr 27. PMID: 27122542.
4: Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA.
Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment.
Nat Cell Biol. 2016 Aug;18(8):864-75. doi: 10.1038/ncb3387. Epub 2016 Jul 11. PMID: 27398909.
5: Wang S, Jacquemyn J, Murru S, Martinelli P, Barth E, Langer T, Niessen CM, Rugarli EI.
The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying.
PLoS Genet. 2016 Dec 2;12(12):e1006463. doi: 10.1371/journal.pgen.1006463. PMID: 27911893; PMCID: PMC5135034.
6: Mescher M, Jeong P, Knapp SK, Rübsam M, Saynisch M, Kranen M, Landsberg J, Schlaak M, Mauch C, Tüting T, Niessen CM, Iden S.
The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma.
J Exp Med. 2017 Feb;214(2):339-358. doi: 10.1084/jem.20160596. Epub 2017 Jan 17. PMID: 28096290; PMCID: PMC5294851.
7: Rahn E, Thier K, Petermann P, Rübsam M, Staeheli P, Iden S, Niessen CM, Knebel-Mörsdorf D.
Epithelial Barriers in Murine Skin during Herpes Simplex Virus 1 Infection: The Role of Tight Junction Formation.
J Invest Dermatol. 2017 Apr;137(4):884-893. doi: 10.1016/j.jid.2016.11.027. Epub 2016 Dec 6. PMID: 27939379.
8: Rübsam M, Mertz AF, Kubo A, Marg S, Jüngst C, Goranci-Buzhala G, Schauss AC, Horsley V, Dufresne ER, Moser M, Ziegler W, Amagai M, Wickström
SA, Niessen CM.
E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning.
Nat Commun. 2017 Nov 1;8(1):1250. doi: 10.1038/s41467-017-01170-7. PMID: 29093447; PMCID: PMC5665913.
9: Weiland D, Brachvogel B, Hornig-Do HT, Neuhaus JFG, Holzer T, Tobin DJ, Niessen CM, Wiesner RJ, Baris OR.
Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation.
J Invest Dermatol. 2018 Jan;138(1):132-140. doi: 10.1016/j.jid.2017.08.019. Epub 2017 Sep 1. PMID: 28867657.
10: Miroshnikova YA, Le HQ, Schneider D, Thalheim T, Rübsam M, Bremicker N, Polleux J, Kamprad N, Tarantola M, Wang I, Balland M, Niessen CM,
Galle J, Wickström SA.
Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification.
Nat Cell Biol. 2018 Jan;20(1):69-80. doi: 10.1038/s41556-017-0005-z. Epub 2017 Dec 11. PMID: 29230016.
11: Welcker D, Jain M, Khurshid S, Jokić M, Höhne M, Schmitt A, Frommolt P, Niessen CM, Spiro J, Persigehl T, Wittersheim M, Büttner R, Fanciulli M,
Schermer B, Reinhardt HC, Benzing T, Höpker K.
AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer.
Oncogene. 2018 Mar;37(11):1503-1518. doi: 10.1038/s41388-017-0054-6. Epub 2018 Jan 11. PMID: 29321668.
12: Urwyler-Rösselet C, Tanghe G, Leurs K, Gilbert B, De Rycke R, De Bruyne M, Lippens S, Bartunkova S, De Groote P, Niessen C, Haftek M,
Vandenabeele P, Declercq W.
Keratinocyte-Specific Ablation of RIPK4 Allows Epidermal Cornification but Impairs Skin Barrier Formation.
J Invest Dermatol. 2018 Jun;138(6):1268-1278. doi: 10.1016/j.jid.2017.12.031. Epub 2018 Jan 6. PMID: 29317263.
13: Shafraz O, Rübsam M, Stahley SN, Caldara AL, Kowalczyk AP, Niessen CM, Sivasankar S.
E-cadherin binds to desmoglein to facilitate desmosome assembly.
Elife. 2018 Jul 12;7:e37629. doi: 10.7554/eLife.37629. PMID: 29999492; PMCID: PMC6066328.
14: Vorhagen S, Kleefisch D, Persa OD, Graband A, Schwickert A, Saynisch M, Leitges M, Niessen CM, Iden S.
Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis.
Oncogene. 2018 Sep;37(37):5136-5146. doi: 10.1038/s41388-018-0313-1. Epub 2018 May 23. PMID: 29789715; PMCID: PMC6137026.
15: Noethel B, Ramms L, Dreissen G, Hoffmann M, Springer R, Rübsam M, Ziegler WH, Niessen CM, Merkel R, Hoffmann B.
Transition of responsive mechanosensitive elements from focal adhesions to adherens junctions on epithelial differentiation.
Mol Biol Cell. 2018 Sep 15;29(19):2317-2325. doi: 10.1091/mbc.E17-06-0387. Epub 2018 Jul 25. PMID: 30044710; PMCID: PMC6249805.
16: von Olshausen G, Quasdorff M, Bester R, Arzberger S, Ko C, van de Klundert M, Zhang K, Odenthal M, Ringelhan M, Niessen CM,
Protzer U. Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion.
Oncotarget. 2018 Sep 21;9(74):33947-33960. doi: 10.18632/oncotarget.26103. PMID: 30338037; PMCID: PMC6188061.
17: Wickström SA, Niessen CM.
Cell adhesion and mechanics as drivers of tissue organization and differentiation: local cues for large scale organization.
Curr Opin Cell Biol. 2018 Oct;54:89-97. doi: 10.1016/j.ceb.2018.05.003. Epub 2018 Jun 1. PMID: 29864721.
18: Rübsam M, Broussard JA, Wickström SA, Nekrasova O, Green KJ, Niessen CM.
Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary
Perspective.
Cold Spring Harb Perspect Biol. 2018 Nov 1;10(11):a029207. doi: 10.1101/cshperspect.a029207. PMID: 28893859; PMCID: PMC6211388.
19: Persa OD, Niessen CM.
Epithelial polarity limits EMT.
Nat Cell Biol. 2019 Mar;21(3):299-300. doi: 10.1038/s41556-019-0284-7. PMID: 30824839.
20: Polányi L, Niessen CM, Vohlen C, Stinn J, Kretschmer T, Jentgen V, Hirani D, Koningsbruggen-Rietschel SV, Dötsch J, Alejandre Alcazar MA.
Intrauterine growth restriction induces skin inflammation, increases TSLP and impairs epidermal barrier function.
J Mol Med (Berl). 2020 Feb;98(2):279-289. doi: 10.1007/s00109-019-01867-w. Epub 2020 Jan 7. PMID: 31912169.
21: Sahu P, Sussman DM, Rübsam M, Mertz AF, Horsley V, Dufresne ER, Niessen CM, Marchetti MC, Manning ML, Schwarz JM.
Small-scale demixing in confluent biological tissues.
Soft Matter. 2020 Apr 1;16(13):3325-3337. doi: 10.1039/c9sm01084j. PMID: 32196025.
22: Bayliss R, Wheeldon J, Caucheteux SM, Niessen CM, Piguet V.
Identification of Host Trafficking Genes Required for HIV-1 Virological Synapse Formation in Dendritic Cells.
J Virol. 2020 Apr 16;94(9):e01597-19. doi: 10.1128/JVI.01597-19. PMID: 32075937; PMCID: PMC7163131.
23: Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, Hoffmann B, Merkel R, Niessen
CM, Dahl KN, Wickström SA.
Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage.
Cell. 2020 May 14;181(4):800-817.e22. doi: 10.1016/j.cell.2020.03.052. Epub 2020 Apr 16. PMID: 32302590; PMCID: PMC7237863.
24: Green KJ, Roth-Carter Q, Niessen CM, Nichols SA.
Tracing the Evolutionary Origin of Desmosomes.
Curr Biol. 2020 May 18;30(10):R535-R543. doi: 10.1016/j.cub.2020.03.047. PMID: 32428495; PMCID: PMC7310670.
25: Rübsam M, Niessen CM.
Stretch exercises for stem cells expand the skin.
Nature. 2020 Aug;584(7820):196-198. doi: 10.1038/d41586-020-02158-y. PMID: 32728152.
26: Peters F, Tellkamp F, Brodesser S, Wachsmuth E, Tosetti B, Karow U, Bloch W, Utermöhlen O, Krönke M, Niessen CM.
Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis.
J Invest Dermatol. 2020 Oct;140(10):1927-1937.e5. doi: 10.1016/j.jid.2020.02.006. Epub 2020 Feb 22. PMID: 32092351.
27: Niessen CM, Plachta NA.
Emerging mechanisms driving cell differentiation in vivo.
Curr Opin Cell Biol. 2020 Dec;67:iii-v. doi: 10.1016/j.ceb.2020.10.003. Epub 2020 Nov 10. PMID: 33187809.
28: Jiang C, Javed A, Kaiser L, Nava MM, Xu R, Brandt DT, Zhao D, Mayer B, Fernández-Baldovinos J, Zhou L, Höß C, Sawmynaden K, Oleksy A, Matthews
D, Weinstein LS, Hahn H, Gröne HJ, Graumann PL, Niessen CM, Offermanns S, Wickström SA, Worzfeld T.
Mechanochemical control of epidermal stem cell divisions by B-plexins.
Nat Commun. 2021 Feb 26;12(1):1308. doi: 10.1038/s41467-021-21513-9. PMID: 33637728; PMCID: PMC7910479.
29: Persa OD, Koester J, Niessen CM.
Regulation of Cell Polarity and Tissue Architecture in Epidermal Aging and Cancer.
J Invest Dermatol. 2021 Apr;141(4S):1017-1023. doi: 10.1016/j.jid.2020.12.012. Epub 2021 Jan 30. PMID: 33531135.
30: Koester J, Miroshnikova YA, Ghatak S, Chacón-Martínez CA, Morgner J, Li X, Atanassov I, Altmüller J, Birk DE, Koch M, Bloch W, Bartusel M, Niessen
CM, Rada-Iglesias A, Wickström SA. Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter
accessibility.
Nat Cell Biol. 2021 Jul;23(7):771-781. doi: 10.1038/s41556-021-00705-x. Epub 2021 Jul 8. PMID: 34239060.
31: Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM,
Pokrzywa W, Rinschen MM, Wachten D, Warscheid B.
Maintaining proteostasis under mechanical stress.
EMBO Rep. 2021 Aug 4;22(8):e52507. doi: 10.15252/embr.202152507. Epub 2021 Jul 26. PMID: 34309183; PMCID: PMC8339670.
32: Tayem R, Niemann C, Pesch M, Morgner J, Niessen CM, Wickström SA, Aumailley M.
Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs.
J Invest Dermatol. 2021 Nov;141(11):2602-2610.e3. doi: 10.1016/j.jid.2021.04.008. Epub 2021 May 7. PMID: 33965403.
33: Koehler S, Odenthal J, Ludwig V, Unnersjö Jess D, Höhne M, Jüngst C, Grawe F, Helmstädter M, Janku JL, Bergmann C, Hoyer PF, Hagmann HH, Walz
G, Bloch W, Niessen C, Schermer B, Wodarz A, Denholm B, Benzing T, Iden S, Brinkkoetter PT.
Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to
maintain the kidney filtration barrier.
Kidney Int. 2022 Apr;101(4):733-751. doi: 10.1016/j.kint.2021.11.030. Epub 2021 Dec 17. PMID: 34929254.
34: Peskoller M, Bhosale A, Göbel K, Löhr J, Miceli S, Perot S, Persa O, Rübsam M, Shah J, Zhang H, Niessen CM.
How to Build and Regenerate a Functional Skin Barrier: The Adhesive and Cell Shaping Travels of a Keratinocyte.
J Invest Dermatol. 2022 Apr;142(4):1020-1025. doi: 10.1016/j.jid.2021.12.034. Epub 2022 Jan 17. PMID: 35051379.
35: Green KJ, Niessen CM, Rübsam M, Perez White BE, Broussard JA.
The Desmosome- Keratin Scaffold Integrates ErbB Family and Mechanical Signaling to Polarize Epidermal Structure and Function.
Front Cell Dev Biol. 2022 May 24;10:903696. doi: 10.3389/fcell.2022.903696. PMID: 35686051; PMCID: PMC9171019.
36: Rietscher K, Jahnke HG, Rübsam M, Lin EW, Has C, Omary MB, Niessen CM, Magin TM.
Kinase Inhibition by PKC412 Prevents Epithelial Sheet Damage in Autosomal Dominant Epidermolysis Bullosa Simplex through Keratin and Cell Contact
Stabilization.
J Invest Dermatol. 2022 Dec;142(12):3282-3293. doi: 10.1016/j.jid.2022.05.1088. Epub 2022 Jun 9. PMID: 35691363.
37: Spindler V, Gerull B, Green KJ, Kowalczyk AP, Leube R, Marian AJ, Milting H, Müller EJ, Niessen C, Payne AS, Schlegel N, Schmidt E, Strnad P, Tikkanen
R, Vielmuth F, Waschke J.
Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting.
J Cell Sci. 2023 Jan 1;136(1):jcs260832. doi: 10.1242/jcs.260832. Epub 2023 Jan 3. PMID: 36594662.
AG López-Posadas
1: López-Posadas R, Becker C, Günther C, Tenzer S, Amann K, Billmeier U, Atreya R, Fiorino G, Vetrano S, Danese S, Ekici AB, Wirtz S, Thonn V, Watson AJ,
Brakebusch C, Bergö M, Neurath MF, Atreya I.
Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation.
J Clin Invest. 2016 Feb;126(2):611-26. doi: 10.1172/JCI80997. Epub 2016 Jan 11. PMID: 26752649; PMCID: PMC4731169.
2: Fischer A, Zundler S, Atreya R, Rath T, Voskens C, Hirschmann S, López- Posadas R, Watson A, Becker C, Schuler G, Neufert C, Atreya I, Neurath MF.
Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo.
Gut. 2016 Oct;65(10):1642-64. doi: 10.1136/gutjnl-2015-310022. Epub 2015 Jul 24. PMID: 26209553; PMCID: PMC5036234.
3: Atreya I, Diall A, Dvorsky R, Atreya R, Henninger C, Grün M, Hofmann U, Schaeffeler E, López-Posadas R, Daehn I, Zenker S, Döbrönti M, Neufert C,
Billmeier U, Zundler S, Fritz G, Schwab M, Neurath MF.
Designer Thiopurine- analogues for Optimised Immunosuppression in Inflammatory Bowel Diseases.
J Crohns Colitis. 2016 Oct;10(10):1132-43. doi: 10.1093/ecco-jcc/jjw091. Epub 2016 Apr 25. PMID: 27112707.
4: López-Posadas R, Mascaraque C, González R, Suárez MD, Zarzuelo A, Martínez- Augustin O, Sánchez de Medina F.
The Bisphosphonate Pamidronate is an Intestinal Antiinflammatory Agent in Rat and Mouse Experimental Colitis.
Inflamm Bowel Dis. 2016 Nov;22(11):2549-2561. doi: 10.1097/MIB.0000000000000920. PMID: 27760076.
5: López-Posadas R, Neurath MF, Atreya I.
Molecular pathways driving disease- specific alterations of intestinal epithelial cells.
Cell Mol Life Sci. 2017 Mar;74(5):803-826. doi: 10.1007/s00018-016-2363-2. Epub 2016 Sep 13. PMID: 27624395.
6: Zundler S, Fischer A, Schillinger D, Binder MT, Atreya R, Rath T, Lopez- Pósadas R, Voskens CJ, Watson A, Atreya I, Neufert C, Neurath MF.
The α4β1 Homing Pathway Is Essential for Ileal Homing of Crohn's Disease Effector T Cells
In Vivo. Inflamm Bowel Dis. 2017 Mar;23(3):379-391. doi: 10.1097/MIB.0000000000001029. PMID: 28221249.
7: López-Posadas R, Stürzl M, Atreya I, Neurath MF, Britzen-Laurent N.
Interplay of GTPases and Cytoskeleton in Cellular Barrier Defects during Gut Inflammation.
Front Immunol. 2017 Oct 5;8:1240. doi: 10.3389/fimmu.2017.01240. PMID: 29051760; PMCID: PMC5633683.
8: Zundler S, Schillinger D, Fischer A, Atreya R, López-Posadas R, Watson A, Neufert C, Atreya I, Neurath MF.
Blockade of αEβ7 integrin suppresses accumulation of CD8<sup>+</sup> and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo.
Gut. 2017 Nov;66(11):1936-1948. doi: 10.1136/gutjnl-2016-312439. Epub 2016 Aug 19. PMID: 27543429.
9: Anzola A, González R, Gámez-Belmonte R, Ocón B, Aranda CJ, Martínez-Moya P, López-Posadas R, Hernández-Chirlaque C, Sánchez de Medina F, Martínez-Augustin O.
miR-146a regulates the crosstalk between intestinal epithelial cells, microbial components and inflammatory stimuli.
Sci Rep. 2018 Nov 26;8(1):17350. doi: 10.1038/s41598-018-35338-y. PMID: 30478292; PMCID: PMC6255912.
10: Zundler S, Becker E, Spocinska M, Slawik M, Parga-Vidal L, Stark R, Wiendl M, Atreya R, Rath T, Leppkes M, Hildner K, López-Posadas R, Lukassen S,
Ekici AB, Neufert C, Atreya I, van Gisbergen KPJM, Neurath MF.
Hobit- and Blimp-1-driven CD4<sup>+</sup> tissue-resident memory T cells control chronic intestinal inflammation.
Nat Immunol. 2019 Mar;20(3):288-300. doi: 10.1038/s41590-018-0298-5. Epub 2019 Jan 28. Erratum in: Nat Immunol. 2019 Apr;20(4):514.
PMID: 30692620.
11: Zundler S, Becker E, Spocinska M, Slawik M, Parga-Vidal L, Stark R, Wiendl M, Atreya R, Rath T, Leppkes M, Hildner K, López-Posadas R, Lukassen S,
Ekici AB, Neufert C, Atreya I, van Gisbergen KPJM, Neurath MF.
Author Correction: Hobit- and Blimp-1-driven CD4<sup>+</sup> tissue-resident memory T cells control chronic intestinal inflammation.
Nat Immunol. 2019 Apr;20(4):514. doi: 10.1038/s41590-019-0360-y. Erratum for: Nat Immunol. 2019 Mar;20(3):288-300. PMID: 30846879.
12: López-Posadas R, Fastancz P, Martínez-Sánchez LDC, Panteleev-Ivlev J, Thonn V, Kisseleva T, Becker LS, Schulz-Kuhnt A, Zundler S, Wirtz S, Atreya R,
Carlé B, Friedrich O, Schürmann S, Waldner MJ, Neufert C, Brakebusch CH, Bergö MO, Neurath MF, Atreya I.
Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice.
Gastroenterology. 2019 Nov;157(5):1293-1309. doi: 10.1053/j.gastro.2019.07.007. Epub 2019 Jul 11. PMID: 31302143.
13: Schulz-Kuhnt A, Greif V, Hildner K, Knipfer L, Döbrönti M, Zirlik S, Fuchs F, Atreya R, Zundler S, López-Posadas R, Neufert C, Ramming A, Kiefer A,
Grüneboom A, Strasser E, Wirtz S, Neurath MF, Atreya I.
ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on
Respiratory Failure.
Front Immunol. 2020 May 7;11:691. doi: 10.3389/fimmu.2020.00691. PMID: 32457736; PMCID: PMC7221160.
14: Martínez-Sánchez LD, Pradhan R, Ngo PA, Erkert L, Becker LS, Watson AJ, Atreya I, Neurath MF, López-Posadas R.
An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance.
J Vis Exp. 2020 Dec 3;(166). doi: 10.3791/60790. PMID: 33346195.
15: Pradhan R, Ngo PA, Martínez-Sánchez LD, Neurath MF, López-Posadas R.
Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases.
Cells. 2021 Jan 4;10(1):66. doi: 10.3390/cells10010066. PMID: 33406731; PMCID: PMC7823293.
16: Drobny A, Ngo PA, Neurath MF, Zunke F, López-Posadas R.
Molecular Communication Between Neuronal Networks and Intestinal Epithelial Cells in Gut Inflammation and Parkinson's Disease.
Front Med (Lausanne). 2021 Jul 22;8:655123. doi: 10.3389/fmed.2021.655123. PMID: 34368179; PMCID: PMC8339315.
17: Regensburger D, Tenkerian C, Pürzer V, Schmid B, Wohlfahrt T, Stolzer I, López-Posadas R, Günther C, Waldner MJ, Becker C, Sticht H, Petter K, Flierl
C, Gass T, Thoenissen T, Geppert CI, Britzen-Laurent N, Méniel VS, Ramming A, Stürzl M, Naschberger E.
Matricellular Protein SPARCL1 Regulates Blood Vessel Integrity and Antagonizes Inflammatory Bowel Disease.
Inflamm Bowel Dis. 2021 Aug 19;27(9):1491-1502. doi: 10.1093/ibd/izaa346. PMID: 33393634; PMCID: PMC8376124.
18: Stolzer I, Schickedanz L, Chiriac MT, López-Posadas R, Grassl GA, Mattner J, Wirtz S, Winner B, Neurath MF, Günther C.
STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8.
Mucosal Immunol. 2022 Jan;15(1):130-142. doi: 10.1038/s41385-021-00450-2. Epub 2021 Sep 8. PMID: 34497340; PMCID: PMC8732278.
19: Ngo PA, Neurath MF, López-Posadas R.
Impact of Epithelial Cell Shedding on Intestinal Homeostasis.
Int J Mol Sci. 2022 Apr 9;23(8):4160. doi: 10.3390/ijms23084160. PMID: 35456978; PMCID: PMC9027054.
20: Martínez-Sánchez LDC, Ngo PA, Pradhan R, Becker LS, Boehringer D, Soteriou D, Kubankova M, Schweitzer C, Koch T, Thonn V, Erkert L, Stolzer I,
Günther C, Becker C, Weigmann B, Klewer M, Daniel C, Amann K, Tenzer S, Atreya R, Bergo M, Brakebusch C, Watson AJM, Guck J, Fabry B, Atreya I,
Neurath MF, López-Posadas R.
Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation.
Gut. 2023 Feb;72(2):275-294. doi: 10.1136/gutjnl-2021-325520. Epub 2022 Mar 3. PMID: 35241625.
AG Schnittler
1: Seebach J, Cao J, Schnittler HJ.
Quantitative dynamics of VE-cadherin at endothelial cell junctions at a glance: basic requirements and current concepts.
Discoveries (Craiova). 2016 Aug 24;4(3):e63. doi: 10.15190/d.2016.10. PMID: 32309583; PMCID: PMC7159836.
2: Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, Brühmann S, Kollasser J, Block J, Dimchev G, Geyer M, Schnittler HJ, Brakebusch C,
Stradal TE, Carlier MF, Sixt M, Käs J, Faix J, Rottner K.
FMNL formins boost lamellipodial force generation.
Nat Commun. 2017 Mar 22;8:14832. doi: 10.1038/ncomms14832. PMID: 28327544; PMCID: PMC5364437.
3: Mewes M, Nedele J, Schelleckes K, Bondareva O, Lenders M, Kusche-Vihrog K, Schnittler HJ, Brand SM, Schmitz B, Brand E.
Salt-induced Na<sup>+</sup>/K<sup>+</sup>-ATPase-α/β expression involves soluble adenylyl cyclase in endothelial cells.
Pflugers Arch. 2017 Oct;469(10):1401-1412. doi: 10.1007/s00424-017-1999-6. Epub 2017 May 26. PMID: 28550472.
4: Bulk E, Kramko N, Liashkovich I, Glaser F, Schillers H, Schnittler HJ, Oberleithner H, Schwab A.
K<sub>Ca</sub>3.1 channel inhibition leads to an ICAM-1 dependent increase of cell-cell adhesion between A549 lung cancer and
HMEC-1 endothelial cells.
Oncotarget. 2017 Nov 28;8(68):112268-112282. doi: 10.18632/oncotarget.22735. PMID: 29348824; PMCID: PMC5762509.
5: Rezaei M, Cao J, Friedrich K, Kemper B, Brendel O, Grosser M, Adrian M, Baretton G, Breier G, Schnittler HJ.
The expression of VE-cadherin in breast cancer cells modulates cell dynamics as a function of tumor differentiation and promotes tumor-endothelial cell
interactions.
Histochem Cell Biol. 2018 Jan;149(1):15-30. doi: 10.1007/s00418-017-1619-8. Epub 2017 Nov 15. PMID: 29143117.
6: Waschke J, Bergmann M, Bräuer L, Brenner E, Buchhorn A, Deutsch A, Dokter M, Egu DT, Ergün S, Fassnacht U, Fietz D, Gundlach S, Heermann S, Hirt
B, Kugelmann D, Müller-Gerbl M, Neiss W, Nimtschke U, Plendl J, Pretterklieber M, Redies C, Scaal M, Schmidt MHH, Schmiedl A, Schnittler HJ,
Schomerus C, Sebestény T, Spittau B, Steiniger B, Tschernig T, Unverzagt A, Viebahn C, Voigt E, Weigner J, Weyers I, Winkelmann A, Winkler M, Paulsen F.
Recommendations of the working group of the Anatomische Gesellschaft on reduction of formaldehyde exposure in anatomical curricula and institutes.
Ann Anat. 2019 Jan;221:179-185. doi: 10.1016/j.aanat.2018.10.007. Epub 2018 Oct 25. PMID: 30393181.
7: Klusmeier N, Schnittler HJ, Seebach J.
A Novel Microscopic Assay Reveals Heterogeneous Regulation of Local Endothelial Barrier Function.
Biophys J. 2019 Apr 23;116(8):1547-1559. doi: 10.1016/j.bpj.2019.02.008. Epub 2019 Feb 22. PMID: 30878197; PMCID: PMC6486479.
8: Ghimire K, Zaric J, Alday-Parejo B, Seebach J, Bousquenaud M, Stalin J, Bieler G, Schnittler HJ, Rüegg C.
MAGI1 Mediates eNOS Activation and NO Production in Endothelial Cells in Response to Fluid Shear Stress.
Cells. 2019 Apr 27;8(5):388. doi: 10.3390/cells8050388. PMID: 31035633; PMCID: PMC6562810.
9: Schmitz B, Breulmann FL, Jubran B, Rolfes F, Thorwesten L, Krüger M, Klose A, Schnittler HJ, Brand SM.
A three-step approach identifies novel shear stress- sensitive endothelial microRNAs involved in vasculoprotective effects of high- intensity interval
training (HIIT). Oncotarget. 2019 Jun 4;10(38):3625-3640. PMID: 31217898; PMCID: PMC6557206.
10: Su N, März S, Plagemann T, Cao J, Schnittler HJ, Eter N, Heiduschka P.
Occurrence of Transmembrane Protein 119 in the Retina is Not Restricted to the Microglia: An Immunohistochemical Study.
Transl Vis Sci Technol. 2019 Dec 12;8(6):29. doi: 10.1167/tvst.8.6.29. PMID: 31853425; PMCID: PMC6908137.
11: Ali AAH, Schwarz-Herzke B, Rollenhagen A, Anstötz M, Holub M, Lübke J, Rose CR, Schnittler HJ, von Gall C.
Bmal1-deficiency affects glial synaptic coverage of the hippocampal mossy fiber synapse and the actin cytoskeleton in astrocytes.
Glia. 2020 May;68(5):947-962. doi: 10.1002/glia.23754. Epub 2019 Nov 19. PMID: 31743496.
12: Werner AC, Weckbach LT, Salvermoser M, Pitter B, Cao J, Maier-Begandt D, Forné I, Schnittler HJ, Walzog B, Montanez E.
Coronin 1B Controls Endothelial Actin Dynamics at Cell-Cell Junctions and Is Required for Endothelial Network Assembly.
Front Cell Dev Biol. 2020 Jul 31;8:708. doi: 10.3389/fcell.2020.00708. PMID: 32850828; PMCID: PMC7411154.
13: Hemkemeyer SA, Vollmer V, Schwarz V, Lohmann B, Honnert U, Taha M, Schnittler HJ, Bähler M.
Local Myo9b RhoGAP activity regulates cell motility.
J Biol Chem. 2021 Jan-Jun;296:100136. doi: 10.1074/jbc.RA120.013623. Epub 2020 Dec 6. PMID: 33268376; PMCID: PMC7949024.
14: Geisthoff U, Mahnken AH, Knaus P, Schnittler HJ, Stuck BA, Knöppel C.
Interdisziplinäres Management extrakranieller Gefäßanomalien [Interdisciplinary management of extracranial vascular anomalies].
HNO. 2022 May;70(5):380-388. German. doi: 10.1007/s00106-022-01163-z. Epub 2022 Apr 14. PMID: 35420312.
AG Schlegel/Waschke
1: Rötzer V, Hartlieb E, Winkler J, Walter E, Schlipp A, Sardy M, Spindler V, Waschke J.
Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing.
J Invest Dermatol. 2016 Jan;136(1):301-10. doi: 10.1038/JID.2015.380. PMID: 26763450.
2: Vielmuth F, Rötzer V, Hartlieb E, Hirneiß C, Waschke J, Spindler V.
Pemphigus Autoantibodies Induce Blistering in Human Conjunctiva.
Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4442-4449. doi: 10.1167/iovs.16-19582. PMID: 27750289.
3: Rötzer V, Egu D, Waschke J.
Meibomian gland cells display a differentiation- dependent composition of desmosomes.
Histochem Cell Biol. 2016 Dec;146(6):685-694. doi: 10.1007/s00418-016-1475-y. Epub 2016 Aug 18. PMID: 27539078.
4: Schinner C, Vielmuth F, Rötzer V, Hiermaier M, Radeva MY, Co TK, Hartlieb E, Schmidt A, Imhof A, Messoudi A, Horn A, Schlipp A, Spindler V, Waschke J.
Adrenergic Signaling Strengthens Cardiac Myocyte Cohesion.
Circ Res. 2017 Apr 14;120(8):1305-1317. doi: 10.1161/CIRCRESAHA.116.309631. Epub 2017 Mar 13. PMID: 28289018.
5: Walter E, Vielmuth F, Rotkopf L, Sárdy M, Horváth ON, Goebeler M, Schmidt E, Eming R, Hertl M, Spindler V, Waschke J.
Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus.
Sci Rep. 2017 Jun 15;7(1):3579. doi: 10.1038/s41598-017-03697-7. PMID: 28620161; PMCID: PMC5472593.
6: Ungewiß H, Vielmuth F, Suzuki ST, Maiser A, Harz H, Leonhardt H, Kugelmann D, Schlegel N, Waschke J.
Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase.
Sci Rep. 2017 Jul 24;7(1):6329. doi: 10.1038/s41598-017-06713-y. PMID: 28740231; PMCID: PMC5524837.
7: Vielmuth F, Wanuske MT, Radeva MY, Hiermaier M, Kugelmann D, Walter E, Buechau F, Magin TM, Waschke J, Spindler V.
Keratins Regulate the Adhesive Properties of Desmosomal Cadherins through Signaling.
J Invest Dermatol. 2018 Jan;138(1):121-131. doi: 10.1016/j.jid.2017.08.033. Epub 2017 Sep 9. PMID: 28899688.
8: Kugelmann D, Stratmann L, Nühlen N, Bork F, Hoffmann S, Samarbarksh G, Pferschy A, von der Heide AM, Eimannsberger A, Fallavollita P, Navab N, Waschke J.
An Augmented Reality magic mirror as additive teaching device for gross anatomy.
Ann Anat. 2018 Jan;215:71-77. doi: 10.1016/j.aanat.2017.09.011. Epub 2017 Oct 7. PMID: 29017852.
9: Spindler V, Eming R, Schmidt E, Amagai M, Grando S, Jonkman MF, Kowalczyk AP, Müller EJ, Payne AS, Pincelli C, Sinha AA, Sprecher E, Zillikens D, Hertl M, Waschke J.
Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus.
J Invest Dermatol. 2018 Jan;138(1):32-37. doi: 10.1016/j.jid.2017.06.022. Epub 2017 Oct 14. PMID: 29037765.
10: Spindler V, Waschke J.
Pemphigus-A Disease of Desmosome Dysfunction Caused by Multiple Mechanisms.
Front Immunol. 2018 Feb 1;9:136. doi: 10.3389/fimmu.2018.00136. PMID: 29449846; PMCID: PMC5799217.
11: Vielmuth F, Walter E, Fuchs M, Radeva MY, Buechau F, Magin TM, Spindler V, Waschke J.
Keratins Regulate p38MAPK-Dependent Desmoglein Binding Properties in Pemphigus.
Front Immunol. 2018 Mar 19;9:528. doi: 10.3389/fimmu.2018.00528. PMID: 29616033; PMCID: PMC5868517.
12: Vielmuth F, Spindler V, Waschke J.
Atomic Force Microscopy Provides New Mechanistic Insights into the Pathogenesis of Pemphigus.
Front Immunol. 2018 Mar 28;9:485. doi: 10.3389/fimmu.2018.00485. PMID: 29643851; PMCID: PMC5883869.
13: Schlögl E, Radeva MY, Vielmuth F, Schinner C, Waschke J, Spindler V.
Keratin Retraction and Desmoglein3 Internalization Independently Contribute to Autoantibody-Induced Cell Dissociation in Pemphigus Vulgaris.
Front Immunol. 2018 Apr 25;9:858. doi: 10.3389/fimmu.2018.00858. PMID: 29922278; PMCID: PMC5996934.
14: Kugelmann D, Rotkopf LT, Radeva MY, Garcia-Ponce A, Walter E, Waschke J.
Histamine causes endothelial barrier disruption via Ca<sup>2+</sup>-mediated RhoA activation and tension at adherens junctions.
Sci Rep. 2018 Sep 5;8(1):13229. doi: 10.1038/s41598-018-31408-3. PMID: 30185878; PMCID: PMC6125323.
15: Ungewiß H, Rötzer V, Meir M, Fey C, Diefenbacher M, Schlegel N, Waschke J.
Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion.
Cell Mol Life Sci. 2018 Nov;75(22):4251-4268. doi: 10.1007/s00018-018-2869-x. Epub 2018 Jul 6. Erratum in: Cell Mol Life Sci. 2019 Jul 10;: PMID: 29980799.
16: Gross A, Pack LAP, Schacht GM, Kant S, Ungewiss H, Meir M, Schlegel N, Preisinger C, Boor P, Guldiken N, Krusche CA, Sellge G, Trautwein C, Waschke J, Heuser A, Leube RE,
Strnad P.
Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury.
Mucosal Immunol. 2018 Nov;11(6):1630-1639. doi: 10.1038/s41385-018-0062-z. Epub 2018 Aug 16. PMID: 30115995.
17: Radeva MY, Walter E, Stach RA, Yazdi AS, Schlegel N, Sarig O, Sprecher E, Waschke J.
ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in Parallel to Increased ERK Activation.
Front Immunol. 2019 Apr 17;10:770. doi: 10.3389/fimmu.2019.00770. PMID: 31057535; PMCID: PMC6478701.
18: Walter E, Vielmuth F, Wanuske MT, Seifert M, Pollmann R, Eming R, Waschke J.
Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion.
Front Immunol. 2019 May 24;10:1128. doi: 10.3389/fimmu.2019.01128. PMID: 31178865; PMCID: PMC6543754.
19: Schinner C, Erber BM, Yeruva S, Waschke J.
Regulation of cardiac myocyte cohesion and gap junctions via desmosomal adhesion.
Acta Physiol (Oxf). 2019 Jun;226(2):e13242. doi: 10.1111/apha.13242. Epub 2019 Jan 19. PMID: 30582290.
20: Meir M, Burkard N, Ungewiß H, Diefenbacher M, Flemming S, Kannapin F, Germer CT, Schweinlin M, Metzger M, Waschke J, Schlegel N.
Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease.
J Clin Invest. 2019 Jun 17;129(7):2824-2840. doi: 10.1172/JCI120261. PMID: 31205031; PMCID: PMC6597228.
21: Fuchs M, Foresti M, Radeva MY, Kugelmann D, Keil R, Hatzfeld M, Spindler V, Waschke J, Vielmuth F.
Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering.
Cell Mol Life Sci. 2019 Sep;76(17):3465-3476. doi: 10.1007/s00018-019-03083-8. Epub 2019 Apr 4. PMID: 30949721.
22: Ungewiß H, Rötzer V, Meir M, Fey C, Diefenbacher M, Schlegel N, Waschke J.
Correction to: Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion.
Cell Mol Life Sci. 2019 Sep;76(17):3477. doi: 10.1007/s00018-019-03210-5. Erratum for: Cell Mol Life Sci. 2018 Nov;75(22):4251-4268. PMID: 31292664.
23: Egu DT, Kugelmann D, Waschke J.
Role of PKC and ERK Signaling in Epidermal Blistering and Desmosome Regulation in Pemphigus.
Front Immunol. 2019 Dec 6;10:2883. doi: 10.3389/fimmu.2019.02883. PMID: 31867019; PMCID: PMC6910072.
24: Schinner C, Erber BM, Yeruva S, Schlipp A, Rötzer V, Kempf E, Kant S, Leube RE, Mueller TD, Waschke J.
Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy.
JCI Insight. 2020 May 7;5(9):e130141. doi: 10.1172/jci.insight.130141. PMID: 32376797; PMCID: PMC7253015.
25: Yeruva S, Kempf E, Egu DT, Flaswinkel H, Kugelmann D, Waschke J.
Adrenergic Signaling-Induced Ultrastructural Strengthening of Intercalated Discs via Plakoglobin Is Crucial for Positive Adhesiotropy in Murine Cardiomyocytes.
Front Physiol. 2020 May 21;11:430. doi: 10.3389/fphys.2020.00430. PMID: 32508670; PMCID: PMC7253624.
26: Schinner C, Olivares-Florez S, Schlipp A, Trenz S, Feinendegen M, Flaswinkel H, Kempf E, Egu DT, Yeruva S, Waschke J.
The inotropic agent digitoxin strengthens desmosomal adhesion in cardiac myocytes in an ERK1/2-dependent manner.
Basic Res Cardiol. 2020 Jun 17;115(4):46. doi: 10.1007/s00395-020-0805-3. PMID: 32556797; PMCID: PMC7299919.
27: Shoykhet M, Trenz S, Kempf E, Williams T, Gerull B, Schinner C, Yeruva S, Waschke J.
Cardiomyocyte adhesion and hyperadhesion differentially require ERK1/2 and plakoglobin.
JCI Insight. 2020 Sep 17;5(18):e140066. doi: 10.1172/jci.insight.140066. PMID: 32841221; PMCID: PMC7526536.
28: García-Ponce A, Schuster K, Døskeland SO, Reed RK, Curry FE, Waschke J, Radeva MY.
Epac1 Is Crucial for Maintenance of Endothelial Barrier Function through A Mechanism Partly Independent of Rac1.
Cells. 2020 Sep 25;9(10):2170. doi: 10.3390/cells9102170. PMID: 32992982; PMCID: PMC7601253.
29: Meir M, Salm J, Fey C, Schweinlin M, Kollmann C, Kannapin F, Germer CT, Waschke J, Beck C, Burkard N, Metzger M, Schlegel N.
Enteroids Generated from Patients with Severe Inflammation in Crohn's Disease Maintain Alterations of Junctional Proteins.
J Crohns Colitis. 2020 Oct 5;14(10):1473-1487. doi: 10.1093/ecco-jcc/jjaa085. PMID: 32342109.
30: Fuchs M, Sigmund AM, Waschke J, Vielmuth F.
Desmosomal Hyperadhesion Is Accompanied with Enhanced Binding Strength of Desmoglein 3 Molecules.
Biophys J. 2020 Oct 20;119(8):1489-1500. doi: 10.1016/j.bpj.2020.09.008. Epub 2020 Sep 21. PMID: 33031738; PMCID: PMC7642361.
31: Meier K, Holstein J, Solimani F, Waschke J, Ghoreschi K.
Case Report: Apremilast for Therapy-Resistant Pemphigus Vulgaris.
Front Immunol. 2020 Oct 27;11:588315. doi: 10.3389/fimmu.2020.588315. PMID: 33193415; PMCID: PMC7653172.
32: Sigmund AM, Steinert LS, Egu DT, Bayerbach FC, Waschke J, Vielmuth F.
Dsg2 Upregulation as a Rescue Mechanism in Pemphigus.
Front Immunol. 2020 Oct 28;11:581370. doi: 10.3389/fimmu.2020.581370. PMID: 33193387; PMCID: PMC7655986.
33: Schlegel N, Boerner K, Waschke J.
Targeting desmosomal adhesion and signalling for intestinal barrier stabilization in inflammatory bowel diseases- Lessons from experimental models and patients.
Acta Physiol (Oxf). 2021 Jan;231(1):e13492. doi: 10.1111/apha.13492. Epub 2020 May 22. PMID: 32419327.
34: Meir M, Kannapin F, Diefenbacher M, Ghoreishi Y, Kollmann C, Flemming S, Germer CT, Waschke J, Leven P, Schneider R, Wehner S, Burkard N, Schlegel N.
Intestinal Epithelial Barrier Maturation by Enteric Glial Cells Is GDNF- Dependent.
Int J Mol Sci. 2021 Feb 14;22(4):1887. doi: 10.3390/ijms22041887. PMID: 33672854; PMCID: PMC7917776.
35: Wanuske MT, Brantschen D, Schinner C, Stüdle C, Walter E, Hiermaier M, Vielmuth F, Waschke J, Spindler V.
Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion.
Acta Physiol (Oxf). 2021 Apr;231(4):e13609. doi: 10.1111/apha.13609. Epub 2021 Jan 19. PMID: 33354837.
36: Hiermaier M, Kliewe F, Schinner C, Stüdle C, Maly IP, Wanuske MT, Rötzer V, Endlich N, Vielmuth F, Waschke J, Spindler V.
The Actin-Binding Protein α-Adducin Modulates Desmosomal Turnover and Plasticity.
J Invest Dermatol. 2021 May;141(5):1219-1229.e11. doi: 10.1016/j.jid.2020.09.022. Epub 2020 Oct 22. PMID: 33098828.
37: Schmitt T, Waschke J.
Autoantibody-Specific Signalling in Pemphigus.
Front Med (Lausanne). 2021 Aug 9;8:701809. doi: 10.3389/fmed.2021.701809. PMID: 34434944; PMCID: PMC8381052.
38: Burkard N, Meir M, Kannapin F, Otto C, Petzke M, Germer CT, Waschke J, Schlegel N.
Desmoglein2 Regulates Claudin2 Expression by Sequestering PI-3-Kinase in Intestinal Epithelial Cells.
Front Immunol. 2021 Sep 30;12:756321. doi: 10.3389/fimmu.2021.756321. PMID: 34659262; PMCID: PMC8514949.
39: Hudemann C, Maglie R, Llamazares-Prada M, Beckert B, Didona D, Tikkanen R, Schmitt T, Hashimoto T, Waschke J, Hertl M, Eming R.
Human Desmocollin 3‒Specific IgG Antibodies Are Pathogenic in a Humanized HLA Class II Transgenic Mouse Model of Pemphigus.
J Invest Dermatol. 2022 Mar;142(3 Pt B):915-923.e3. doi: 10.1016/j.jid.2021.06.017. Epub 2021 Jul 13. PMID: 34265330.
40: Egu DT, Schmitt T, Sigmund AM, Waschke J.
Electron microscopy reveals that phospholipase C and Ca<sup>2+</sup> signaling regulate keratin filament uncoupling from desmosomes in Pemphigus.
Ann Anat. 2022 Apr;241:151904. doi: 10.1016/j.aanat.2022.151904. Epub 2022 Feb 4. PMID: 35131450.
41: Fuchs M, Kugelmann D, Schlegel N, Vielmuth F, Waschke J.
Desmoglein 2 can undergo Ca<sup>2+</sup>-dependent interactions with both desmosomal and classical cadherins including E-cadherin and N-cadherin.
Biophys J. 2022 Apr 5;121(7):1322-1335. doi: 10.1016/j.bpj.2022.02.023. Epub 2022 Feb 17. PMID: 35183520; PMCID: PMC9034291.
42: Büchau F, Vielmuth F, Waschke J, Magin TM.
Bidirectional regulation of desmosome hyperadhesion by keratin isotypes and desmosomal components.
Cell Mol Life Sci. 2022 Apr 5;79(5):223. doi: 10.1007/s00018-022-04244-y. PMID: 35380280; PMCID: PMC8983532.
43: Hiermaier M, Kugelmann D, Radeva MY, Didona D, Ghoreschi K, Farzan S, Hertl M, Waschke J.
Pemphigus Foliaceus Autoantibodies Induce Redistribution Primarily of Extradesmosomal Desmoglein 1 in the Cell Membrane.
Front Immunol. 2022 May 12;13:882116. doi: 10.3389/fimmu.2022.882116. PMID: 35634274; PMCID: PMC9134081.
44: Egu DT, Schmitt T, Waschke J.
Mechanisms Causing Acantholysis in Pemphigus- Lessons from Human Skin.
Front Immunol. 2022 May 20;13:884067. doi:n 10.3389/fimmu.2022.884067. PMID: 35720332; PMCID: PMC9205406.
45: Schmitt T, Pircher J, Steinert L, Meier K, Ghoreschi K, Vielmuth F, Kugelmann D, Waschke J.
Dsg1 and Dsg3 Composition of Desmosomes Across Human Epidermis and Alterations in Pemphigus Vulgaris Patient Skin.
Front Immunol. 2022 May 25;13:884241. doi: 10.3389/fimmu.2022.884241. PMID: 35711465; PMCID: PMC9196036.
46: Kugelmann D, Anders M, Sigmund AM, Egu DT, Eichkorn RA, Yazdi AS, Sárdy M, Hertl M, Didona D, Hashimoto T, Waschke J.
Role of ADAM10 and ADAM17 in the Regulation of Keratinocyte Adhesion in Pemphigus Vulgaris.
Front Immunol. 2022 Jun 30;13:884248. doi: 10.3389/fimmu.2022.884248. PMID: 35844545; PMCID: PMC9279611.
47: Moztarzadeh S, Radeva MY, Sepic S, Schuster K, Hamad I, Waschke J, García- Ponce A.
Lack of adducin impairs the stability of endothelial adherens and tight junctions and may be required for cAMP-Rac1-mediated endothelial barrier stabilization.
Sci Rep. 2022 Sep 2;12(1):14940. doi: 10.1038/s41598-022-18964-5. PMID: 36056066; PMCID: PMC9440001.
48: Nagler S, Ghoreishi Y, Kollmann C, Kelm M, Gerull B, Waschke J, Burkard N, Schlegel N.
Plakophilin 2 regulates intestinal barrier function by modulating protein kinase C activity in vitro.
Tissue Barriers. 2022 Oct 24:2138061. doi: 10.1080/21688370.2022.2138061. Epub ahead of print. PMID: 36280901.
49: Yeruva S, Körber L, Hiermaier M, Egu DT, Kempf E, Waschke J.
Cholinergic signaling impairs cardiomyocyte cohesion.
Acta Physiol (Oxf). 2022 Nov;236(3):e13881. doi: 10.1111/apha.13881. Epub 2022 Sep 16. PMID: 36039679.
50: Yeruva S, Waschke J.
Structure and regulation of desmosomes in intercalated discs: Lessons from epithelia.
J Anat. 2023 Jan;242(1):81-90. doi: 10.1111/joa.13634. Epub 2022 Feb 6. PMID: 35128661; PMCID: PMC9773171.
51: Spindler V, Gerull B, Green KJ, Kowalczyk AP, Leube R, Marian AJ, Milting H, Müller EJ, Niessen C, Payne AS, Schlegel N, Schmidt E, Strnad P, Tikkanen R, Vielmuth F, Waschke J.
Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting.
J Cell Sci. 2023 Jan 1;136(1):jcs260832. doi: 10.1242/jcs.260832. Epub 2023 Jan 3. PMID: 36594662.
52: Fuchs M, Radeva MY, Spindler V, Vielmuth F, Kugelmann D, Waschke J.
Cytoskeletal anchorage of different Dsg3 pools revealed by combination of hybrid STED/SMFS-AFM.
Cell Mol Life Sci. 2023 Jan 5;80(1):25. doi: 10.1007/s00018-022-04681-9. PMID: 36602635; PMCID: PMC9816259.
53: Sigmund AM, Winkler M, Engelmayer S, Kugelmann D, Egu DT, Steinert LS, Fuchs M, Hiermair M, Radeva MY, Bayerbach FC, Butz E, Kotschi S, Hudemann C, Hertl M,
Yeruva S, Schmidt E, Yazdi AS, Ghoreschi K, Vielmuth F, Waschke J.
Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus.
Nat Commun. 2023 Jan 9;14(1):116. doi: 10.1038/s41467-022-35741-0. PMID: 36624106; PMCID: PMC9829900.
54: Hudemann C, Exner Y, Pollmann R, Schneider K, Zakrzewicz A, Feldhoff S, Schmidt T, Spindler V, Rafei-Shamsabadi D, Völlner F, Waschke J, Tikkanen R, Hertl M, Eming R.
IgG against the Membrane-Proximal Portion of the Desmoglein 3 Ectodomain Induces Loss of Keratinocyte Adhesion, a Hallmark in Pemphigus Vulgaris.
J Invest Dermatol. 2023 Feb;143(2):254-263.e3. doi: 10.1016/j.jid.2022.07.030. Epub 2022 Sep 9. PMID: 36089007.
55: Price AJ, Cost AL, Ungewiß H, Waschke J, Dunn AR, Grashoff C.
Mechanical loading of desmosomes depends on the magnitude and orientation of external stress.
Nat Commun. 2018 Dec 11;9(1):5284. doi: 10.1038/s41467-018-07523-0. PMID: 30538252; PMCID: PMC6290003.
56: Meir M, Flemming S, Burkard N, Wagner J, Germer CT, Schlegel N.
The glial cell-line derived neurotrophic factor: a novel regulator of intestinal barrier function in health and disease.
Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1118-23. doi: 10.1152/ajpgi.00125.2016. Epub 2016 May 5. PMID: 27151942.
57: Flemming S, Burkard N, Meir M, Schick MA, Germer CT, Schlegel N.
Sphingosine-1-Phosphate Receptor-1 Agonist Sew2871 Causes Severe Cardiac Side Effects and Does Not Improve Microvascular Barrier Breakdown in Sepsis.
Shock. 2018 Jan;49(1):71-81. doi: 10.1097/SHK.0000000000000908. PMID: 28538086.
58: Chánez-Paredes S, Montoya-García A, Castro-Ochoa KF, García-Cordero J, Cedillo-Barrón L, Shibayama M, Nava P, Flemming S, Schlegel N, Gautreau AM, Vargas-Robles H, Mondragón-Flores R, Schnoor M.
The Arp2/3 Inhibitory Protein Arpin Is Required for Intestinal Epithelial Barrier Integrity.
Front Cell Dev Biol. 2021 May 3;9:625719. doi: 10.3389/fcell.2021.625719. PMID: 34012961; PMCID: PMC8128147.
AG Spindler
1: Rötzer V, Hartlieb E, Winkler J, Walter E, Schlipp A, Sardy M, Spindler V, Waschke J.
Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing.
J Invest Dermatol. 2016 Jan;136(1):301-10. doi: 10.1038/JID.2015.380. PMID: 26763450.
2: Vielmuth F, Schumann RG, Spindler V, Wolf A, Scheler R, Mayer WJ, Henrich PB, Haritoglou C.
Biomechanical Properties of the Internal Limiting Membrane after Intravitreal Ocriplasmin Treatment.
Ophthalmologica. 2016;235(4):233-40. doi: 10.1159/000444508. Epub 2016 Apr 28. PMID: 27120551.
3: Vielmuth F, Rötzer V, Hartlieb E, Hirneiß C, Waschke J, Spindler V.
Pemphigus Autoantibodies Induce Blistering in Human Conjunctiva.
Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4442-4449. doi: 10.1167/iovs.16-19582. PMID: 27750289.
4: Vielmuth F, Schumann RG, Spindler V, Wolf A, Scheler R, Mayer WJ, Henrich PB, Haritoglou C.
[Propiedades biomecánicas de la membrana limitante interna tras recibir tratamiento intravítreo con ocriplasmina].
Ophthalmologica. 2017;238 Suppl 1:1-8. Spanish. doi: 10.1159/000477510. Epub 2017 Jul 11. PMID: 28693020.
5: Schinner C, Vielmuth F, Rötzer V, Hiermaier M, Radeva MY, Co TK, Hartlieb E, Schmidt A, Imhof A, Messoudi A, Horn A, Schlipp A, Spindler V, Waschke J.
Adrenergic Signaling Strengthens Cardiac Myocyte Cohesion.
Circ Res. 2017 Apr 14;120(8):1305-1317. doi: 10.1161/CIRCRESAHA.116.309631. Epub 2017 Mar 13. PMID: 28289018.
6: Walter E, Vielmuth F, Rotkopf L, Sárdy M, Horváth ON, Goebeler M, Schmidt E, Eming R, Hertl M, Spindler V, Waschke J.
Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus.
Sci Rep. 2017 Jun 15;7(1):3579. doi: 10.1038/s41598-017-03697-7. PMID: 28620161; PMCID: PMC5472593.
7: Hütz K, Zeiler J, Sachs L, Ormanns S, Spindler V.
Loss of desmoglein 2 promotes tumorigenic behavior in pancreatic cancer cells.
Mol Carcinog. 2017 Aug;56(8):1884-1895. doi: 10.1002/mc.22644. Epub 2017 Mar 30. PMID: 28277619.
8: Vielmuth F, Wanuske MT, Radeva MY, Hiermaier M, Kugelmann D, Walter E, Buechau F, Magin TM, Waschke J, Spindler V.
Keratins Regulate the Adhesive Properties of Desmosomal Cadherins through Signaling.
J Invest Dermatol. 2018 Jan;138(1):121-131. doi: 10.1016/j.jid.2017.08.033. Epub 2017 Sep 9. PMID: 28899688.
9: Spindler V, Eming R, Schmidt E, Amagai M, Grando S, Jonkman MF, Kowalczyk AP, Müller EJ, Payne AS, Pincelli C, Sinha AA, Sprecher E, Zillikens D, Hertl M, Waschke J.
Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus.
J Invest Dermatol. 2018 Jan;138(1):32-37. doi: 10.1016/j.jid.2017.06.022. Epub 2017 Oct 14. PMID: 29037765.
10: Spindler V, Waschke J.
Pemphigus-A Disease of Desmosome Dysfunction Caused by Multiple Mechanisms.
Front Immunol. 2018 Feb 1;9:136. doi: 10.3389/fimmu.2018.00136. PMID: 29449846; PMCID: PMC5799217.
11: Vielmuth F, Walter E, Fuchs M, Radeva MY, Buechau F, Magin TM, Spindler V, Waschke J.
Keratins Regulate p38MAPK-Dependent Desmoglein Binding Properties in Pemphigus.
Front Immunol. 2018 Mar 19;9:528. doi: 10.3389/fimmu.2018.00528. PMID: 29616033; PMCID: PMC5868517.
12: Vielmuth F, Spindler V, Waschke J.
Atomic Force Microscopy Provides New Mechanistic Insights into the Pathogenesis of Pemphigus.
Front Immunol. 2018 Mar 28;9:485. doi: 10.3389/fimmu.2018.00485. PMID: 29643851; PMCID: PMC5883869.
13: Schlögl E, Radeva MY, Vielmuth F, Schinner C, Waschke J, Spindler V.
Keratin Retraction and Desmoglein3 Internalization Independently Contribute to Autoantibody-Induced Cell Dissociation in Pemphigus Vulgaris.
Front Immunol. 2018 Apr 25;9:858. doi: 10.3389/fimmu.2018.00858. PMID: 29922278; PMCID: PMC5996934.
14: Kugelmann D, Rötzer V, Walter E, Egu DT, Fuchs MT, Vielmuth F, Vargas-Robles H, Schnoor M, Hertl M, Eming R, Rottner K, Schmidt A, Spindler V, Waschke J.
Role of Src and Cortactin in Pemphigus Skin Blistering.
Front Immunol. 2019 Apr 4;10:626. doi: 10.3389/fimmu.2019.00626. PMID: 31024527; PMCID: PMC6461052.
15: Fuchs M, Foresti M, Radeva MY, Kugelmann D, Keil R, Hatzfeld M, Spindler V, Waschke J, Vielmuth F.
Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering.
Cell Mol Life Sci. 2019 Sep;76(17):3465-3476. doi: 10.1007/s00018-019-03083-8. Epub 2019 Apr 4. PMID: 30949721.
16: Wanuske MT, Brantschen D, Schinner C, Stüdle C, Walter E, Hiermaier M, Vielmuth F, Waschke J, Spindler V.
Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion.
Acta Physiol (Oxf). 2021 Apr;231(4):e13609. doi: 10.1111/apha.13609. Epub 2021 Jan 19. PMID: 33354837.
17: Hiermaier M, Kliewe F, Schinner C, Stüdle C, Maly IP, Wanuske MT, Rötzer V, Endlich N, Vielmuth F, Waschke J, Spindler V.
The Actin-Binding Protein α-Adducin Modulates Desmosomal Turnover and Plasticity.
J Invest Dermatol. 2021 May;141(5):1219-1229.e11. doi: 10.1016/j.jid.2020.09.022. Epub 2020 Oct 22. PMID: 33098828.
18: Mitgau J, Franke J, Schinner C, Stephan G, Berndt S, Placantonakis DG, Kalwa H, Spindler V, Wilde C, Liebscher I.
The N Terminus of Adhesion G Protein- Coupled Receptor GPR126/ADGRG6 as Allosteric Force Integrator.
Front Cell Dev Biol. 2022 Jun 23;10:873278. doi: 10.3389/fcell.2022.873278. PMID: 35813217; PMCID: PMC9259995.
19: Schinner C, Xu L, Franz H, Zimmermann A, Wanuske MT, Rathod M, Hanns P, Geier F, Pelczar P, Liang Y, Lorenz V, Stüdle C, Maly PI, Kauferstein S, Beckmann BM, Sheikh F, Kuster
GM, Spindler V.
Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by Involving an Integrin-αVβ6/TGF-β Signaling Cascade.
Circulation. 2022 Nov 22;146(21):1610-1626. doi: 10.1161/CIRCULATIONAHA.121.057329. Epub 2022 Oct 21. PMID: 36268721; PMCID: PMC9674449.
20: Fuchs M, Radeva MY, Spindler V, Vielmuth F, Kugelmann D, Waschke J.
Cytoskeletal anchorage of different Dsg3 pools revealed by combination of hybrid STED/SMFS-AFM.
Cell Mol Life Sci. 2023 Jan 5;80(1):25. doi: 10.1007/s00018-022-04681-9. PMID: 36602635; PMCID: PMC9816259.
21: Hudemann C, Exner Y, Pollmann R, Schneider K, Zakrzewicz A, Feldhoff S, Schmidt T, Spindler V, Rafei-Shamsabadi D, Völlner F, Waschke J, Tikkanen R, Hertl M, Eming R.
IgG against the Membrane-Proximal Portion of the Desmoglein 3 Ectodomain Induces Loss of Keratinocyte Adhesion, a Hallmark in Pemphigus Vulgaris.
J Invest Dermatol. 2023 Feb;143(2):254-263.e3. doi: 10.1016/j.jid.2022.07.030. Epub 2022 Sep 9. PMID: 36089007.
AG Strnad
1: Gross A, Pack LAP, Schacht GM, Kant S, Ungewiss H, Meir M, Schlegel N, Preisinger C, Boor P, Guldiken N, Krusche CA, Sellge G, Trautwein C, Waschke J, Heuser A, Leube RE,
Strnad P.
Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury.
Mucosal Immunol. 2018 Nov;11(6):1630-1639. doi: 10.1038/s41385-018-0062-z. Epub 2018 Aug 16. PMID: 30115995.
2: Kuscuoglu D, Bewersdorf L, Wenzel K, Gross A, Kobazi Ensari G, Luo Y, Kilic K, Hittatiya K, Golob-Schwarzl N, Leube RE, Preisinger C, George J, Metwally M, Eslam M, Lampertico P,
Petta S, Mangia A, Berg T, Boonstra A, Brouwer WP, Abate ML, Loglio A, Sutton A, Nahon P, Schaefer B, Zoller H, Aigner E, Trautwein C, Haybaeck J, Strnad P.
Dual proteotoxic stress accelerates liver injury via activation of p62-Nrf2.
J Pathol. 2021 May;254(1):80-91. doi: 10.1002/path.5643. Epub 2021 Mar 18. PMID: 33586163.
3: Gross A, Zhou B, Bewersdorf L, Schwarz N, Schacht GM, Boor P, Hoeft K, Hoffmann B, Fuchs E, Kramann R, Merkel R, Leube RE, Strnad P.
Desmoplakin Maintains Transcellular Keratin Scaffolding and Protects From Intestinal Injury.
Cell Mol Gastroenterol Hepatol. 2022;13(4):1181-1200. doi: 10.1016/j.jcmgh.2021.12.009. Epub 2021 Dec 17. PMID: 34929421; PMCID: PMC8873596.
AG Wodarz
1: Berger H, Wodarz A, Borchers A.
PTK7 Faces the Wnt in Development and Disease.
Front Cell Dev Biol. 2017 Apr 5;5:31. doi: 10.3389/fcell.2017.00031. PMID: 28424771; PMCID: PMC5380734.
2: Januschke J, Wodarz A.
Notch Signaling: Where Is the Action?
Curr Biol. 2017 Aug 7;27(15):R760-R762. doi: 10.1016/j.cub.2017.06.072. PMID: 28787607.
3: Beati H, Peek I, Hordowska P, Honemann-Capito M, Glashauser J, Renschler FA, Kakanj P, Ramrath A, Leptin M, Luschnig S, Wiesner S, Wodarz A.
The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis.
J Cell Biol. 2018 Mar 5;217(3):1079-1095. doi: 10.1083/jcb.201610098. Epub 2018 Jan 22. PMID: 29358210; PMCID: PMC5839775.
4: Rust K, Tiwari MD, Mishra VK, Grawe F, Wodarz A.
Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity in <i>Drosophila</i>.
EMBO J. 2018 Aug 15;37(16):e98659. doi: 10.15252/embj.201798659. Epub 2018 Jul 11. PMID: 29997178; PMCID: PMC6092623.
5: Ripp C, Loth J, Petrova I, Linnemannstöns K, Ulepic M, Fradkin L, Noordermeer J, Wodarz A.
<i>Drosophila</i> Ror is a nervous system-specific co-receptor for Wnt ligands.
Biol Open. 2018 Nov 2;7(11):bio033001. doi: 10.1242/bio.033001. PMID: 30341100; PMCID: PMC6262871.
6: Tiwari MD, Zeitler DM, Meister G, Wodarz A.
Molecular profiling of stem cell- like female germ line cells in <i>Drosophila</i> delineates networks important for stemness and differentiation.
Biol Open. 2019 Nov 12;8(11):bio046789. doi: 10.1242/bio.046789. PMID: 31649115; PMCID: PMC6899027.
7: Hohmann C, Pfister R, Mollenhauer M, Adler C, Kozlowski J, Wodarz A, Drebber U, Wippermann J, Michels G.
Inflammatory cell infiltration in left atrial appendageal tissues of patients with atrial fibrillation and sinus rhythm.
Sci Rep. 2020 Feb 3;10(1):1685. doi: 10.1038/s41598-020-58797-8. PMID: 32015492; PMCID: PMC6997354.
8: Linnemannstöns K, Witte L, Karuna M P, Kittel JC, Danieli A, Müller D, Nitsch L, Honemann-Capito M, Grawe F, Wodarz A, Gross JC.
Ykt6-dependent endosomal recycling is required for Wnt secretion in the <i>Drosophila</i> wing epithelium.
Development. 2020 Aug 14;147(15):dev185421. doi: 10.1242/dev.185421. PMID: 32611603; PMCID: PMC7438013.
9: Witte L, Linnemannstöns K, Schmidt K, Honemann-Capito M, Grawe F, Wodarz A, Gross JC.
The kinesin motor Klp98A mediates apical to basal Wg transport.
Development. 2020 Aug 14;147(15):dev186833. doi: 10.1242/dev.186833. PMID: 32665246; PMCID: PMC7438014.
10: Rust K, Wodarz A.
Transcriptional Control of Apical-Basal Polarity
Regulators. Int J Mol Sci. 2021 Nov 15;22(22):12340. doi: 10.3390/ijms222212340. PMID: 34830224; PMCID: PMC8624420.
11: Koehler S, Odenthal J, Ludwig V, Unnersjö Jess D, Höhne M, Jüngst C, Grawe F, Helmstädter M, Janku JL, Bergmann C, Hoyer PF, Hagmann HH, Walz G, Bloch W, Niessen C,
Schermer B, Wodarz A, Denholm B, Benzing T, Iden S, Brinkkoetter PT.
Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration
barrier.
Kidney Int. 2022 Apr;101(4):733-751. doi: 10.1016/j.kint.2021.11.030. Epub 2021 Dec 17. PMID: 34929254.
12: Pryymachuk G, El-Awaad E, Piekarek N, Drebber U, Maul AC, Hescheler J, Wodarz A, Pfitzer G, Neiss WF, Pietsch M, Schroeter MM.
Angiotensin II type 1 receptor localizes at the blood-bile barrier in humans and pigs.
Histochem Cell Biol. 2022 May;157(5):513-524. doi: 10.1007/s00418-022-02087-z. Epub 2022 Feb 28 PMID: 35229169; PMCID: PMC9114028.