Current SPP1782 projects

Project	PI	Collaborators	Institute
Cellular junctions as force anchors during epithelial shape transitions	Dr. Anne Classen	Ramya Balaji, Vanessa Weichselberger	CISA/HMH, Universität Freiburg
Mechanotransduction and signalling by the desmosome/keratin complex	Prof. Dr. Thomas M. Magin	Dr. Fanny Büchau, Dr. Katrin Rietscher	Institute of Biology, Leipzig
Molecular Force Measurements in Epithelial Junctions	Prof. Dr. Carsten Grashoff	Lukas Windgaße	Institut für Molekulare Zellbiologie, Münster
Mechano-sensing mechanisms in the desmosome from molecular simulations	Prof. Dr. Frauke Gräter	Dr. Csaba Daday, Dr. Fan Jin	Heidelberg Institute for Theoretical Studies, Heidelberg
Interplay between mechanical tension and cytoskeletal organization in cell separation at compartment boundaries in Drosophila	Prof. Dr. Christian Dahmann	Jing Wang	Institute of Genetics, Dresden
Molecular mechanisms patterning viscosity of the junctional network during Drosophila pupal wing morphogenesis	Prof. Dr. Suzanne Eaton (†)	Dr. Natalie Dye, Franz Gruber	Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
Coupling intercellular adhesion and cell polarity signaling at epidermal junctions	Prof. Dr. Sandra Iden	Martim Gomes, Michael Saynisch	CECAD, Köln
Coordinated dynamics of epithelial cells in the amnioserosa of Drosophila embryos	Prof. Dr. Jörg Großhans, Prof. Dr. Fred Wolf	Prachi Richa, Ankit Choudhury, Matthias Häring	Philipps-Universität, Marburg / MPI für Dynamik und Selbstorganisation, Göttingen
Characterization of plakophilins as desmosomal signalling hubs controlling intercellular adhesion and proliferation in the epidermis	Prof. Dr. Mechthild Hatzfeld	Dr. Rene Keil, Lisa Müller	Institute of Molecular Medicine, Halle
Tension Generation in Epithelial Cells – the Impact of Next Neighbors	Prof. Dr. Andreas Janshoff	Mark Skamrahl, Tanmaya Sethi	Institute of Physical Chemistry, Göttingen
Role of the tight junction-associated protein Amotl2a in regulating the Hippo pathway and the size of the posterior lateral line primordium in zebrafish	Prof. Dr. Virginie Lecaudey	Constanze Heinzen, Alicia Lardennois	Institut für Zellbiologie und Neurowissenschaft, Frankfurt
Mechanotransduction and cytoskeletal organization by cadherins in stratifying epithelia	Prof. Dr. Carien Niessen	Dr. Alexander Kyumurkov, Placido Pereira, Dr. Matthias Rübsam, Aishwarya Bhosale	CECAD, Köln
Desmosome-cytoskeleton dynamics	Prof. Dr. Rudolf Leube	Dr. Marcin Moch	MOCA, Aachen
Role of Dsg2-dependent adhesion and signalling in Crohn’s disease	Prof. Dr. Nicolas Schlegel, Prof. Dr. Jens Waschke	Hanna Ungewiss, Jessica Neubauer	Universitätsklinikum Würzburg / Institute of Anatomy and Cell Biology, München
Probing tensed cell-cell adhesions	Prof. Dr. Rudolf Merkel / Dr. Bernd Hoffmann	Dave Ahrens, Lena Ramms, Robin Püllen	Institute of Complex Systems, Jülich
New functions of Pals1 as a signaling hub at cell-cell contacts	Prof. Dr. Michael Krahn / Prof. Dr. Thomas Weide	Ann-Christin Groh, Simona Lüttgenau	Universitätsklinikum Münster
Piezo mechanosensitive receptor interplay with tight junction proteins for maintenance of epithelial cell number and integrity	Dr. Rocío López Posadas, Ph.D.	Phuong Ngo Anh	Universitätsklinikum Erlangen
Deciphering the role of mechanics for epithelia trans-differentiation	Dr. Alba Diz-Muñoz	Leanne Strauß	European Molecular Biology Laboratory (EMBL), Heidelberg
Reconstructed cell-cell interfaces with spatially defined mechanical and molecular components: biomimetic microenvironments to elucidate how extracellular mechanochemical signals are sensed and transmitted at the intercellular junctions	Prof. Dr. Aránzazu del Campo Bécares	Ana Díaz Álvarez, Dr. Mitchell Han	Leibniz-Institut für Neue Materialien (INM), Saarbrücken
LASP1 as a functional linker protein between cadherin and actin dynamics at epithelial adherens junctions	Prof. Dr. Hans-Joachim Schnittler	Nadine Klusmeier	Max Plank Institute For Molecular Biomedicine
Connecting intercellular cell junctions with Hippo/YAP pathway activity in hepatocytes and liver tumor cells	Dr. Kai Breuhahn	Lena Thiess	Universitätsklinikum Heidelberg
Functional analysis of the LIM domain protein Smallish in regulation of actomyosin contractility and junctional dynamics at the ZA	Prof. Dr. Andreas Wodarz	Patrizia Kroll, Dr. Irina Peek	Institut I für Anatomie, Köln

Members

Name	Position	Project	Institute
Balaji,Ramya	SPP funded collaborator	Cellular junctions as force anchors during epithelial shape transitions	CISA/HMH, Universität Freiburg
Classen,Dr. Anne	PI	Cellular junctions as force anchors during epithelial shape transitions	CISA/HMH, Universität Freiburg
Büchau,Dr. Fanny	SPP funded collaborator	Mechanotransduction and signalling by the desmosome/keratin complex	Institute of Biology, Leipzig
Magin,Prof. Dr. Thomas M.	PI	Mechanotransduction and signalling by the desmosome/keratin complex	Institute of Biology, Leipzig
Rietscher, Dr. Katrin	SPP associated collaborator	Mechanotransduction and signalling by the desmosome/keratin complex	Institute of Biology, Leipzig
Windgaße,Lukas	SPP funded collaborator	Molecular Force Measurements in Epithelial Junctions	Max Planck Institute of Biochemistry, Martinsried
Cost,Dr. Anna-Lena	SPP funded collaborator	Molecular Force Measurements in Epithelial Junctions	Max Planck Institute of Biochemistry, Martinsried
Grashoff,Prof. Dr. Carsten	PI	Molecular Force Measurements in Epithelial Junctions	Max Planck Institute of Biochemistry, Martinsried
Fan Jin	SPP funded collaborator	Mechano-sensing mechanisms in the desmosome from molecular simulations	Heidelberg Institute for Theoretical Studies, Heidelberg
Daday,Dr. Csaba	SPP funded collaborator	Mechano-sensing mechanisms in the desmosome from molecular simulations	Heidelberg Institute for Theoretical Studies, Heidelberg
Gräter,Prof. Dr. Frauke	PI	Mechano-sensing mechanisms in the desmosome from molecular simulations	Heidelberg Institute for Theoretical Studies, Heidelberg
Wang,Jing	SPP funded collaborator	Interplay between mechanical tension and cytoskeletal organization in cell separation at compartment boundaries in Drosophila	Institute of Genetics, Dresden
Dahmann,Prof. Dr. Christian	PI	Interplay between mechanical tension and cytoskeletal organization in cell separation at compartment boundaries in Drosophila	Institute of Genetics, Dresden
Dye,Dr. Natalie	SPP funded collaborator	Molecular mechanisms patterning viscosity of the junctional network during Drosophila pupal wing morphogenesis	Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
Eaton,Prof. Dr. Suzanne (†)	PI	Molecular mechanisms patterning viscosity of the junctional network during Drosophila pupal wing morphogenesis	Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
Gruber,Franz	SPP funded collaborator	Molecular mechanisms patterning viscosity of the junctional network during Drosophila pupal wing morphogenesis	Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
Gomes,Martim	SPP funded collaborator	Coupling intercellular adhesion and cell polarity signaling at epidermal junctions	CECAD, Köln
Iden,Prof. Dr. Sandra	PI	Coupling intercellular adhesion and cell polarity signaling at epidermal junctions	CECAD, Köln
Saynisch,Michael	SPP associated collaborator	Coupling intercellular adhesion and cell polarity signaling at epidermal junctions	CECAD, Köln
Großhans,Prof. Dr. Jörg	PI	Coordinated dynamics of epithelial cells in the amnioserosa of Drosophila embryos	Philipps-Universität, Marburg
Choudhury, Ankit	SPP funded collaborator	Coordinated dynamics of epithelial cells in the amnioserosa of Drosophila embryos	Philipps-Universität, Marburg
Richa,Prachi	SPP funded collaborator	Coordinated dynamics of epithelial cells in the amnioserosa of Drosophila embryos	Universität, Göttingen
Häring, Matthias	SPP funded collaborator	Coordinated dynamics of epithelial cells in the amnioserosa of Drosophila embryos	Max-Planck-Institut für Dynamik und Selbstorganisation, Göttingen
Wolf,Prof. Dr. Fred	PI	Coordinated dynamics of epithelial cells in the amnioserosa of Drosophila embryos	Max-Planck-Institut für Dynamik und Selbstorganisation, Göttingen
Hatzfeld,Prof. Dr. Mechthild	PI	Characterization of plakophilins as desmosomal signalling hubs controlling intercellular adhesion and proliferation in the epidermis	Institute of Molecular Medicine, Halle
Keil,Dr. Rene	SPP associated collaborator	Characterization of plakophilins as desmosomal signalling hubs controlling intercellular adhesion and proliferation in the epidermis	Institute of Molecular Medicine, Halle
Müller,Lisa	SPP funded collaborator	Characterization of plakophilins as desmosomal signalling hubs controlling intercellular adhesion and proliferation in the epidermis	Institute of Molecular Medicine, Halle
Janshoff,Prof. Dr. Andreas	PI	Tension Generation in Epithelial Cells – the Impact of Next Neighbors	Institute of Physical Chemistry, Göttingen
Karsch,Susanne	SPP funded collaborator	Tension Generation in Epithelial Cells – the Impact of Next Neighbors	Institute of Physical Chemistry, Göttingen
Sethi,Tanmaya	SPP funded collaborator	Tension Generation in Epithelial Cells – the Impact of Next Neighbors	Institute of Physical Chemistry, Göttingen
Skamrahl,Mark	SPP funded collaborator	Tension Generation in Epithelial Cells – the Impact of Next Neighbors	Institute of Physical Chemistry, Göttingen
Kleinhans,David	SPP funded collaborator	Role of the tight junction-associated protein Amotl2a in regulating the Hippo pathway and the size of the posterior lateral line primordium in zebrafish	Institut für Zellbiologie und Neurowissenschaft, Frankfurt
Lecaudey,Prof. Dr. Virginie	PI	Role of the tight junction-associated protein Amotl2a in regulating the Hippo pathway and the size of the posterior lateral line primordium in zebrafish	Institut für Zellbiologie und Neurowissenschaft, Frankfurt
Molenda,Christine	SPP funded collaborator	Role of the tight junction-associated protein Amotl2a in regulating the Hippo pathway and the size of the posterior lateral line primordium in zebrafish	Institut für Zellbiologie und Neurowissenschaft, Frankfurt
Kyumurkov,Dr. Alexander	SPP associated collaborator	Mechanotransduction and cytoskeletal organization by cadherins in stratifying epithelia	CECAD, Köln
Niessen,Prof. Dr. Carien	PI	Mechanotransduction and cytoskeletal organization by cadherins in stratifying epithelia	CECAD, Köln
Pereira,Placido	SPP funded collaborator	Mechanotransduction and cytoskeletal organization by cadherins in stratifying epithelia	CECAD, Köln
Rübsam,Dr. Matthias	SPP associated collaborator	Mechanotransduction and cytoskeletal organization by cadherins in stratifying epithelia	CECAD, Köln
Leube,Prof. Dr. Rudolf	PI	Desmosome-cytoskeleton dynamics	MOCA, Aachen
Moch,Dr. Marcin	SPP funded collaborator	Desmosome-cytoskeleton dynamics	MOCA, Aachen
Schlegel,Prof. Dr. Nicolas	PI	Role of Dsg2-dependent adhesion and signalling in Crohn’s disease	Klinik und Poliklinik für Allgemein-, Viszeral-, Gefähß-, und Kinderchirurgie, Würzburg
Ungewiss,Hanna	SPP funded collaborator	Role of Dsg2-dependent adhesion and signalling in Crohn’s disease	Institute of Anatomy and Cell Biology, München
Neubauer,Jessica	SPP funded collaborator	Role of Dsg2-dependent adhesion and signalling in Crohn’s disease	Institute of Anatomy and Cell Biology, München
Waschke,Prof. Dr. Jens	PI	Role of Dsg2-dependent adhesion and signalling in Crohn’s disease	Institute of Anatomy and Cell Biology, München
Ahrens,Dave	SPP funded collaborator	Probing tensed cell-cell adhesions	Institute of Complex Systems, Jülich
Merkel,Prof. Dr. Rudolf	PI	Probing tensed cell-cell adhesions	Institute of Complex Systems, Jülich
Hoffmann,Dr. Bernd	PI	Probing tensed cell-cell adhesions	Institute of Complex Systems, Jülich
Pfüllen, Robin	SPP funded collaborator	Probing tensed cell-cell adhesions	Institute of Complex Systems, Jülich
Ramms,Lena	SPP funded collaborator	Probing tensed cell-cell adhesions	Institute of Complex Systems, Jülich
Krahn,Prof. Dr. Michael	PI	New functions of Pals1 as a signaling hub at cell-cell contacts	Universitätsklinikum Münster
Weide, Prof. Dr. Thomas	PI	New functions of Pals1 as a signaling hub at cell-cell contacts	Universitätsklinikum Münster
Groh,Ann-Christin	SPP funded collaborator	New functions of Pals1 as a signaling hub at cell-cell contacts	Universitätsklinikum Münster
Lüttgenau,Simona	SPP funded collaborator	New functions of Pals1 as a signaling hub at cell-cell contacts	Universitätsklinikum Münster
Ngo Anh, Phuong	SPP funded collaborator	Piezo mechanosensitive receptor interplay with tight junction proteins for maintenance of epithelial cell number and integrity	Universitätsklinikum Erlangen
López Posadas,Ph.D. Dr. Rocío	PI	Piezo mechanosensitive receptor interplay with tight junction proteins for maintenance of epithelial cell number and integrity	Universitätsklinikum Erlangen
Thiess, Lena	SPP funded collaborator	Connecting intercellular cell junctions with Hippo/YAP pathway activity in hepatocytes and liver tumor cells	Universitätsklinikum Heidelberg
Breuhahn,Dr. Kai	PI	Connecting intercellular cell junctions with Hippo/YAP pathway activity in hepatocytes and liver tumor cells	Universitätsklinikum Heidelberg
Klusmeier,Nadine	SPP funded collaborator	LASP1 as a functional linker protein between cadherin and actin dynamics at epithelial adherens junctions	Universitätsklinikum Münster
Schnittler,Prof. Dr. Hans-Joachim	PI	LASP1 as a functional linker protein between cadherin and actin dynamics at epithelial adherens junctions	Universitätsklinikum Münster
Strauß, Leanne	SPP funded collaborator	Deciphering the role of mechanics for epithelia trans-differentiation	European Molecular Biology Laboratory (EMBL), Heidelberg
Diz-Muñoz,Dr. Alba	PI	Deciphering the role of mechanics for epithelia trans-differentiation	European Molecular Biology Laboratory (EMBL), Heidelberg
Han,Dr. Mitchell	SPP funded collaborator	Reconstructed cell-cell interfaces with spatially defined mechanical and molecular components: biomimetic microenvironments to elucidate how extracellular mechanochemical signals are sensed and transmitted at the intercellular junctions	Leibniz-Institut für Neue Materialien (INM), Saarbrücken
Diaz,Ana	SPP funded collaborator	Reconstructed cell-cell interfaces with spatially defined mechanical and molecular components: biomimetic microenvironments to elucidate how extracellular mechanochemical signals are sensed and transmitted at the intercellular junctions	Leibniz-Institut für Neue Materialien (INM), Saarbrücken
del Campo Bécares,Prof. Dr. Aránzazu	PI	Reconstructed cell-cell interfaces with spatially defined mechanical and molecular components: biomimetic microenvironments to elucidate how extracellular mechanochemical signals are sensed and transmitted at the intercellular junctions	Leibniz-Institut für Neue Materialien (INM), Saarbrücken
Kroll,Patrizia	SPP funded collaborator	Functional analysis of the LIM domain protein Smallish in regulation of actomyosin contractility and junctional dynamics at the ZA	Institut I für Anatomie, Köln
Peek,Irina	SPP funded collaborator	Functional analysis of the LIM domain protein Smallish in regulation of actomyosin contractility and junctional dynamics at the ZA	Institut I für Anatomie, Köln
Wodarz,Prof. Dr. Andreas	PI	Functional analysis of the LIM domain protein Smallish in regulation of actomyosin contractility and junctional dynamics at the ZA	Institut I für Anatomie, Köln

Completed SPP1782 projects [first funding period]

Project	PI	Collaborators	Institute
Mechanobiological Analysis of Microtubule-Based Forces at Epithelial Adherens Junctions During Tissue Morphogenesis	Dr. Maja Matis	Amrita Singh	Institute of Cell Biology, Münster
Consequences of desmosomal alterations in the intestinal epithelia	PD Dr. Pavel Strnad	Prof. Dr. Peter Boor, Dr. Sonja Djudjaj, Annika Gros	Department of Internal Medicine III, Aachen Institute of Pathology, Aachen
Role of JAM family adhesion molecules in epithelial cell extrusion	Prof. Dr. Klaus Ebnet	Christian Hartmann	Institute of Medical Biochemistry, Münster
SPP 1782 Grill/Knust	Prof. Dr. Stephan Grill / Prof. Dr. Elisabeth Knust	Dr. David Flores-Benitez	Biotec, Dresden, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
SPP 1782 Grosse	Prof. Dr. Robert Grosse	Dr. Katharina Grikscheit, Hanna Grobe	Institute of Pharmacology, Universität Marburg
SPP 1782 Spindler	Associate Prof. Dr. med. Volker Spindler		Institute of Anatomy and Cell Biology, München